Home Current Issue Previous Issues Published Ahead-of-Print For Authors Journal Info
Skip Navigation LinksHome > June 2013 - Volume 19 - Issue 7 > Practical Strategies for Enhancing Adherence to Treatment Re...
Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0b013e3182813482
Clinical Review Article

Practical Strategies for Enhancing Adherence to Treatment Regimen in Inflammatory Bowel Disease

Greenley, Rachel N. PhD*; Kunz, Jennifer H. PhD*; Walter, Jennifer BA*; Hommel, Kevin A. PhD

Free Access
Article Outline
Collapse Box

Author Information

*Department of Psychology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois; and

Center for the Promotion of Treatment Adherence and Self-Management, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Reprints: Rachel Neff Greenley, PhD, Department of Psychology, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 (e-mail: rachel.greenley@rosalindfranklin.edu).

Supported by the Crohn's and Colitis Foundation of America Senior Research Award 2838 (RG) and K23 DK079037; R03 DK087822; R01 HD067174 (KH).

The authors have no conflicts of interest to disclose.

Received September 06, 2012

Accepted September 24, 2012

Collapse Box

Abstract

Promoting adherence to treatment among pediatric and adult patients with inflammatory bowel disease (IBD) is a critical yet challenging task for health care providers. Several existing interventions to enhance adherence among individuals with IBD offer useful information about practical strategies to enhance adherence. The current review article has 3 goals. First, the review provides a context for understanding treatment regimen adherence in IBD by reviewing key definitional, measurement, and conceptual challenges in this area. Next, published studies focused on interventions to enhance adherence in IBD are briefly summarized, followed by a synthesis of practical adherence promotion strategies for use in IBD by health care providers. Strategies are distinguished by the level of evidence supporting their utility as well as by age group. Finally, recommendations for future research to facilitate the development and implementation of practical, evidence-based strategies for adherence promotion in IBD are provided. Findings from the literature review suggest that strategies including education, regimen simplification, and use of reminder systems and organizational strategies (e.g., pill boxes) are likely to be best suited for addressing accidental nonadherence. In contrast, addressing motivational issues, teaching problem-solving skills, and addressing problematic patterns of family functioning are more likely to benefit individuals displaying intentional nonadherence.

Promoting adherence to treatment among individuals affected by inflammatory bowel disease (IBD) is a challenge for health care providers in both pediatric and adult settings. Although interventions to enhance adherence in IBD are still largely in their infancy, some important information about practical strategies to enhance adherence can be gleaned from this literature. The purpose of the current review is threefold. First, the review aims to provide a context for understanding treatment regimen adherence in IBD by briefly reviewing key definitional, measurement, and conceptual challenges in this area. Next, the literature on interventions to enhance adherence is briefly reviewed, followed by a synthesis of practical adherence promotion strategies for use in IBD by health care providers. Strategies are distinguished by the level of evidence supporting their utility as well as by age group. The review concludes with recommendations for future research to facilitate the development and implementation of practical evidence-based strategies for adherence promotion in IBD, with an emphasis on illustration of next steps using examples from ongoing research or clinical practice.

Back to Top | Article Outline

DEFINING ADHERENCE

Over the past several decades, terminology regarding patient management of chronic conditions has evolved considerably. “Compliance” is now used less often in reference to the patient's success in following the treatment regimen due to the connotation of patient obedience and blame (i.e., the patient did or did not follow directions) associated with the term. Instead, the term “adherence” is now more commonly used as it connotes a more positive interpretation of patient behavior, reflects the ideal collaboration between patients and providers in treatment planning, and implies a continuum of behavior related to treatment completion. Various definitions of adherence have been proposed; however, the vast majority of these are derivations of the Haynes1 definition: “The extent to which a person's behavior (in terms of taking medications, following diets, or executing lifestyle changes) coincides with medical or health advice.” There were distinctions drawn between intentional or volitional nonadherence, in which patients/families make an informed decision to not adhere to a particular regimen versus accidental nonadherence, in which the intention to adhere to the regimen is present, but practical issues interfere with adherence, such as forgetting.2 Importantly, these definitions conceptualize adherence as an outcome or mediator of disease outcomes, as adherence essentially refers to a quantification of self-management behaviors. The term “self-management,” then, is defined as “the interaction of health behaviors and related processes that patients and families engage in to care for a chronic disease.”3 This definition accounts for the interaction of cognitive and behavioral processes in patients and their families as well. Thus, patient self-management behavior results in the extent to which he/she is adherent, which may consequently have implications for clinical/disease outcomes. Notably, these definitions take into account both the patient and his/her family environment. This is particularly important in pediatrics, as parents often have a substantial role in self-management behavior. However, it may also be a relevant consideration in adult health care because adult patients also often benefit from family support for illness management and self care.

Back to Top | Article Outline

THE NEED FOR ADHERENCE PROMOTION INTERVENTIONS IN IBD

Interventions to enhance oral medication adherence in IBD are warranted given the pervasive nature of nonadherence in both adult and pediatric IBD populations. Between 43% and 60% adults with IBD are nonadherent to their prescribed oral medication regimen.4,5 Furthermore, nonadherent adults are 5.5 times more likely to experience a disease flare than are their adherent counterparts.4 Nonadherence estimates vary across pediatric IBD studies, depending upon medication type, complexity of regimen, and method of adherence assessment, with objective approaches typically yielding higher nonadherence estimates than subjective approaches.6,7 Among studies using self-report methodology, prevalence of oral medication nonadherence as low as 2% has been reported,8 whereas studies using objective methods report nonadherence ranging from 38% to 66%.8–10 Despite this variability, the pediatric IBD literature is similar to the adult literature in supporting that nonadherence has noteworthy consequences for disease activity,11 greater health care utilization,10 and poorer health-related quality of life.7 In addition to the negative impact of nonadherence on disease outcomes, it also has implications for rising health care costs and clinical trial research.5−12

Back to Top | Article Outline

CHALLENGES IN PROMOTING ADHERENCE IN IBD

Several barriers to enhancing adherence in IBD exist. Because adherence is a multifaceted construct, determining the most appropriate time frame and assessment approach poses challenges to clinical researchers seeking to obtain accurate measurements of adherence.

