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International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0b013e318280810a
Cervical Cancer

Cluster of Differentiation 24 Expression Is an Independent Prognostic Factor of Adverse Outcome in Cervical Carcinoma

Huang, Lee-Wen MD*†‡; Lee, Chin-Cheng MD, PhD‡§∥

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Abstract

Objective: Cluster of differentiation (CD) 24 is a cell adhesion molecule that has been implicated in tumor invasion and metastasis of various solid tumors. The aim of this study was to explore the expression patterns of CD24 as a predictive marker for long-term survival in cervical carcinomas.

Methods: A total of 144 patients diagnosed with International Federation of Gynecology and Obstetrics stage I to IV cervical carcinoma were studied, and 95 patients underwent surgical intervention. The expression of CD24 protein was studied by immunohistochemistry using tissue microarrays.

Results: Overexpression of CD24 was observed in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24 overexpression had poorer survival compared with that of patients with CD24 underexpression (5-year survival rate, 52.0% vs 72.3%; log rank P = 0.014). Importantly, in multivariate analysis, CD24 overexpression proved to be a significant independent predictor of short-term survival (relative risk, 1.814; P = 0.043).

Conclusions: The present study suggests that CD24 overexpression is a predictor of decreased long-term survival in patients with cervical carcinoma. Therefore, immunohistochemical evaluation of CD24 expression is a potential prognostic biomarker for cervical carcinomas.

Copyright © 2013 by IGCS and ESGO

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