Inflammatory Bowel Diseases

Skip Navigation LinksHome > January 2014 - Volume 20 - Issue 1 > The Role of Macrophages and Dendritic Cells in the Initiatio...
Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0b013e3182a69dca
Basic Science Review Articles

The Role of Macrophages and Dendritic Cells in the Initiation of Inflammation in IBD

Steinbach, Erin C. PhD*; Plevy, Scott E. MD*,†

Collapse Box


Abstract: In the healthy gastrointestinal tract, homeostasis is an active process that requires a careful balance of host responses to the enteric luminal contents. Intestinal macrophages and dendritic cells (DCs) comprise a unique group of tissue immune cells that are ideally situated at the interface of the host and the enteric luminal environment to appropriately respond to microbes and ingested stimuli. However, intrinsic defects in macrophage and DC function contribute to the pathogenesis of inflammatory bowel diseases, as highlighted by recent genome-wide association studies. Gastrointestinal macrophages and DCs participate in inflammatory bowel disease development through inappropriate responses to enteric microbial stimuli, inefficient clearance of microbes from host tissues, and impaired transition from appropriate proinflammatory responses to anti-inflammatory responses that promote resolution. By understanding how intestinal macrophages and DCs initiate chronic inflammation, new pathogenesis-based therapeutic strategies to treat human inflammatory bowel diseases will be elucidated.

© Crohn's & Colitis Foundation of America, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.