Cognitive and physical developmental issues must be considered when assessing adherence and providing treatment for nonadherence. Our clinical and research experience with the IBD population has provided some insight into these developmental issues across age groups. Young children may not understand why they must take daily medication, which has the potential to result in oppositional behavior related to the medication regimen. Adolescents generally have the cognitive capacity to understand the rationale for long-term medication use, but often desire to be “normal” and not burdened by the demands of their treatment regimens, which may interfere with medication taking particularly when around peers or when taking the medication may interfere with other activities. The expectation for transition-aged youth to take on more independence for medication taking assumes adequate skill in this area. However, when youth have not had an adequate opportunity to learn about their regimen or to develop an organization system to support adherence during early adolescence and midadolescence, they may struggle to successfully adhere to their regimen when expected to do so autonomously at a later point. Both young and middle-age adults may have multiple responsibilities that present barriers to adherence including work responsibilities and child-rearing responsibilities, whereas older adults may experience cognitive declines that may interfere with treatment adherence.13 Thus, assessment and treatment for youth should consist of obtaining estimates of adherence from multiple reporters (e.g., patients and parents) to supplement objective measures; intervention would involve both the patient and his/her parents to focus on the impact of shared responsibility of treatment adherence and increasing autonomy of patient self care. In adults, assessment and treatment may be more or less patient-focused depending on the individual's particular circumstances. Assessment and treatment for young and middle-age adults may involve only the patient or patient and spouse, whereas the inclusion of adult children or other caregivers may be an important component of adherence promotion of older adults. Regardless of patient age, a comprehensive understanding of how the patient manages his/her regimen and who provides support is critical for determining what type of intervention strategies to employ.

Objective methodology such as electronic monitoring, pill counts, analysis of drug metabolites, and the use of pharmacy refill data is commonly preferred over subjective approaches to measuring assessment within the adult14,15 and pediatric IBD literature,6,8 given that it is less prone to social desirability and recall bias. In fact, a recent study comparing teen self-reported adherence to electronic monitoring of adherence found that nonadherent youth are at risk of overestimating oral medication adherence by 23%.6 In addition to providing a more precise adherence estimate in contrast to self-report data, electronic monitoring allows researchers to acquire continuous and long-term data in real time.12,16 This is essential to adherence assessment among individuals with chronic conditions given the data to suggest that adherence is lower overall among those with chronic illness in contrast to individuals with acute conditions and because adherence is not static across time.17 Adherence tends to diminish over time among adult populations, with pronounced declines after the first 6 months,17 and similar rates of decline are observed among youths as they approach adolescence.12 Moreover, diseases such as IBD pose added obstacles to accurate adherence measurement, given that medication must be administered during both active and quiescent phases of the disease.18 However, electronic monitoring is not free of limitations, as device malfunctions can occur and, similar to pill count or pharmacy data assessment methods, it cannot assure that medication was ingested by the patient.12,16 Moreover, concerns related to reactive measurement effects necessitate that researchers take precautions (e.g. building a time frame into the early measurement period during which electronic data will be excluded) when electronic monitoring methodology is used.19 Finally, given the cost associated with electronic monitoring devices, clinical application of this methodology is limited. Thus, as a result of the lack of a gold standard for assessing oral medication adherence, researchers have suggested the use of at least 2 methods of adherence assessment.16 This has the potential to be applied in clinical contexts in which both patient and collateral reports of adherence are obtained, or through the use of pill counts, pharmacy refill data, or bioassays as available to supplement patient self-report.

Back to Top | Article Outline

INTERVENTIONS TO ENHANCE ADHERENCE IN IBD

Interventions to enhance adherence is complicated by the aforementioned conceptual and methodological challenges in adherence assessment. Nonetheless, systematic examination of strategies to enhance adherence is imperative given the high rates of nonadherence in IBD and the significant individual and societal costs associated with nonadherence. The literature on interventions to enhance adherence in IBD is small. Table 1 summarizes key components of each of these studies. Existing adherence interventions have disproportionately focused on adults with ulcerative colitis (UC) and on enhancing adherence to oral IBD maintenance medications. Moreover, existing interventions have primarily focused on demonstrating intervention efficacy rather than effectiveness. Efficacy studies seek to demonstrate that an intervention works under highly controlled circumstances, whereas effectiveness studies examine the impact of interventions under conditions that more closely approximate real life. Given the focus on efficacy trials, issues related to intervention cost-effectiveness, time commitment required of the provider, and training level required of interventionists have been considered less frequently, making the practical application of such approaches challenging to evaluate.

TABLE 1
TABLE 1
Image Tools
TABLE 1
TABLE 1
Image Tools
TABLE 1
TABLE 1
Image Tools

Existing intervention approaches to enhance adherence in IBD can be broadly grouped into 4 categories: educational, behavioral, cognitive behavioral, and multicomponent interventions. Within each domain, interventions vary with respect to the extent to which technology is used in the delivery of the intervention, whether the intervention is delivered individually or in a group setting, and the intensity and duration of the intervention.

