Skip Navigation LinksHome > April 2013 - Volume 19 - Issue 5 > Skin Side Effects of Inflammatory Bowel Disease Therapy
Inflammatory Bowel Diseases:
doi: 10.1097/MIB.0b013e3182802c07
Clinical Review Article

Skin Side Effects of Inflammatory Bowel Disease Therapy

Torres, Joana MD*; Buche, Sébastien MD; Delaporte, Emmanuel MD; Colombel, Jean-Frédéric MD, PhD

Collapse Box

Abstract

Abstract: Skin manifestations are common in patients suffering from inflammatory bowel disease (IBD) and can be associated with the disease itself, with nutritional deficiencies, or with therapy. All drugs currently used for treating IBD have the potential to cause dermatologic manifestations that can have a wide range of clinical presentations, from mild drug eruptions to potentially life-threatening immune-mediated reactions. The wider use of thiopurines and anti–tumor necrosis factor in the past years has led to the recognition of 2 more skin complications of IBD therapy: the potentially disfiguring non–melanoma skin cancer associated with the current or past use of thiopurines and the paradoxical new onset or exacerbation of anti–tumor necrosis factor-associated psoriasis. Despite being rare, these complications can be severe and lead to therapy discontinuation, and therefore, gastroenterologists need to become familiar with their epidemiology, diagnosis, and management. Herein, we reviewed the skin side effects of IBD therapy, specially focusing in thiopurines and anti–tumor necrosis factor therapy and in the recently described skin cancer and psoriasis, and we tried to advance some practical algorithms that can provide some help to the clinicians dealing with these complications in their day-by-day practice.

© Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.