Skip Navigation LinksHome > February 2014 - Volume 24 - Issue 2 > Prognosis of Adenosquamous Carcinoma Compared With Adenocarc...
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0000000000000063
Cervical Cancer

Prognosis of Adenosquamous Carcinoma Compared With Adenocarcinoma in Uterine Cervical Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Lee, Jung-Yun MD*; Lee, Chulmin MD, PhD; Hahn, SeoKyung PhD; Kim, Min A. MD, PhD§; Kim, Hee Seung MD*; Chung, Hyun Hoon MD, PhD*; Kim, Jae-Weon MD, PhD*; Park, Noh Hyun MD, PhD*; Song, Yong-Sang MD, PhD*

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Abstract

Objective

The aim of this study was to compare the survival outcomes of adenosquamous carcinoma (ASC) and adenocarcinoma (AC) of the cervix.

Methods

We searched PubMed and Embase for observational studies that compared the outcomes of 2 histologic subtypes. Hazards ratios (HRs) with 95% confidence intervals (CIs) were calculated with a fixed effects model.

Results

A total of 17 studies were included in the analyses. Patients with ASC were associated significantly with poorer overall survival (death HR, 1.27; 95% CI, 1.12–1.43; I2 = 0%) and recurrence-free survival (recurrence HR, 1.43; 95% CI, 1.05–1.95; I2 = 19.4%) than those with AC. For clinical stages I and II in particular, ASC predicted significantly poorer outcomes compared with AC (death HR, 1.41; 95% CI, 1.17–1.70; I2 = 0%).

Conclusions

This meta-analysis suggests that ASC may have poorer outcomes compared with AC of the cervix.

Copyright © 2014 by IGCS and ESGO

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