Back to Top | Article Outline

EDUCATIONAL INTERVENTIONS

Educational interventions aim to enhance patient knowledge of IBD and symptoms, the benefits and mechanisms of action of the medication regimen, the consequences of nonadherence, and potential side effects of treatment. Furthermore, educational interventions typically involve provision of information on the medication dosing schedule.

One educational intervention to enhance adherence in IBD were developed and evaluated in adult populations. Waters et al20 evaluated the efficacy of a 4-session group educational intervention delivered by a gastroenterology (GI) nurse practitioner. Results demonstrated a statistically nonsignificant trend toward lower rates of missed medication in the intervention group compared with a standard care comparison group over time. No interventions that focus exclusively on education as a mechanism of adherence promotion in pediatric IBD have been published.

Back to Top | Article Outline

BEHAVIORAL INTERVENTIONS

Behavioral interventions promote the act of medication taking and/or reinforce adherence by providing incentives for medication taking or altering environmental antecedents and contingencies associated with medication taking. Examples of behavioral interventions include simplification of the regimen, use of visual or auditory reminder systems, and use of behavioral contracting or reward systems for taking medication as prescribed.

Regimen simplification interventions were evaluated in 2 studies of adult IBD populations.21,22 Kane et al21 randomized adults with UC to either once daily dosing (QD) or a conventional regimen (2 or 3 times daily dosing). At 3 months after initiation of the trial, all patients in the QD group were adherent, whereas only 70% of patients in the conventional dosing group were adherent. Although the benefit of once daily dosing decreased by 6-month follow-up, consumption remained significantly higher in the QD group. Additionally, Dignass et al22 found that the remission rate was significantly higher among adults given a QD dose of mesalazine compared with those dosed twice daily. Patient report suggested higher adherence in the QD group, likely contributing, in part, to the difference in remission rates. No interventions that focus exclusively on behavioral strategies to improve adherence in pediatric IBD have been published.

Back to Top | Article Outline

COGNITIVE BEHAVIORAL INTERVENTIONS

Cognitive behavioral interventions enhance adherence by altering thinking patterns that contribute to nonadherence while also establishing behavioral patterns that support adherence using aforementioned behavioral strategies. Problem-solving skills training is a cognitive behavioral modality that aims to enhance adherence via teaching individuals a structured framework for identifying barriers to adherence, generating and evaluating the likely impact of solutions, and implementing the solution that is most likely to resolve the adherence barrier.23

Although cognitive behavioral interventions have not been evaluated among adult IBD populations, 1 recent study used problem-solving skill training among a sample of youth with IBD (Table 1). Specifically, Greenley et al24 evaluated a 2-session phone-delivered family problem-solving skills training intervention among a group of 31 youths. Results suggested adherence improved by 10% for the full sample and by 18% among those with imperfect baseline adherence.

Back to Top | Article Outline

MULTICOMPONENT INTERVENTIONS

Multicomponent interventions use multiple strategies to enhance adherence including educational, behavioral, cognitive behavioral, motivational, and/or support provision strategies. Muticomponent interventions are advantageous insofar as they maximize the likelihood of an intervention effect by using a variety of theoretically or empirically based approaches to enhancing adherence. However, they do not allow for isolation of which specific intervention components are necessary to enhance adherence.

Evidence exists to support that multicomponent interventions can enhance adherence in adults with UC on 5-ASAs25–27 and in youth with IBD on thiopurines and aminosalycilates.28,29

Four studies support the efficacy of multicomponent interventions for adults with IBD. First, Elkjaer et al25 documented higher levels of adherence to a 4-week acute 5-ASA treatment protocol in adult patients with UC participating in the intervention compared with those in the comparison group. Intervention components included web-based education, individualized feedback on symptom severity, and suggested medication regimen adjustments through an automated system, and opportunities for interaction with a physician via electronic means (e.g. e-mail, text message, or through the study Website). Additionally, Cross and colleagues developed the UC HAT program for adults with UC.26,27 Their results documented higher adherence to those in the intervention group at 12 months after intervention relative to a control group; however, there were no differences between intervention and control groups at 4 or 8 months after intervention. Intervention components included patient education, individualized and automated feedback on patient symptoms, and follow-up phone contact with nurses to alter the medication regimen when clinically indicated based on symptom profiles. Third, Cook et al18 evaluated a telephone nurse counseling intervention for patients with UC and found that rates of adherence over the 6 months following the intervention were higher than published rates of adherence in this population, supporting the intervention's efficacy. Intervention components included education, motivational interviewing strategies, and cognitive behavioral techniques. Finally, Moshkovska et al30 examined the impact of a tailored patient preference intervention on adherence to 5-ASAs among adults with UC. Significantly higher rates of adherence were documented after intervention in the intervention group compared with the control group. Intervention components were tailored to each individual's preferences. All participants were provided with education and motivational enhancement training during an initial call and 2 follow-up calls. Additionally, participants chose up to 3 additional intervention components including a simplified dosing regimen, a medication reminder chart, visual medication reminders for refrigerator or bedside cabinet, daily pill box organizers with alarms, weekly pill box organizers, weekly nonelectric pill box organizer, or cell phone alarm set up.

Two pediatric studies support the utility of multicomponent interventions for adherence promotion. First, Hommel et al28 evaluated a family-based individually tailored treatment among a group of 14 adolescents. The intervention consisted of four 60- to 75-minute sessions focused on educational and organizational interventions, behavior modification, problem solving, monitoring of adherence, and promoting adaptive family functioning. Youth demonstrated thiopurine adherence increases of 4% and mesalamine adherence increases of 25% from before to after intervention. Second, Hommel et al29 also evaluated a group-based multicomponent intervention among a group of 40 youths aged 11 to 18 years. The intervention consisted of educational/organizational components, behavior modification, problem-solving skills training, monitoring of adherence, and addressing problematic family functioning (i.e., reducing conflict and improving communication). Compared with the no treatment control group, those in the intervention group demonstrated a statistically significant improvement in mesalamine adherence; however, no differences in thiopurine adherence were documented.

