Inflammatory Bowel Diseases

Skip Navigation LinksHome > October 2013 - Volume 19 - Issue 11 > Serum M 30 Levels Reflects Ulcerative Colitis Activity
Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0b013e3182a0ea38
Original Clinical Articles

Serum M 30 Levels Reflects Ulcerative Colitis Activity

Aktaş, Bora MD*; Altinbaş, Akif MD*; Başar, Ömer MD*,†; Yilmaz, Bariş MD*; Ekiz, Fuat MD*; Giniş, Zeynep MD; Öztürk, Gülfer MD; Çoban, Şahin MD*; Tuna, Yaşar MD; Uçar, Engin MD*; Erarslan, Elife*; Yüksel, Osman MD*

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Background: Apoptosis plays a role in epithelial and mucosal injury, which is 1 of the mechanisms in the pathogenesis of ulcerative colitis. Apoptotic cells increase as a result of injured mucosa in ulcerative colitis and serum M 30 levels increase in epithelial cell apoptosis. In this study, we aimed to evaluate the relation between M 30 serum levels and ulcerative colitis activity.

Methods: Eighty patients with ulcerative colitis and 40 healthy controls were enrolled into the study. The patient group consisted of 31 extensive colitis, 30 left-sided colitis, and 19 proctitis. The activity of ulcerative colitis was determined with clinical and endoscopic findings. Serum M 30 levels, acute phase reactants, and biochemical tests were analyzed in all subjects.

Results: Serum M 30 levels in patients with active ulcerative colitis were significantly higher when compared with the healthy controls (165.6 ± 60.6 and 129.6 ± 37.4; P = 0.003). Serum M 30 levels in active left-sided colitis patients was significantly higher when compared with patients in remission phase (180.6 ± 58.5, 141.5 ± 35.4; P = 0.044). When we exclude patients with ulcerative proctitis, M 30 levels in active ulcerative colitis patients were significantly higher than that the patients in remission phase (174.0 ± 63.5, 135.0 ± 29.9; P = 0.017).

Conclusions: We found that M 30 levels increase in patients with active ulcerative colitis. Our findings support the role of apoptosis demonstrated by serum M 30 levels in the pathogenesis of active ulcerative colitis.

© Crohn's & Colitis Foundation of America, Inc.

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