Objective: Cluster of differentiation (CD) 24 is a cell adhesion molecule that has been implicated in tumor invasion and metastasis of various solid tumors. The aim of this study was to explore the expression patterns of CD24 as a predictive marker for long-term survival in cervical carcinomas.
Methods: A total of 144 patients diagnosed with International Federation of Gynecology and Obstetrics stage I to IV cervical carcinoma were studied, and 95 patients underwent surgical intervention. The expression of CD24 protein was studied by immunohistochemistry using tissue microarrays.
Results: Overexpression of CD24 was observed in 50 (34.7%) of 144 invasive carcinomas. Patients with CD24 overexpression had poorer survival compared with that of patients with CD24 underexpression (5-year survival rate, 52.0% vs 72.3%; log rank P = 0.014). Importantly, in multivariate analysis, CD24 overexpression proved to be a significant independent predictor of short-term survival (relative risk, 1.814; P = 0.043).
Conclusions: The present study suggests that CD24 overexpression is a predictor of decreased long-term survival in patients with cervical carcinoma. Therefore, immunohistochemical evaluation of CD24 expression is a potential prognostic biomarker for cervical carcinomas.
*Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; †School of Medicine, Fu-Jen Catholic University, New Taipei City; ‡School of Medicine, Taipei Medical University; and §Department of Pathology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei; and ∥Department of Nursing, Yuanpei University, Hsinchu, Taiwan.
Address correspondence and reprint requests to Lee-Wen Huang, MD, Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Shih Lin District, Taipei City 111, Taiwan. E-mail: firstname.lastname@example.org.
This study was supported by a research grant (SKH-8302-99-DR-29, SKH-8302-100-DR-09) from the Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
The authors declare no conflicts of interest.
Received October 25, 2012
Accepted November 29, 2012