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Transmural Healing Evaluated by Bowel Sonography in Patients with Crohns Disease on Maintenance Treatment with Biologics

Castiglione, Fabiana MD; Testa, Anna MD; Rea, Matilde MD; De Palma, Giovanni Domenico MD; Diaferia, Maria MD; Musto, Dario MD; Sasso, Francesca MD; Caporaso, Nicola MD; Rispo, Antonio MD

doi: 10.1097/MIB.0b013e31829053ce
Original Clinical Articles

Background: Both thiopurines and anti-tumor necrosis factor (TNF) α agents are effective for treating Crohn’s disease (CD) as they can induce clinical remission (CR) and mucosal healing (MH) in most patients. Nevertheless, data on transmural healing (TH) induced by thiopurines and anti-TNF-α agents are still lacking. This study aimed to explore the rate of TH evaluated by bowel sonography in patients with CD treated with biologics and immunosuppressors and its correlation with CR and MH.

Methods: We performed an observational longitudinal study evaluating TH, CR, and MH in all patients with CD attending our clinic who would complete 2 years of maintenance treatment with biologics or thiopurines. CR and MH were assessed in accordance with current literature, whereas TH was recorded using bowel sonography. All patients underwent endoscopy and bowel sonography before starting treatment and 2 years later.

Results: The study included 66 patients with CD treated with biologics and 67 patients receiving thiopurines. Finally, TH was present in 17 patients on biologics and only 3 patients treated with thiopurines (25% versus 4%; P < 0.01; odds ratio = 6.2). CR was achieved in 37 patients on biologics and in 34 patients on thiopurines (59.7% versus 53%; P = not significant), whereas MH was more frequent in patients treated with anti-TNF-α agents even though without statistical significance (38% versus 25%; P = not significant).

Conclusions: TH can be achieved in approximately 25% of patients with CD treated with anti-TNF-α agents and significantly correlates with MH. Further studies are needed to define the potential role of TH as long-term prognostic factor.

Article first published online 3 July 2013

Department of Clinical Medicine and Surgery, University “Federico II” of Naples, Naples, Italy.

Reprints: Antonio Rispo, MD, Gastroenterologia, Università degli Studi di Napoli “Federico II”, Facoltà di Medicina e Chirurgia, Via S. Pansini 5, 80131, Naples, Italy (e-mail: antoniorispo@email.it).

The authors have no conflicts of interest to disclose.

Received February 13, 2013

Accepted March 4, 2013

© Crohn's & Colitis Foundation of America, Inc.
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