Skip Navigation LinksHome > December 2010 - Volume 20 - Issue 9 > Prognostic and Predictive Values of E-Cadherin for Patients...
International Journal of Gynecological Cancer:
doi: 10.1111/IGC.0b013e3181e68a4d
Ovarian Cancer

Prognostic and Predictive Values of E-Cadherin for Patients of Ovarian Clear Cell Adenocarcinoma

Ho, Chih-Ming MD, PhD*†‡; Cheng, Wen-Fang MD, PhD§; Lin, Ming-Chieh MD∥; Chen, Tze-Chien MD¶; Huang, Shih-Hung MD#; Liu, Fu-Shing MD**; Chien, Chan-Chao Chang MD††; Yu, Mu-Hsien MD, PhD‡‡; Wang, Tao-Yeuan MD§§; Hsieh, Chang-Yao MD, MSPH§

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Objectives: The purpose of the study was to analyze negative versus positive immunoexpression of epithelial cadherin (E-cadherin) and p53 in patients with primary advanced ovarian clear cell adenocarcinoma (OCCA) and its significance in relation to clinical features, progression-free survival and overall survival (OS).

Methods and Materials: Protein expression of E-cadherin and p53 was immunohistochemically evaluated in 61 OCCA patients with stages IIC to IV. The clinical factors studied included stage, age, CA-125, residual tumors, and chemotherapy regimens.

Results: Positive p53 immunoexpression was 44.8% (26/58) of OCCAs; in contrast, E-cadherin immunoexpression was observed in 75.9% (44/58) of OCCAs. The expected 5-year OS rate of OCCA treated with paclitaxel-based chemotherapy was significantly better than non-paclitaxel-based chemotherapy (40% vs 0%, P = 0.001). The expected 5-year OS rate of OCCA patients with positive E-cadherin immunoexpression (>10%) was also significantly better than patients with negative E-cadherin immunoexpression (≤10%) (35% vs 0%, P = 0.02). The expected 5-year OS rate of those receiving paclitaxel-platinum chemotherapy was not significantly different from platinum-based chemotherapy for those with negative E-cadherin immunoexpression (P = 0.11). The expected 5-year OS rate of those receiving paclitaxel-based chemotherapy was better than non-paclitaxel-based chemotherapy for those with positive E-cadherin immunoexpression (43% vs 0%, P = 0.01). Paclitaxel-based chemotherapy and positive E-cadherin immunoexpression were 2 independent prognostic factors in OS of patients with OCCA (P = 0.01 and 0.04, respectively).

Conclusions: E-cadherin is a useful prognostic marker for OCCA patients, and paclitaxel-based chemotherapy can improve survival among patients with positive E-cadherin immunoreactivity.

Copyright © 2010 by IGCS and ESGO


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