Inflammatory Bowel Diseases

Skip Navigation LinksHome > January 2012 - Volume 18 - Issue 1 > Inflammatory bowel disease‐associated thromboembolism: A sys...
Inflammatory Bowel Diseases:
doi: 10.1002/ibd.21307
Clinical Reviews

Inflammatory bowel disease‐associated thromboembolism: A systematic review of outcomes with anticoagulation versus catheter‐directed thrombolysis

Tabibian, James H. MD1,*; Streiff, Michael B. MD2

Collapse Box


Background:: Thromboembolism (TE) is a common extraintestinal complication of inflammatory bowel disease (IBD). Catheter‐directed thrombolysis (CDT) is being increasingly used to treat TE but often evokes fears of hemorrhagic complications (HCs) in patients with IBD. We reviewed clinical outcomes with anticoagulation (AC) and CDT in IBD patients with TE.

Methods:: Published cases of IBD patients with TE were identified by a PubMed search. Cases were divided into two groups based on treatment modality: AC alone or CDT. Pretreatment variables and treatment‐related outcomes were compared between treatment groups.

Results:: Fifty‐two cases of IBD‐associated TE were identified. Thirty‐five cases were treated with AC alone and 17 with CDT. There were no significant differences in pretreatment variables. Patients treated with CDT tended to be more likely to achieve complete or partial symptomatic (P = 0.02) and radiologic resolution (P = 0.06). Gastrointestinal (GI) and non‐GI HCs tended to occur more frequently with CDT, although these differences were not statistically significant (P = 0.44 and 0.15, respectively).

Conclusions:: CDT and AC both appear to be well tolerated by IBD patients with TE. CDT may be used preferentially in patients with life‐threatening TE, while AC may be preferable in patients with less clinically significant TE or patients at higher risk for bleeding. Further prospective studies are warranted to confirm these results and more definitively identify the best therapeutic approach for patients with IBD‐associated TE. (Inflamm Bowel Dis 2011;)

© Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.