Skip Navigation LinksHome > November 2011 - Volume 17 - Issue 11 > Mood and nonmood components of perceived stress and exacerba...
Inflammatory Bowel Diseases:
doi: 10.1002/ibd.21623
Original Article: Original Clinical Articles

Mood and nonmood components of perceived stress and exacerbation of Crohn's disease

Cámara, Rafael J.A. MD1; Schoepfer, Alain M. MD2; Pittet, Valérie PhD3; Begré, Stefan MD1; von Känel, Roland MD1,*; the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS) Group

Collapse Box

Abstract

Background:: Diverse psychological factors are involved in the pathophysiology of stress. In order to devise effective intervention strategies, it is important to elucidate which factors play the most important role in the association between psychological stress and exacerbation of Crohn's disease (CD). We hypothesized that the association between perceived stress and exacerbation of CD would remain after removal of mood and anxiety components, which are largely involved in stress perception.

Methods:: In all, 468 adults with CD were recruited and followed in different hospitals and private practices of Switzerland for 18 months. At inclusion, patients completed the Perceived Stress Questionnaire and anxiety and depression were assessed using the Hospital Anxiety and Depression Scale. During the follow‐up, gastroenterologists assessed whether patients presented with a CD exacerbation. By means of binary logistic regression analysis, we estimated the factor by which one standard deviation of perceived stress would increase the odds of exacerbation of CD with and without controlling for anxiety and depression.

Results:: The odds of exacerbation of CD increased by 1.85 times (95% confidence interval 1.43–2.40, P < 0.001) for 1 standard deviation of perceived stress. After removing the anxiety and depression components, the residuals of perceived stress were no longer associated with exacerbation of CD.

Conclusions:: The association between perceived stress and exacerbation of CD was fully attributable to the mood components, specifically anxiety and depression. Future interventional studies should evaluate the treatment of anxiety and depression as a strategy for potential prevention of CD exacerbations. (Inflamm Bowel Dis 2011;)

© Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.