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Cluster of Differentiation 24 Expression Is an Independent Prognostic Factor of Adverse Outcome in Cervical Carcinoma

Huang, Lee-Wen MD*†‡; Lee, Chin-Cheng MD, PhD‡§∥

International Journal of Gynecological Cancer: February 2013 - Volume 23 - Issue 2 - p 325–330
doi: 10.1097/IGC.0b013e318280810a
Cervical Cancer

Objective Cluster of differentiation (CD) 24 is a cell adhesion molecule that has been implicated in tumor invasion and metastasis of various solid tumors. The aim of this study was to explore the expression patterns of CD24 as a predictive marker for long-term survival in cervical carcinomas.

Methods A total of 144 patients diagnosed with International Federation of Gynecology and Obstetrics stage I to IV cervical carcinoma were studied, and 95 patients underwent surgical intervention. The expression of CD24 protein was studied by immunohistochemistry using tissue microarrays.

Results Overexpression of CD24 was observed in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24 overexpression had poorer survival compared with that of patients with CD24 underexpression (5-year survival rate, 52.0% vs 72.3%; log rank P = 0.014). Importantly, in multivariate analysis, CD24 overexpression proved to be a significant independent predictor of short-term survival (relative risk, 1.814; P = 0.043).

Conclusions The present study suggests that CD24 overexpression is a predictor of decreased long-term survival in patients with cervical carcinoma. Therefore, immunohistochemical evaluation of CD24 expression is a potential prognostic biomarker for cervical carcinomas.

*Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; †School of Medicine, Fu-Jen Catholic University, New Taipei City; ‡School of Medicine, Taipei Medical University; and §Department of Pathology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; and ∥Department of Nursing, Yuanpei University, Hsinchu, Taiwan.

Address correspondence and reprint requests to Lee-Wen Huang, MD, Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei City 111, Taiwan. E-mail: m002057@ms.skh.org.tw.

This study was supported by a research grant (SKH-8302-99-DR-29, SKH-8302-100-DR-09) from the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

The authors declare no conflicts of interest.

Received October 25, 2012

Accepted November 29, 2012

Copyright © 2013 by IGCS and ESGO