Back to Top | Article Outline

PRACTICAL STRATEGIES TO ENHANCE ADHERENCE

In the sections that follow, recommendations for practical strategies to enhance adherence in IBD are provided. Strategies are divided into evidence-based and promising strategies. Evidence-based strategies refer to those that are supported by research as effective intervention approaches in IBD populations. Promising strategies are those supported as useful in multicomponent trials with IBD populations. Recommendations are tailored by age, as appropriate, to highlight relevant developmental considerations in promoting adherence.

Back to Top | Article Outline

EVIDENCE-BASED STRATEGIES

Adult Populations
Back to Top | Article Outline
Education

Educational interventions focused on providing information about IBD, symptoms, and the medication regimen have a beneficial impact on adherence in adults with UC.20 However, enhancing knowledge is likely best conceptualized as a necessary but not sufficient condition for medication adherence, and the combination of behavioral and educational interventions is likely superior to either one alone in enhancing adherence.31 Furthermore, educational interventions are probably most beneficial in addressing accidental nonadherence, which results from misunderstanding of the regimen requirements or organizational difficulty rather than volitional nonadherence.

Back to Top | Article Outline
Dose Simplification

Simplification of the regimen dosing schedule to once per day has improved adherence among adult patients with UC.21,22 This approach is likely most beneficial in addressing accidental nonadherence related to regimen complexity.

Back to Top | Article Outline
Pediatric Populations
Back to Top | Article Outline
Problem-Solving Training

Family-based problem-solving skills training seem to enhance oral medication adherence in youth with IBD.24 Teaching patients how to systematically identify barriers to adherence, develop solutions, and implement these solutions can effectively be done through telephone and thus, have the potential to be integrated into clinical care in this manner. Recent efforts in other pediatric chronic disease populations add additional support for the practical applicability of this approach in documenting that problem-solving skills training can be delivered by health care providers during routine outpatient appointments.32

Back to Top | Article Outline

PROMISING STRATEGIES

All Age Groups
Back to Top | Article Outline
Behavioral Strategies

Behavioral strategies such as visual reminder systems, auditory reminder systems, or use of a weekly or daily pill box are often included in multicomponent adherence promotion interventions in IBD30 and are likely of practical value in enhancing adherence. Reminder systems have been documented to increase adherence between 6% to 25% across other chronic illness groups.33,34 Type of reminder system (phone or pager text message, phone call, video call, interactive voice response system, or electronic monitoring device with integrated reminder alarm) appears to not significantly impact adherence rates.34

Reminder systems are likely most beneficial in addressing accidental nonadherence and may take several forms including visual reminders (e.g., posted notes, placement of pill bottles in conspicuous locations) or auditory reminders (e.g., automated text messages, alarms). Specific reminder systems, which provide specific information about which medication is to be taken at a given time, along with dosing instructions, are likely to be most helpful.

Back to Top | Article Outline
Enhancing Patient–Provider Communication

Enhancing the quality of the patient–provider relationship has the potential to enhance adherence in IBD. Interventions in adults with UC that have included individual interaction with health care professionals as 1 part of a multicomponent intervention suggest this as a promising approach.25–27 Additionally, descriptive research corroborates the importance of the patient–provider relationship in suggesting that nonadherence is more frequent when there is discordance between patient and physician, a phenomenon documented among adults with IBD35 and other illness groups.36,37 In contrast, specific provider behaviors that may enhance adherence include a collaborative style of interaction, open discussion of the patient's level of knowledge about their regimen, and discussion about the patient's beliefs about the acceptability and necessity of the medication, concerns related to taking medication, and perceived impact of IBD on their functioning.38–40

Back to Top | Article Outline
Adult Populations
Back to Top | Article Outline
Individualized Feedback on Symptoms

Results from several multicomponent adult intervention trials support the value of providing patients with recommendations for medication adjustments tailored to their symptom profiles.25–27 Although in the context of extant studies feedback was delivered through automated systems, it seems reasonable to expect that specific feedback about benefits of adjusting medication dosing schedules based on current symptoms and the importance of adherence to the schedules could be done during routine clinic appointments or phone follow-ups with patients as well. Providing patients with feedback on symptoms and necessary medication adjustments between appointments is likely to be of benefit to individuals who experience volitional nonadherence related to misinterpretation of symptoms as medication side effects or for those who view medications as unlikely to benefit their disease functioning in a specific way. Additionally, feedback may also serve to improve accidental nonadherence insofar as it offers an opportunity for providers to provide clarification about the expected medication dosing regimen.

Back to Top | Article Outline
Motivational Enhancement

Several adult adherence promotion trials in IBD have incorporated motivational interviewing techniques to enhance adherence as one of multiple intervention components.18,30 Motivational interviewing strategies seek to help an individual identify their core values/goals and to increase the patient's insight regarding the role of medication adherence in achieving their goals. Motivational interviewing is effective in promoting behavior change in multiple areas including substance use/abuse, HIV-risk prevention, diet, and exercise, as well as medication adherence in other chronic illness groups.41–43 Specific techniques used to enhance motivation include the following: (1) conveying a nonjudgmental understanding of the patient's perspective, (2) working with the patient to see a discrepancy between their personal goals (e.g., returning to work, being socially active) and their present behavior (e.g., not taking medication as prescribed), (3) treating resistance to change as normal, and (4) supporting patient self efficacy development. Motivational enhancement may be particularly useful in addressing volitional nonadherence. In contrast, patients who are already invested in being adherent but experience barriers to adherence that are contextual in nature (e.g., lack of organized system and financial barriers to getting medication refilled consistently) may be less likely to benefit from motivational enhancement strategies.

