Skip Navigation LinksHome > January 2013 - Volume 23 - Issue 1 > Interleukin 10 Polymorphisms and Cervical Cancer Risk: A Met...
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0b013e318274b1a2
Cervical Cancer

Interleukin 10 Polymorphisms and Cervical Cancer Risk: A Meta-Analysis

Ni, Jing MD*; Ye, Yang PhD; Teng, Fang MD; Wu, Qiang PhD*

Collapse Box

Abstract

Background: A debate exists about whether interleukin 10 (IL-10) polymorphisms (IL-10−1082G/A and IL-10−592C/A) confer additional risk for cervical cancer. To derive a more precise estimation of the relationship between IL-10 polymorphisms and cervical cancer risk, we conducted a meta-analysis of all available studies relating the −1082G/A and −592C/A polymorphisms of the IL-10 gene to the risk of developing cervical cancer.

Methods: Eight studies were eligible for IL-10 −1082G/A (1498 cases and 1608 controls), and 5 studies were eligible for IL-10 −592C/A (2396 cases and 1388 controls). Pooled odds ratios (ORs) were appropriately derived from fixed-effects or random-effects models. Subgroup analyses were performed by ethnicity and Hardy-Weinberg equilibrium in the controls.

Results: In the overall analysis, no significant association between the IL-10−1082G/A polymorphism and the risk of cervical cancer was observed. In the subgroup analysis by ethnicity, IL-10 −1082A allele was associated with decreased cervical cancer susceptibility among whites (A vs G: OR, 0.39; 95% confidence interval [CI], 0.32–0.47). Studies with controls deviated from Hardy-Weinberg equilibrium showed an evident association in dominant model (GA/AA vs GG: OR, 1.73 [95% CI, 1.04–2.89]). On the other hand, with respect to −592C/A polymorphism, significantly elevated cervical cancer risk was found in the overall analysis (A vs C: OR, 1.16 [95% CI, 1.04–1.31]; AA vs CC: OR, 1.36 [95% CI, 1.00–1.84]; CA/AA vs CC: OR, 1.18 [95% CI, 1.01–1.39]; AA vs CC/CA: OR, 1.25 [95% CI, 1.01–1.55]). Stratified analysis indicated that significantly increased risks were also found among Asians in the allelic model (A vs C: OR, 1.23 [95% CI, 1.01–1.49]).

Conclusions: Interleukin 10−1082 G/A polymorphism showed no effect on cervical cancer risk in the overall analysis. The genetic polymorphism in IL-10−592C/A is a risk factor for developing cervical cancer, especially for Asians.

Copyright © 2013 by IGCS and ESGO

Login

Article Tools

Share

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us

Twitter
twitter.com/IJGConline

For additional oncology content, visit LWW Oncology Journals on Facebook.