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Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0b013e31829bfc26
Original Clinical Articles

Excessive Weight Gain Is Associated with an Increased Risk for Pouch Failure in Patients with Restorative Proctocolectomy

Wu, Xian-Rui MD, PhD*; Zhu, Hong MD; Kiran, Ravi P. MD*; Remzi, Feza H. MD*; Shen, Bo MD

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Abstract

Background: The aim was to evaluate the impact of weight gain on pouch outcomes after ileostomy closure.

Methods: Consecutive inflammatory bowel disease patients with ileal pouches followed up at our subspecialty Pouch Center from 2002 to 2011 were studied. The association of excessive weight gain (defined as a 15% increase the index weight) with pouch outcomes were evaluated using univariate and multivariate analyses.

Results: A total of 846 patients met inclusion criteria, with 470 (55.6%) being men. The mean age at the diagnosis of inflammatory bowel disease and at pouch surgery was 27.2 ± 11.9 years and 37.8 ± 12.8 years, respectively. Patients with weight gain more likely had mechanical or surgical complications of the pouch (18.4% versus 12.3%, P = 0.049), Crohn's disease of the pouch (30.6% versus 18.5%, P = 0.001), Pouch Center visits (2.0 [1.0–4.0] versus 2.0 [1.0–3.0], P = 0.008), and postoperative pouch-related hospitalization (21.1% versus 10.6%, P < 0.001). After a median follow-up of 9.0 (interquartile range = 4.0–14.0) years, 68 patients (8.0%) developed pouch failure. In the multivariate analysis, excessive weight gain was an independent risk factor for pouch failure with a hazard ratio of 1.69 (95% confidence interval = 1.01–2.84, P = 0.048) after adjusting for preoperative or postoperative use of anti-tumor necrosis factor biologics, postoperative use of immunosuppressants, Crohn's disease of the pouch, mechanical or surgical complications of the pouch, and postoperative pouch-associated hospitalization.

Conclusions: Excessive weight gain after closure of the ileostomy is associated with worse pouch outcomes in patients with inflammatory bowel disease. Appropriate weight control may help improve pouch retention.

© Crohn's & Colitis Foundation of America, Inc.

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