The Role of Intraoperative Radiation Therapy in the Management of Recurrent and Locally Advanced Gynecologic Cancers

Foley, Olivia W. BS; Rauh-Hain, J. Alejandro MD; del Carmen, Marcela G. MD, MPH

International Journal of Gynecological Cancer: January 2013 - Volume 23 - Issue 1 - p 9–15
doi: 10.1097/IGC.0b013e318275232f
Reviews

Abstract: For patients with locally advanced primary or recurrent gynecologic cancers, prognosis is poor. Doses of external beam radiation therapy required to treat either gross or microscopic disease in patients previously irradiated or treated surgically exceed doses that are tolerated by normal anatomic structures. Intraoperative radiation therapy allows maximal tumor control achievable with radiation while minimizing radiation exposure of dose-limiting surrounding structures. Intraoperative radiation therapy is a unique treatment modality, allowing direct visualization of the target volume during a planned surgical procedure. Intraoperative radiation therapy has the potential to improve both long-term local control and overall survival especially in patients with para-aortic and/or pelvic sidewall recurrences.

Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Address correspondence and reprint requests to Marcela G. del Carmen, MD, MPH, Division of Gynecologic Oncology, Vincent Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit St, Yawkey 9 E, Boston, MA 02114. E-mail: mdelcarmen@partners.org.

This work was not supported by any grant or other type of funding.

The authors declare no conflict of interest.

Received August 6, 2012

Accepted Sept 19, 2012

Copyright © 2013 by IGCS and ESGO