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Antibodies to mutated citrullinated vimentin and anti-cyclic citrullinated peptide antibodies in inflammatory bowel disease and related arthritis

Al-Jarallah, Khaled MD, FRCPC1,*; Shehab, Diaa MD, FRCPC1; Al-Attiyah, Rajaa MD, PhD2; Al-Azmi, Waleed MD, FRCPC1; Al-Fadli, Ahmad MD, FRCPC3; Zafar Haider, Mohammed MD, PhD4; Panaccione, Remo MD, FRCPC5; Ghosh, Subrata MD, FRCPC5

doi: 10.1002/ibd.21937
Original Article: Original Clinical Articles

Background: Antibodies that react with citrullinated proteins (anti-mutated citrullinated vimentin [anti-MCV] and second-generation anti-cyclic citrullinated peptide antibodies [anti-CCP2]) are markers for rheumatoid arthritis. Recent studies have demonstrated that these antibodies are present in other arthropathies including the spondyloarthritis, psoriatic arthritis, and juvenile idiopathic arthritis. Arthritis associated with inflammatory bowel disease (IBD) takes various forms, with some shared similarities with classic spondylarthropathies. Our objective was to investigate the role of anti-MCV and anti-CCP2 as potential biomarkers in IBD and related arthritis.

Methods: In all, 125 IBD patients (71 males, 54 females) were compared to 81 age- and sex-matched healthy controls. Anti-MCV and Anti-CCP2 IgG were measured using an enzyme linked immunosorbent assay.

Results: In the 125 IBD patients (mean age 32.6 ± 12.3 years), 44 (35.2%) had ulcerative colitis and 81 (64.8%) had Crohn's disease. Forty-four (35.2%) IBD patients developed arthritic manifestations. Antibody positivity was observed in 24/125 (19.2%) IBD patients and in 18/81 (22.2%) healthy subjects. The proportion of anti-MCV positivity among IBD patients and healthy individuals were similar: 16.8% vs. 16.0%, P = 0.887. Anti-CCP2 positivity among IBD patients and healthy individuals was also comparable: 6.4% vs. 6.2%, P = 0.948. Similarly, the presence of anti-MCV and anti-CCP2 antibodies was not different among IBD patients with and without arthritis. The mean titers of antibodies were low: anti-MCV (29.6 ± 7.5 U/mL) and anti-CCP2 (27.6 ± 4.0 U/mL) in IBD patients with arthritis.

Conclusions: Autoantibodies to citrullinated proteins were low in IBD-related arthritis. These findings suggest that these antibodies are not useful biomarkers in IBD to predict who may develop IBD-related arthropathy. (Inflamm Bowel Dis 2012)

1Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait

2Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait

3Department of Gastroenterology, Mubarak Al Kabeer Hospital, Safat, Kuwait

4Department of Pediatrics, Faculty of Medicine, Kuwait University, Safat, Kuwait

5Division of Medicine, Faculty of Medicine, University of Calgary, Alberta, Canada

*Reprints: Associate Professor, Kuwait University, Faculty of Medicine, Medicine Department, P.O. Box 24923, Safat 13110, Kuwait


Received 6 September 2011; Accepted 3 October 2011

Published online 23 November 2011 in Wiley Online Library (

Grant sponsor: Kuwait University Research Administration; Grant Number: MM 01/10.

© Crohn's & Colitis Foundation of America, Inc.
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