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Association Between Parkinson's Disease and Inflammatory Bowel Disease: a Nationwide Taiwanese Retrospective Cohort Study

Lin, Jung-Chun MD; Lin, Chin-Sheng MD; Hsu, Chin-Wang MD; Lin, Cheng-Li MSc; Kao, Chia-Hung MD

doi: 10.1097/MIB.0000000000000735
Original Article

Objectives: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder. Previous studies have suggested that chronic systemic inflammation increases the risk of Parkinson's disease (PD). This study examined the effects of IBD on the development of PD.

Methods: In a nationwide population-based cohort of 23.22 million insured residents of Taiwan aged ≥ 20 years, we compared people diagnosed with IBD during 2000 to 2011 (n = 8373) with IBD-free individuals. Patients with PD were identified in the National Health Insurance Research Database. Using univariable and multivariable Cox proportion hazard regression models, we estimated the adjusted hazard ratio (aHR) for PD with a 95% confidence interval (CI) with adjustment for age, sex, and comorbidities.

Results: In the cohort, IBD was associated with an increased incidence of PD (crude hazard ratio = 1.43, 95% CI = 1.15–1.79). The risk was highest among individuals with Crohn's disease (aHR = 1.40, 95% CI = 1.11–1.77). In the multivariable model, the risk of PD was increased for men (aHR = 1.28, 95% CI = 1.05–1.56) and higher for patients with hypertension (aHR = 1.72, 95% CI = 1.33–2.24), coronary artery disease (aHR = 1.31, 95% CI = 1.04–1.66), or depression (aHR = 2.51, 95% CI = 1.82–3.46).

Conclusions: We suggest that IBD is associated with an increased risk of PD. Patients with IBD should be aware of the potential risk for PD development.

Article first published online 26 February 2016.

*Division of Gastroenterology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;

Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;

Department of Emergency Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan;

§Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;

Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;

College of Medicine, China Medical University, Taichung, Taiwan;

**Graduate Institute of Clinical Medical Science and School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan; and

††Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.

Reprints: Chia-Hung Kao, MD, Professor, Graduate Institute of Clinical Medical Science and School of Medicine, China Medical University, Taichung, Taiwan. No. 2, Yuh-Der Road, Taichung 404, Taiwan (e-mail: d10040@mail.cmuh.org.tw).

The authors have no conflicts of interest to disclose.

Received November 23, 2015

Accepted December 15, 2015

© Crohn's & Colitis Foundation of America, Inc.
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