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Cervical Conization and Sentinel Lymph Node Mapping in the Treatment of Stage I Cervical Cancer: Is Less Enough?

Andikyan, Vaagn MD*; Khoury-Collado, Fady MD*; Denesopolis, John BS*; Park, Kay J. MD; Hussein, Yaser R. MD; Brown, Carol L. MD*‡; Sonoda, Yukio MD*‡; Chi, Dennis S. MD*‡; Barakat, Richard R. MD*‡; Abu-Rustum, Nadeem R. MD*‡

International Journal of Gynecological Cancer: January 2014 - Volume 24 - Issue 1 - p 113–117
doi: 10.1097/IGC.0000000000000034
Cervical Cancer

Objectives This study aimed to determine the feasibility of cervical conization and sentinel lymph node (SLN) mapping as a fertility-sparing strategy to treat stage I cervical cancer and to estimate the tumor margin status needed to achieve no residual carcinoma in the cervix.

Methods We identified all patients who desired fertility preservation and underwent SLN mapping with cervical conization for stage I cervical cancer from September 2005 to August 2012. Relevant demographic, clinical, and pathologic information was collected.

Results Ten patients were identified. Median age was 28 years (range, 18–36 years). None of the patients had a grossly visible tumor. The initial diagnosis of invasive carcinoma was made either on a loop electrosurgical excision procedure or cone biopsy. All patients underwent preoperative radiologic evaluation (magnetic resonance imaging and positron emission tomography–computed tomography). None of the patients had evidence of gross tumor or suspicion of lymph node metastasis on imaging. Stage distribution included 7 (70%) patients with stage IA1 cervical cancer with lymphovascular invasion and 3 (30%) patients with microscopic IB1. Histologic diagnosis included 8 (80%) patients with squamous cell carcinoma, 1 (10%) patient with adenocarcinoma, and 1 (10%) patient with clear cell carcinoma. Nine patients underwent repeat cervical conization with SLN mapping, and 1 patient underwent postconization cervical biopsies and SLN mapping. None of the patients had residual tumor identified on the final specimen. The median distance from the invasive carcinoma to the endocervical margin was 2.25 mm, and the distance from the invasive carcinoma to the ectocervical margin was 1.9 mm. All collected lymph nodes were negative for metastasis. After a median follow-up of 17 months (range, 1–83 months), none of the patients’ conditions were diagnosed with recurrent disease and 3 (30%) patients achieved pregnancy.

Conclusions Cervical conization and SLN mapping seems to be an acceptable treatment strategy for selected patients with small-volume stage I cervical cancer. Tumor clearance of 2 mm and above seems to correlate well with no residual on repeat conization. A larger sample size and longer follow-up is needed to establish the long-term outcomes of this procedure.

Departments of *Surgery, Gynecology Service, and †Pathology, Memorial Sloan-Kettering Cancer Center; and ‡Department of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY.

Address correspondence and reprint requests to Nadeem R. Abu-Rustum, MD, Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10065. E-mail: Abu-rusn@mskcc.org.

The authors declare no conflicts of interest.

Received March 18, 2013

Accepted October 17, 2013

© 2014 by the International Gynecologic Cancer Society and the European Society of Gynaecological Oncology.