Back to Top | Article Outline
Problem-Solving Training

As previously indicated, problem-solving skills training, has some support for effectiveness in pediatric trials.24,28,29 Problem solving has also been a component of several adult IBD adherence promotion interventions.18 Problem-solving training is a strategy that has the potential to address both volitional and accidental nonadherence given that the process of problem solving involves identifying barriers specific to an individual.

Back to Top | Article Outline
Pediatric Populations
Back to Top | Article Outline
Enhancing Knowledge

Enhancing knowledge is a useful stand-alone intervention to improve adherence among adults with IBD20 and educational interventions are often used in conjunction with other methods of intervention in both adult and pediatric adherence promotion trials.25–29 As such, enhancing knowledge may help to improve adherence in pediatric IBD. One recent descriptive study in pediatric IBD offers some support for this supposition. Specifically, Greenley et al found that higher levels of youth knowledge about the reason for nutritional supplementation in IBD were associated with higher supplement adherence rates (Greenley, Stephens, Nguyen, et al., unpublished data, 2012). Whereas in adult populations, patient education may be sufficient, given that treatment management regimen responsibilities for youth often fall on parents and children, family-based education approaches are important to maximize the likelihood of adherence and should focus on providing information in written and verbal formats. Knowledge about the names of medications, dosing schedules, mechanisms of action, and potential side effects is imperative, as is provision of information about likely benefits of medication even during times of disease remission (for maintenance medications). Educational interventions are likely to be most beneficial in addressing accidental nonadherence that results from misunderstandings of dosing schedules or regimen components or in addressing volitional nonadherence related to a lack of perceived benefit of taking medication during times of symptom remission.

Back to Top | Article Outline
Dose Simplification

Simplification of dosing regimen may be another useful intervention in pediatric populations, given this strategy has been associated with improved adherence in adult IBD populations and in other chronic illness groups.21,22,33,44,45 Across chronic illness groups, once or twice daily dosing has been associated with significantly higher regimen adherence than 3 or 4 time daily dosing.22,44,45 Dose simplification is likely to be most beneficial in the context of accidental nonadherence, as it assumes the patient is motivated to take the medication as prescribed.

Back to Top | Article Outline
Behavioral Management

Behavior management strategies such as development of reward systems for taking medication as prescribed, or behavioral contracting in which privileges are awarded or rescinded based on medication taking behavior is a promising intervention approach in pediatric populations that has been included in multicomponent pediatric IBD adherence enhancement trials.28,29 These strategies also have been shown to be efficacious in other pediatric disease populations.46 Reward systems or behavioral contracting may be particularly useful for addressing oppositional youth behavior, in counteracting the impact of negative medication side effects on adherence and in addressing low motivation to adhere to maintenance medications in which symptom prevention rather than symptom amelioration is the goal. Rewards for taking medication can take the form of objects (e.g. stickers) or privileges (e.g. having a friend spend the night), and they provide concrete reinforcement for engaging in a task that is otherwise nonrewarding or possibly mildly aversive.12 In general, positive reinforcement is preferred over loss of privileges; however, in cases where positive reinforcement is not sufficient to promote behavior change, loss of privileges can be a useful strategy.12 Rewards should be tied to attainable goals (e.g., earning a reward after taking medication 10 times), rather than less attainable ones (e.g. not missing medication at all for the whole month) and should be developed with youth input to enhance their motivating value.

Back to Top | Article Outline
Increasing the Frequency of Contact with GI Provider

Increasing frequency of contact with provider is another possibly efficacious strategy to promote adherence in pediatric populations. In 1 study, adherence to oral thiopurine medications was significantly higher in the 3 days before, the day of, and the 3 days after a pediatric GI specialty appointment among youths aged 11 to 18 years with IBD (Nguyen et al., unpublished data, 2012).

Back to Top | Article Outline
Promoting Adaptive Family Functioning

Several multicomponent adherence promotion interventions in pediatric IBD address family communication deficiencies and teach family conflict resolution skills as methods of enhancing adherence.28,29 Additionally, high levels of family involvement in condition management may serve to enhance adherence in pediatric IBD. In 1 study, youth who reported being “involved almost all the time” in taking their daily medication were significantly less likely to be nonadherent.6 However, a high level of youth involvement in the absence of high levels of parent involvement is not expected to enhance adherence. Rather, high levels of both youth and parent involvement in disease management have been supported as advantageous for adherence in other pediatric populations.47–49 Similarly, in a recent study, families of youth with IBD categorized as having both high youth and paternal involvement had significantly higher aggregate adherence ratings over time than did families with high involvement of just 1 person or low involvement of both (Greenley, Thomason, Kunz, unpublished data, 2012).

Back to Top | Article Outline

FUTURE DIRECTIONS

Target Interventions to At-Risk Groups

One important direction for future research involves targeting adherence interventions to at-risk populations. A movement away from universal interventions (i.e., those in which the entire population of individuals with IBD are potentially targeted) toward more focused interventions acknowledges the limited resources available for intervention and ensures that those most in need of intervention are most likely to receive it. Several risk factors for nonadherence have been identified in demographic, disease-related, and individual functioning domains. Attention to these risk factors may elucidate subgroups that may benefit from more targeted intervention approaches.

Demographic risk factors for nonadherence from the adult literature include being male, single, being employed full time, and having a higher education level.15,50–55 Demographic factors have not consistently emerged as risk factors for nonadherence in pediatric populations.

