Skip Navigation LinksHome > July 2011 - Volume 17 - Issue 7 > Self‐reported adherence to medical treatment prior to and du...
Inflammatory Bowel Diseases:
doi: 10.1002/ibd.21522
Original Clinical Articles

Self‐reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis

Julsgaard, Mette MD1*; Nørgaard, Mette MD, PhD2; Hvas, Christian Lodberg MD, PhD1; Buck, Daniel BScEE2; Christensen, Lisbet Ambrosius MD, DMSc1

Collapse Box

Abstract

Background: Adherence to medical treatment among women with ulcerative colitis (UC) prior to and during pregnancy has never been investigated. The aim was to examine predictors for and prevalence rates of nonadherence to maintenance treatment among women with UC prior to and during pregnancy.

Methods: We identified 115 women with UC having given birth during 2000‐2005 within a population of 1.6 million. They received a questionnaire about predictors and adherence and relapses were registered. We retrieved information on medical treatment from prescription databases and used logistic regression to estimate prevalence odds ratios (POR) for nonadherence by different predictors.

Results: Among 93 (81%) respondents, 63 (68%) reported taking medication, 53 of whom had filled prescriptions for relevant medication, yielding a positive predictive value of self‐reported use of medical treatment of 84.1% (95% confidence interval [CI] 72.7‐92.1). Approximately 60% reported adhering to medical treatment. Those who received counseling regarding medical treatment were less likely to be nonadherent compared with no counseling, especially during pregnancy (POR 0.2, 95% CI 0.04‐0.94). Of those who were nonadherent, fear of a negative effect on fertility/fetus was stated as the reason by 23% prior to and by 50% during pregnancy. Notably, 40.3% reported an episode of relapse during the pregnancy period, compared with 13.6% in the period 6 months prior to pregnancy.

Conclusions: Adherence was high despite fear of a negative effect on fertility or the fetus. Counseling predicted higher adherence. This may be important because our study suggests an increase in UC activity during pregnancy. (Inflamm Bowel Dis 2010)

© Crohn's & Colitis Foundation of America, Inc.

You currently do not have access to this article.

You may need to:

Note: If your society membership provides for full-access to this article, you may need to login on your society’s web site first.

Login

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.