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Neopterin Is a Novel Reliable Fecal Marker as Accurate as Calprotectin for Predicting Endoscopic Disease Activity in Patients with Inflammatory Bowel Diseases

Nancey, Stephane MD*,†; Boschetti, Gilles MD*,†; Moussata, Driffa MD*; Cotte, Eddy MD; Peyras, Julie PharmD§; Cuerq, Charlotte PhD§; Haybrard, Julie PharmD§; Charlois, Anne-Laure PharmD*; Mialon, Anne MD§; Chauvenet, Marion MD*; Stroeymeyt, Karine MD*; Kaiserlian, Dominique PhD; Drai, Jocelyne PhD§; Flourié, Bernard MD*,†

doi: 10.1097/MIB.0b013e3182807577
Original clinical Articles

Background: Fecal biomarkers have emerged as an important tool for assessing and monitoring disease activity in patients with inflammatory bowel diseases (IBDs). We performed a prospective head-to-head comparison of the diagnostic accuracy of both fecal calprotectin (fCal) and neopterin (fNeo), and serum C-reactive protein in predicting endoscopic disease severity in patients with IBD.

Methods: A total of 133 consecutive patients with IBD (78 Crohn's disease [CD] and 55 ulcerative colitis [UC]) undergoing a colonoscopy provided fecal samples for the measurement of fCal and fNeo concentrations and a blood sample for the serum C-reactive protein measurement. Endoscopic disease activities were scored independently according to the Simple Endoscopic Score for CD in patients with CD and to the Rachmilewitz Index in patients with UC. The respective performances of the fecal markers with respect to endoscopic disease severity were assessed by computing correlations, sensitivities, specificities, and overall accuracies at adjusted cutoffs and also test operating characteristics.

Results: The fCal and fNeo concentrations differed significantly in clinically and endoscopically active IBD when compared with those in patients with inactive disease. Both fCal and fNeo concentrations correlated closer with endoscopic scores in UC (r = 0.75 and r = 0.72, respectively; P < 0.0001 for both) than in CD (r = 0.53 and r = 0.47, respectively; P < 0.0001 for both). Using cutoffs of 250 μg/g for fCal and 200 pmol/g for fNeo, both fecal markers had similar overall accuracies to predict endoscopic activity in patients with CD (74%) and also a higher and similar accuracies (88% and 90%, respectively) in patients with UC, whereas accuracies of C-reactive protein were slightly lower in patients with CD and UC.

Conclusions: The fNeo is a novel reliable surrogate biomarker with the potential to identify patients with IBD with active mucosal lesions and represents an alternative marker as accurate as fCal to predict and monitor the severity of mucosal damages in patients with IBD.

Article first published online 18 March 2013

*Department of Gastroenterology, Hospices Civils de Lyon and University Claude Bernard Lyon 1, Pierre-Benite, France

INSERM U851, IFR 128 Biosciences Lyon-Gerland, Lyon, France

Department of Digestive Surgery

§Laboratory of Biochemistry, Lyon-Sud Hospital, Hospices Civils de Lyon and University Claude Bernard Lyon 1, Pierre-Benite, France

Reprints: Stéphane Nancey, MD, Department of Gastroenterology, Hospices Civils de Lyon, Lyon-Sud University Hospital, 69495 Pierre-Bénite, France (e-mail: stephane.nancey@chu-lyon.fr).

S. Nancey and G. Boschetti contributed equally.

The authors have no conflicts of interest to disclose.

Received August 01, 2012

Accepted August 02, 2012

© Crohn's & Colitis Foundation of America, Inc.
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