Skip Navigation LinksHome > September 2014 - Volume 20 - Issue 9 > Influence of Exclusive Enteral Nutrition Therapy on Visceral...
Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0000000000000114
Original Clinical Articles

Influence of Exclusive Enteral Nutrition Therapy on Visceral Fat in Patients with Crohn's Disease

Li, Yi MD, PhD; Zhu, Weiming MD, PhD; Gong, Jianfeng MD, PhD; Zuo, Lugen MD; Zhang, Wei MD, PhD; Gu, Lili MD, PhD; Guo, Zhen MD; Cao, Lei MD; Li, Ning MD; Li, Jieshou MD

Collapse Box

Abstract

Background:

Mesenteric fat plays an important role in the pathogenesis of Crohn's disease (CD), and a higher ratio of visceral fat area (VFA) to subcutaneous fat area (SFA) is related to complicated disease status. Exclusive enteral nutrition (EEN) is an effective treatment option for patients with CD, and the aims of this study were to assess the effects of EEN on abdominal fat in patients with CD.

Methods:

Patient data were obtained from a prospectively maintained database. The SFA and VFA were measured in 38 patients with CD before and after 8-week EEN therapy, and the mesenteric fat index (MFI), defined as the ratio of VFA to SFA, was calculated. The correlations between MFI and CD activity index and C-reactive protein level were also evaluated.

Results:

The median age of the patients in our study was 29 years, and the median duration of disease was 3.05 years. Both VFA (P = 0.029) and MFI (P = 0.021) were significantly decreased in patients after EEN, but no significant change was observed in SFA (P = 0.335). MFI was significantly correlated with CD activity index (r = 0.523, P = 0.001) and C-reactive protein (r = 0.634, P < 0.0001) in patients with active CD before EEN, although no positive correlations were observed in patients after EEN treatment.

Conclusions:

EEN induction therapy was associated with a significant decrease in VFA in patients with CD, and MFI was significantly correlated with CD activity index and C-reactive protein in active CD. Thus, our data reveal additional beneficial therapeutic mechanisms of enteral nutrition treatment in CD.

Copyright © 2014 Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.