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Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0000000000000052
Original Clinical Articles

Outcome After Discontinuation of TNFα-blocking Therapy in Patients with Inflammatory Bowel Disease in Deep Remission

Molander, Pauliina MD*; Färkkilä, Martti MD, PhD†,‡; Salminen, Kimmo MD, PhD§; Kemppainen, Helena MD, PhD§; Blomster, Timo MD; Koskela, Ritva MD, PhD; Jussila, Airi MD; Rautiainen, Henna MD, PhD**; Nissinen, Markku MD, PhD††; Haapamäki, Johanna MD, PhD†,††; Arkkila, Perttu MD, PhD; Nieminen, Urpo MD, PhD; Kuisma, Juha MD, PhD‡‡; Punkkinen, Jari MD, PhD§§; Kolho, Kaija-Leena MD, PhD‖‖; Mustonen, Harri DSc¶¶; Sipponen, Taina MD, PhD

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Abstract

Background:

Few data are available on the disease course in patients with inflammatory bowel disease (IBD) in deep remission after discontinuing tumor necrosis factor α (TNFα)–blocking therapy. In this prospective multicenter study, we evaluated the relapse rate, predictive factors, and the response to retreatment after discontinuation of TNFα-blocking therapy in patients with IBD in deep remission.

Methods:

We recruited 52 patients (17 Crohn's disease, 30 ulcerative colitis, and 5 IBD unclassified) in clinical, endoscopic, and fecal calprotectin-based (<100 μg/g) remission after at least 1 year of TNFα-blocking therapy. Clinical and endoscopic remission and relapse were defined according to validated indices. After discontinuation of therapy, the patients were followed up with endoscopic assessment at 4 and 12 months. In the event of a clinical relapse with endoscopically active disease or minor clinical symptoms but severe endoscopic relapse, TNFα-blocking therapy was restarted.

Results:

After a median follow-up time of 13 (range, 12–15) months, 17/51 (33%) patients relapsed (5/17 Crohn's disease, 12/34 ulcerative colitis/IBD unclassified, 1 patient lost to follow-up at 6 mo). Ten experienced clinical and endoscopic relapse, 5 clinical relapse with mild endoscopic activity, and 2 severe endoscopic relapse. No specific predictive factors were associated with the relapse. Retreatment was effective in 94% of patients.

Conclusions:

After cessation of TNFα-blocking therapy in patients with IBD in deep remission, up to 67% remained in clinical remission during the 12-month follow-up. Importantly, 85% of these patients sustained endoscopic remission. The response to restart of TNFα antagonists was effective and well tolerated.

Copyright © 2014 Crohn's & Colitis Foundation of America, Inc.

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