Disease-related risk factors for nonadherence across both adult and pediatric populations include quiescent disease.10,18,21,26,51 Adult patients with longer standing disease are also less likely to be adherent.51,56 Additionally, aspects of the disease management regimen have been documented as risk factors for nonadherence. Understandably, patients have more difficulty with adherence when they are on multiple medications and are required to take medication more than once per day.51,55,56 Unknown or known side effects of the medications, such as headaches or nausea can also negatively affect adherence.18,56 However, it is important to note that those patients actually experiencing adverse drug events tend to be adherent if they believe their treatment is beneficial.18

Individual psychological dysfunction has also been documented as a risk factor for nonadherence in pediatric and adult groups. Depressive symptoms have been associated with nonadherence in youths and adults with IBD.18,51,57,58 Additionally, anxiety symptoms, anxiety disorders, somatoform disorders, and certain personality disorders have been related to nonadherence in adult populations.30,35,55,57 Among pediatric populations, oppositional and avoidant behaviors have been correlated with nonadherence, as has impaired health-related quality of life.2,7,9,59,60

Research that targets adherence promotion in at-risk groups is an emerging area. To maximize efficient use of clinical resources, it is necessary to identify the patients who are at greatest risk for poor self-management and associated psychosocial dysfunction. Current efforts to examine the psychosocial risk factors that predict poor self-management in a clinical population are underway. The benefit of this research is that we will ultimately know the most salient psychosocial predictors of self-management and disease outcomes so that we can screen for these issues in clinical settings and address them more proactively.

Back to Top | Article Outline
Deconstruct Multicomponent Interventions

Across both adult and pediatric populations, support for the efficacy of several multicomponent interventions exists.18,25–30 Future research, which focuses on deconstructing these multicomponent interventions, would aide in the identification of the intervention component or components that are critical for enhancing adherence. In the context of deconstructing such multicomponent interventions, attention to evaluating the individual impact of low-cost strategies and those that have the potential to be integrated in regular care (e.g., use of pill boxes) would substantially contribute to our understanding of practical strategies.

Back to Top | Article Outline
Determine Which Interventions can be Delivered by Regular Providers or in Real Life Settings

A parallel line of research that would be informative is to examine the extent to which current evidence-based methods of intervention could be delivered by a regular health care provider or could be integrated into routine clinical practice. For example, problem-solving skills training can improve adherence in pediatric IBD populations when delivered through telephone by individuals with backgrounds in behavioral health psychology.24 A logical next step would be to examine the extent to which this intervention remains useful when administered by nurses over the telephone or when integrated into regular clinic appointments. Because behavioral health services may be limited in certain settings, understanding the extent to which medical providers may be effective in implementing certain interventions may extend availability of adherence promotion resources to a broader range of patients.

As an example, there is a current effort to dismantle the treatment protocol used by Hommel et al28 in a clinical setting. This involves testing individual components of the protocol across multiple patients to determine which components have the greatest impact on medication adherence. This is an excellent example of the type of translational research that needs to occur to make research clinical trials clinically relevant (applicable to patients who present with multiple comorbidities, greater complexity of behavioral difficulties, etc.).

Back to Top | Article Outline
Use Existing Technology

Similarly, interventions that incorporate freely available technology (e.g. smart phone application medication reminder systems) have the potential to be incorporated into routine clinical care and/or to reach a population of patients for whom it would be difficult to participate in face-to-face interventions. For example, in an ongoing multisite trial, Hommel and colleagues are applying their in-person intervention to promote medication adherence through virtual face-to-face technology. They will evaluate the impact of this treatment, being delivered through Skype, on medication adherence and disease outcomes. The benefit of this telehealth approach is that the treatment can be delivered to anyone in the world without requiring the patient and provider to be physically at the same location, which is a clear benefit to a large number of patients and clinicians who do not have access to this type of clinical intervention at their treatment facility.

Back to Top | Article Outline
Expand Focus Beyond Oral Medication Adherence

Expanding interventions to focus on more than just oral medication adherence is an imperative next step. Some preliminary data from pediatric populations suggest that nonadherence to nutritional supplements is poor among youths with IBD, with rates below 50% (Greenley, Stephens, Nguyen, et al., unpublished data, 2012). Additionally, recent data from the adult IBD literature suggest that adherence to infusion treatment is suboptimal.61 Attention to enhancing adherence to all aspects of IBD management is important in promoting optimal disease functioning broadly.

Back to Top | Article Outline

CONCLUSIONS

Promoting adherence to treatment among patients with IBD is a challenging yet important task. Health professionals are in a unique role to facilitate optimal adherence given their ongoing interactions with patients. Effective intervention starts with an accurate assessment of adherence, which we recommend include collateral reports, pill counts, and bioassay measures to the extent possible. Once baseline levels of adherence are ascertained, exploration of barriers to adherence is critical to identify volitional and accidental reasons for nonadherence, as each may benefit from different intervention approaches. Interventions should be tailored to the specific barriers to adherence for the individual patient, and developmental factors should be considered in the choice of intervention approach. Strategies including education, regimen simplification, and use of reminder systems or organizational strategies (e.g. pill boxes) are likely to be best suited for addressing accidental nonadherence. In contrast, addressing motivational issues, teaching problem-solving skills, and addressing problematic patterns of family functioning are more likely to benefit individuals displaying intentional nonadherence. Although these strategies appear promising in promoting adherence in IBD, much more work is needed to translate existing interventions into clinical practice and to develop additional practical strategies to enhance adherence in IBD.

