Skip Navigation LinksHome > March 2014 - Volume 24 - Issue 3 > Prognostic Factors in Women With Synchronous Endometrial and...
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0000000000000073
Uterine Cancer

Prognostic Factors in Women With Synchronous Endometrial and Ovarian Cancers

Song, Taejong MD*; Seong, Seok Ju MD, PhD*; Bae, Duk-Soo MD, PhD; Kim, Jong-Hyeok MD, PhD; Suh, Dong Hoon MD, PhD§; Lee, Keun-Ho MD, PhD; Park, Sang-Yoon MD, PhD; Lee, Taek Sang MD, PhD#

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Abstract

Objective

The purpose of this study was to determine the prognostic factors in women with synchronous endometrial and ovarian cancers.

Methods

Medical records of 3240 patients with endometrial cancer who had undergone primary surgery were collected from 7 institutions and were retrospectively reviewed. The progression-free survival (PFS) and overall survival (OS) curves and rates were calculated using the Kaplan-Meier method. Multivariate analysis to determine independent prognostic factors was performed using the Cox regression model.

Results

The incidence of synchronous endometrial/ovarian cancer was 3.8% (123/3240 women). During the median follow-up period of 66 months, 33.3% and 26.1% of women developed recurrences and reported cancer-related deaths. The 5-year PFS and 5-year OS for all 123 women were 66.9% and 80.0%, respectively. In multivariate analysis, pretreatment CA-125 and tumor stage of the ovary showed prognostic significance about PFS (P = 0.043 and P = 0.027) and OS (P = 0.047 and P = 0.031), respectively.

Conclusions

Pretreatment CA-125 and tumor stage of the ovary were independent prognostic factors for recurrence and survival.

Copyright © 2014 by IGCS and ESGO

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