Skip Navigation LinksHome > May 2014 - Volume 20 - Issue 5 > Could a Swimming Creature Inform Us on Intestinal Diseases?...
Inflammatory Bowel Diseases:
doi: 10.1097/01.MIB.0000442923.85569.68
Basic Science Review Articles

Could a Swimming Creature Inform Us on Intestinal Diseases? Lessons from Zebrafish

Yang, Ye PhD*; Tomkovich, Sarah BS*,†; Jobin, Christian PhD*,‡

Collapse Box

Abstract

Understanding a complex pathology such as inflammatory bowel disease, where host genetics (innate and adaptive immunity, barrier function) and environmental factors (microbes, diet, and stress) interact together to influence disease onset and severity, requires multipronged approaches to model these numerous variables. Researchers have typically relied on preclinical models of mouse and rat origin to push the boundary of knowledge further. However, incorporation of novel vertebrate models may contribute to new knowledge on specific aspects of intestinal homeostasis. An emerging literature has seen the use of zebrafish as a novel animal system to study key aspects of host–microbe interactions in the intestine. In this review, we briefly introduce components of host–microbiota interplay in the developing zebrafish intestine and summarize key lessons learned from this animal system; review important chemically induced and genetically engineered zebrafish models of intestinal immune disorders; and discuss perspectives and limitations of the zebrafish model system.

Copyright © 2014 Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.