Back to Top | Article Outline

REFERENCES

1. Haynes RB. Introduction. In: Haynes RB, Taylor DW, Sackett DL., eds. Compliance in Health Care. . Baltimore, MD: Johns Hopkins University Press; 1979; :1–7.

2. Schurman JV, Cushing CC, Carpenter E, et al. Volitional and accidental nonadherence to pediatric Inflammatory Bowel Disease treatment plans: initial investigation of associations with quality of life and disease activity. J Pediatr Psychol. 2011; 36:116–125.

3. Modi AC, Pai AL, Hommel KA, et al. Pediatric self-management: a framework for research, practice, and policy. Pediatrics. 2012; 129:e473–e485.

4. Kane S, Huo D, Aikens J, et al. Medication nonadherence and the outcomes of patients with quiescent ulcerative colitis. Am J Med. 2003; 114:39–43.

5. Kane S, Shaya F. Medication non-adherence is associated with increased medical health care costs. Dig Dis Sci. 2008; 53:1020–1024.

6. Greenley RN, Kunz JH, Biank V, et al. Identifying adolescent nonadherence in clinical settings: data-based recommendations for children and adolescents with inflammatory bowel disease. Inflamm Bowel Dis. 2012; 18:1254–1259.

7. Hommel KA, Davis CM, Baldasano RN. Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol. 2008; 33:867–874.

8. Hommel KA, Davis CM, Baldassano RN. Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2009; 15:589–593.

9. Ingerski LM, Baldassano RN, Denson LA, et al. Barriers to oral medication adherence for adolescents with inflammatory bowel disease. J Pediatr Psychol. 2010; 33:683–691.

10. Oliva-Hemker MM, Abadom V, Cuffari C, et al. Nonadherence with thiopurines immunomodulator and mesalamine medications in children with Crohn's disease. J Pediatr Gastroenterol Nutr. 2007; 44:180–184.

11. Hommel KA, Denson LA, Baldassano RN. Oral medication adherence and disease severity in pediatric inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2011; 23:250–254.

12. Rapoff MA. Adherence to Pediatric Medical Regimens. 2nd ed. New York, NY: Springer; 2010; .

13. Kane SV, Robinson A. Review article: understanding adherence to medication in ulcerative colitis—innovative thinking and evolving concepts. Aliment Pharmacol Ther. 2010; 32:1051–1058.

14. Kane SV. Strategies to improve adherence and outcomes in patients with ulcerative colitis. Drugs. 2008; 68:2601–2609.

15. Kane SV, Cohen RD, Aikens JE, et al. Prevalence of nonadherence with maintenance mesalamine in quiescent ulcerative colitis. Am J Gastroenterol. 2001; 96:2929–2933.

16. Quittner AL, Modi AC, Lemanek KL, et al. Evidence-based assessment of adherence to medical treatments in pediatric psychology. J Pediatr Psychol. 2008; 33:916–936.

17. Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005; 353:487–497.

18. Cook PF, Emiliozzi S, El-Hajj D, et al. Telephone nurse counseling for medication adherence in ulcerative colitis: a preliminary study. Patient Educ Couns. 2010; 81:182–186.

19. Cook P, Schmiege S, McClean M, et al. Practical and analytic issues in the electronic assessment of adherence. West J Nurs Res. 2012; 34:598–620.

20. Waters BM, Jensen L, Fedorak R. Effects of formal education for patients with inflammatory bowel disease: a randomized controlled trial. Can J Gastroenterol. 2005; 19:235–244.

21. Kane S, Huo D, Magnanti K. A pilot feasibility study of once daily versus conventional dosing mesalamine for maintenance of ulcerative colitis. Clin Gastroenterol Hepatol. 2003; 1:170–173.

22. Dignass A, Veerman H. Once versus twice daily mesalazine (Pentasa) granules for the maintenance of remission in ulcerative colitis: results from a multi-national randomized controlled trial. Gut. 2008; 57:(suppl 1):A1

23. D'Zurilla TJ, Nezu AM. Problem-Solving Therapy: A Positive Approach to Clinical Intervention. New York, NY: Springer Publishing Company; 2007; .

24. Greenley RN, Nguyen E, Kunz JH, et al. Phone intervention to improve pediatric oral medication adherence: preliminary acceptability and feasibility. Inflamm Bowel Dis. 2011; 17:(S12):S57

25. Elkjaer M, Shuhaibar M, Burisch J, et al. E-health empowers patients with ulcerative colitis: a randomised controlled trial of the web-guided ‘Constant-care’ approach. Gut. 2010; 59:1652–1661.

26. Cross RK, Finkelstein J. Feasibility and acceptance of a home telemanagement system in patients with inflammatory bowel disease: a 6-month pilot study. Dig Dis Sci. 2007; 52:357–364.

27. Cross RK, Cheevers N, Rustgi A, et al. Randomized, controlled trial of home telemanagement in patients with Ulcerative Colitis (UC HAT). Inflamm Bowel Dis. 2012; 18:1018–1025.

28. Hommel KA, Herzer M, Ingerski LM, et al. Individually-tailored treatment of medication nonadherence. J Pediatr Gastroenterol Nutr. 2011; 53:435–439.

29. Hommel KA, Hente EA, Odell S, et al. Evaluation of a group-based behavioral intervention to promote adherence in adolescents with inflammatory bowel disease. Eur J Gastroenterol Hepatol. 2012; 24:64–69.

30. Moshkovska T, Stone MA, Smith RM, et al. Impact of a tailored patient preference intervention in adherence to 5-Aminosalicylic acid medication in ulcerative colitis: results from an exploratory randomized controlled trial. Inflamm Bowel Dis. 2011; 17:1874–1881.

