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International Journal of Gynecological Cancer:
doi: 10.1111/IGC.0b013e3181fcd089
Ovarian Cancer

Less Impact of Adjuvant Chemotherapy for Stage I Clear Cell Carcinoma of the Ovary: A Retrospective Japan Clear Cell Carcinoma Study

Takano, Masashi MD, PhD*; Sugiyama, Toru MD, PhD†; Yaegashi, Nobuo MD, PhD‡; Sagae, Satoru MD, PhD§; Kuzuya, Kazuo MD, PhD∥; Udagawa, Yasuhiro MD, PhD¶; Tsuda, Hiroshi MD, PhD**; Suzuki, Mitsuaki MD, PhD††; Kigawa, Junzo MD, PhD‡‡; Goto, Tomoko MD, PhD*; Tsuda, Hitoshi MD, PhD§§; Moriya, Takuya MD, PhD∥∥; Kikuchi, Yoshihiro MD, PhD¶¶

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Abstract

Introduction: Ovarian clear cell carcinoma (CCC) is regarded as grade 3 tumor, and the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines recommend adjuvant chemotherapy for the tumor even at stage IA. However, CCC often showed chemo-resistant phenotype, and the effect of adjuvant chemotherapy still remained uncertain.

Methods: Clear cell carcinoma cases treated at collaborating institutions during the period 1992-2005 were retrospectively identified. After a central pathological review, survival analysis was estimated by the Kaplan-Meier method, and prognostic factors were evaluated using a Cox regression model.

Results: Among 219 patients with stage I CCC, 195 patients received adjuvant chemotherapy (C+) and 24 patients (C−) did not. The C+ group had 77 pT1a and 118 pT1c cases, and the C− group included 18 pT1a and 6 pT1c tumors (P < 0.001). The median age was 52 years in the C+ group and 57 years in C− group (P = 0.04). During the median follow-up period of 48 months (range, 7-160 years), relapse was observed in one patient (4%) in the C− group and in 35 patients (18%) in the C+ group. There were no statistical differences of progression-free survival and overall survival between the C+ and the C− groups. Multivariate analysis revealed that peritoneal cytology status (P = 0.02) and pT status (P = 0.04) were independent prognostic factors for progression-free survival; however, adjuvant chemotherapy was not a prognostic factor (P = 0.80).

Conclusions: Although the present study was a limited retrospective investigation, it suggested that adjuvant chemotherapy had little impact on the survival of stage I CCC patients. Further strategy, such as a molecular targeting agent, is needed to improve survival of CCC, especially in cases with positive peritoneal washing.

Copyright © 2010 by IGCS and ESGO

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