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Treatment of an Initial Infection with Clostridium difficile in Patients with Inflammatory Bowel Disease

Khanna, Reena MD*; Chande, Nilesh MD; Nelson, Richard L. MD

doi: 10.1097/MIB.0b013e31829b3e1d
Cochrane Review

Abstract: Although the incidence of Clostridium difficile–associated diarrhea in the general population has increased dramatically over the past decade, an even greater rate of infection exists in patients with inflammatory bowel disease. Susceptibility in this population is likely inherent to the pathophysiology and treatment of these diseases. C. difficile infection can cause serious complications and death. Consequently, early diagnosis and initiation of effective antibacterial therapy is imperative. This article evaluates treatment recommendations for an initial episode of C. difficile infection in patients with inflammatory bowel disease based on the current guidelines and a Cochrane systematic review.

Article first published online 7 August 2013

*Department of Medicine, Robarts Research Institute, Western University, London, Ontario, Canada;

Department of Medicine, Division of Gastroenterology, Western University, London, Ontario, Canada; and

Department of General Surgery, Northern General Hospital, Sheffield, United Kingdom.

Reprints: Reena Khanna, MD, Robarts Clinical Trials, Robarts Research Institute, 100 Perth Drive, London, ON, Canada N6A 5K8 (e-mail:

The authors have no conflicts of interest to disclose.

Received April 09, 2013

Accepted May 09, 2013

© Crohn's & Colitis Foundation of America, Inc.
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