Skip Navigation LinksHome > February 2013 - Volume 23 - Issue 2 > Clinical and Prognostic Significance of Coagulation Assays i...
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0b013e31827b8796
Ovarian Cancer

Clinical and Prognostic Significance of Coagulation Assays in Advanced Epithelial Ovarian Cancer

Tas, Faruk MD; Kilic, Leyla MD; Bilgin, Elif PhD; Keskin, Serkan MD; Sen, Fatma MD; Ciftci, Rumeysa MD; Yildiz, Ibrahim MD; Yasasever, Vildan PhD

Collapse Box

Abstract

Objective: Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological tumors and usually diagnosed at advanced stage. We aimed to identify the clinical and prognostic relevance of coagulation tests and their correlation with serum CA-125 levels in advanced EOC.

Materials and Methods: A total of 33 advanced-stage (stages III and IV) EOC patients were enrolled in the study. Of these patients, 17 had received neoadjuvant chemotherapy and 16 patients received chemotherapy after optimal debulking surgery. Several clinicopathologic factors, coagulation assays, routine biochemistry tests, and serum CA-125 levels were evaluated before treatment and compared with healthy subjects.

Results: All coagulation tests including prothrombin time (PT), activated partial thromboplastin time, international normalized ratio, fibrinogen, D-dimer, and platelet revealed statistically significant difference between patients and control subjects (P ≤ 0.001). Elevated CA-125 levels were correlated with higher D-dimer values (P = 0.03). Prolonged PT was associated with poorer both overall (P = 0.03) and progression-free survival rates (P = 0.04).

Conclusions: Correlation of CA-125 with D-dimer is supposed to reflect hyperactivation of fibrinolytic pathway in the presence of a higher tumor load. Alterations in coagulation pathway reflected by prolonged PT support prognostic effects on survival of advanced-stage EOC patients.

Copyright © 2013 by IGCS and ESGO

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

Twitter
twitter.com/IJGConline

For additional oncology content, visit LWW Oncology Journals on Facebook.