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Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0000000000000016
Original Clinical Articles

Vitamin D Levels in Adults with Crohn's Disease Are Responsive to Disease Activity and Treatment

Ham, Maggie MD; Longhi, Maria S. MD, PhD; Lahiff, Conor MD; Cheifetz, Adam MD; Robson, Simon MD, PhD; Moss, Alan C. MD

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Abstract

Background:

Vitamin D deficiency is common in patients with Crohn's disease (CD), although whether this impairs immune responsiveness, and is related to disease activity per se, remains unclear. We sought to investigate vitamin D pathways in patients with CD according to measures of inflammation and immune response.

Methods:

Prospectively collected samples of a well-characterized cohort of patients with CD were used to measure serum 25(OH)-vitamin D levels by enzyme-linked immunoassay. Related gene expression was determined by polymerase chain reaction in T cells. The effect of vitamin D on the proliferation of isolated CD4+ cells was determined.

Results:

Patients with active CD had lower serum vitamin D levels than those in clinical remission; this measurement was independent of season or reported use of vitamin D supplements. Harvey–Bradshaw Index scores, but not C-reactive protein, correlated with serum vitamin D levels. Gene expression of the vitamin D receptor was higher in peripheral blood T cells from patients with active disease than in those in remission. The proportion of CD25hi CD4+ cells from patients with CD increased in the presence of vitamin D. After treatment with infliximab, significant increases in serum vitamin D levels were noted in patients.

Conclusions:

Low vitamin D levels are associated with disease activity in CD and increase after infliximab treatment.

Copyright © 2014 Crohn's & Colitis Foundation of America, Inc.

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