Skip Navigation LinksHome > March 2014 - Volume 24 - Issue 3 > Serous Ovarian Cancer Signaling Pathways
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0000000000000079
Review Articles

Serous Ovarian Cancer Signaling Pathways

Kotsopoulos, Ioannis C. MD*; Papanikolaou, Alexios MD, PhD; Lambropoulos, Alexandros F. PhD; Papazisis, Konstantinos T. MD, PhD; Tsolakidis, Dimitrios MD, PhD; Touplikioti, Panagiota PhD§; Tarlatzis, Basil C. MD, PhD

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Abstract: Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.


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