Skip Navigation LinksHome > July 2012 - Volume 22 - Issue 6 > Management and Prognosis of Clear Cell Borderline Ovarian Tu...
International Journal of Gynecological Cancer:
doi: 10.1097/IGC.0b013e3182534acf
Ovarian Cancer

Management and Prognosis of Clear Cell Borderline Ovarian Tumor

Uzan, Catherine MD, PhD*†; Dufeu-Lefebvre, Marion MD*; Fauvet, Raffaele MD, PhD‡§; Gouy, Sebastien MD*; Duvillard, Pierre MD; Darai, Emile MD, PhD¶#**; Morice, Philippe MD, PhD*†††

Collapse Box


Background: The clear cell borderline ovarian tumor (CCBOT) of the ovary is a rare tumor accounting for less than 1% of BOT. Fewer than 25 cases have been reported in the literature (including details on clinical management and outcomes). The aim of this study was to determine the prognosis of a series of CCBOTs collected in 2 reference centers.

Patients and Methods: This was a retrospective review of patients with CCBOT treated or referred to our institutions. A centralized histological review by a reference pathologist and data on the clinical characteristics, management, and outcomes of patients were required for inclusion.

Results: Twelve patients were identified between 2000 and 2010. The median age of patients was 68 years (range, 36–83 years). Two had been treated conservatively and 9 radically (data unknown in 1). The tumor was unilateral in 11 cases. All patients had stage I disease. All cases were CCBOT with an adenofibromatous pattern. Stromal microinvasion or intraepithelial carcinoma was histologically associated in 2 and 3 cases, respectively. Four of the 12 patients had synchronous endometrial disorders (but no endometrioid carcinoma). No cases were histologically associated with endometriosis. Four patients were lost to follow-up. Among 8 other patients, after a median period of 28 months (range, 2–129 months), no recurrence had occurred (1 patient had died of another disease).

Conclusion: Clear cell borderline ovarian tumor carries a good prognosis. All tumors are stage I; therefore, surgical staging is not necessary in most of the cases. Conservative treatment could be proposed to young patients, but uterine curettage would then be required in cases of uterine preservation.

Copyright © 2012 by IGCS and ESGO


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.

Connect With Us


For additional oncology content, visit LWW Oncology Journals on Facebook.