31. Stockwell Morris L, Schulz RM. Patient compliance—an overview. J Clin Pharm Ther. 1992; 17:283–295.

32. Quittner A, Kimberg C, Marciel K, et al. Randomized, controlled trial of a behavioral adherence intervention for adolescents with cystic fibrosis: I change adherence and raise expectations (iCARE). Chest. 2011; 140:908A

33. Krueger KP, Felkey BG, Berger BA. Improving adherence and persistence: a review and assessment of interventions and description of steps toward a national adherence initiative. J Am Pharm Assoc. 2003; 43:668–678.

34. Fenerty SD, West C, Davis SA, et al. The effect of reminder systems of patients’ adherence to treatment. Patient Prefer Adherence. 2012; 6:127–135.

35. Sewitch MA, Abrahamowicz M, Barkun A, et al. Patient nonadherence to medication in inflammatory bowel disease. Am J Gastroenterol. 2003; 98:1535–1544.

36. Donovan JL, Blake DR. Patient non-compliance: deviance or reasoned decision-making. Soc Sci Med. 1992; 34:507–513.

37. Kerse N, Buetow S, Mainous AG, et al. Physician-patient relationship and medication compliance: a primary care investigation. Ann Fam Med. 2004; 2:455–461.

38. Hall NJ, Rubin GP, Dougall A, et al. The fight for ‘health-related normality’: a qualitative study of the experiences of individuals living with established inflammatory bowel disease. J Health Psychol. 2005; 10:443–455.

39. Hawthorne AB, Rubin G, Ghosh S. Review article: medication non-adherence in ulcerative colitis—strategies to improve adherence with mesalazine and other maintenance therapies. Aliment Pharmacol Ther. 2008; 27:1157–1168.

40. Hommel KA, Denson LA, Crandall WV. Behavioral functioning and treatment adherence in pediatric inflammatory bowel disease: review and recommendations for practice. Gastroenterol Hepatol (N Y). 2008; 4:785–790.

41. Lundahl B, Burke BL. The effectiveness and applicability of motivational interviewing: a practice friendly review of four meta-analyses. J Clin Psychol. 2009; 65:1232–1245.

42. Smith DE, Heckemeyer CM, Kratt PP, et al. Motivational interviewing to improve adherence to a behavioral weight-control program for older obese women with NIDDM: a pilot study. Diabetes Care. 1997; 20:152–154.

43. DiIori C, Resnicow K, McDonnell M, et al. Using motivational interviewing to promote adherence to antiretroviral medications: a pilot study. J Assoc Nurses AIDS Care. 2003; 14:52–62.

44. Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther. 2001; 23:1296–1310.

45. Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin Ther. 1984; 6:592–599.

46. Kahana S, Drotar D, Frazier T. Meta-analysis of psychological interventions to promote adherence to treatment in pediatric chronic health conditions. J Pediatr Psychol. 2008; 33:590–611.

47. Anderson BJ, Auslander WF, Jung KC, et al. Assessing family sharing of diabetes responsibilities. J Pediatr Psychol. 1990; 15:477–492.

48. Wysocki T, Gavin L. Paternal involvement in the management of pediatric chronic diseases: associations with adherence, quality of life, and health status. J Pediatr Psychol. 2006; 31:501–511.

49. Vesco AT, Anderson BJ, Laffel LMB, et al. Responsibility sharing between adolescents with type 1 diabetes and their caregivers: importance of adolescent perceptions on diabetes management and control. J Pediatr Psychol. 2010; 35:1168–1177.

50. Cerveny P, Bortlik M, Kubena A, et al. Nonadherence in inflammatory bowel disease: results of factor analysis. Inflamm Bowel Dis. 2007; 13:1244–1249.

51. San Roman AL, Bermejo F, Carrera E, et al. Adherence to treatment in inflammatory bowel disease. Rev Esp Engerm Dig. 2005; 97:249–257.

52. Bernal I, Domenech E, Garcia-Planella E, et al. Medication-taking behavior in a cohort of patients with inflammatory bowel disease. Dig Dis Sci. 2006; 51:2165–2169.

53. D’Inca R, Bertomoro P, Mazzocco K, et al. Risk factors for non-adherence to medication in inflammatory bowel disease patients. Aliment Pharmacol Ther. 2008; 27:166–172.

54. Ediger JP, Walker JR, Graff L, et al. Predictors of medication adherence in inflammatory bowel disease. Am J Gastroenterol. 2007; 102:1417–1426.

55. Shale MJ, Riley SA. Studies of compliance with delayed-release mesalazine therapy in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2003; 18:191–198.

56. Greenley RN, Doughty A, Raboin T, et al. Barriers to adherence among adolescents with inflammatory bowel disease. Inflamm Bowel Dis. 2010; 16:36–41.

57. Nigro G, Angelini G, Grosso SB, et al. Psychiatric predictors of noncompliance in inflammatory bowel disease. J Clin Gastroenterol. 2001; 32:66–68.

58. Gray WN, Denson LA, Baldassano RN, et al. Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. J Pediatr Psychol. 2011; 1:1–10.

59. Hommel KA, Baldassano RN. Brief Report: Barriers to treatment adherence in pediatric inflammatory bowel disease. J Pediatr Psychol. 2010; 35:1005–1010.

60. Mackner LM, Crandall WV. Oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis. 2005; 11:1006–1012.

61. Kane SV, Chao J, Mulani PM. Adherence to infiximab maintenance therapy and health care utilization and costs by Crohn’s disease patients. Adv Ther. 2009; 26:936–946.

Keywords:

inflammatory bowel disease; adherence; intervention; review

Copyright © 2013 Crohn's & Colitis Foundation of America, Inc.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.