At least 1 million new cases of nonmelanoma skin cancer (NMSC) are diagnosed in the United States each year and the incidence is increasing. A higher incidence of NMSC in organ transplant recipients on immunosuppression has been documented for some time, and recent studies indicate that patients with inflammatory bowel disease (IBD), particularly those treated with immunosuppressive medications, might also be at higher risk for this condition. In this review we summarize recent data evaluating the associations between immunomodulators, antitumor necrosis factor‐α biologic agents and NMSC in patients with IBD and other autoimmune conditions such as rheumatoid arthritis. We also offer recommendations for prevention of NMSC in these populations. (Inflamm Bowel Dis 2011;)
1 University of North Carolina‐Chapel Hill Department of Medicine, Division of Gastroenterology and Hepatology, Chapel Hill, North Carolina
2 University of North Carolina‐Chapel Hill Department of Pediatrics, Division of Gastroenterology and Hepatology, Chapel Hill, North Carolina
3 Duke University, Department of Dermatology, Durham, North Carolina
*Reprints: CB #7080, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599‐7080
Received 2 August 2010; Accepted 2 August 2010
Published online 4 November 2010 in Wiley Online Library (wileyonlinelibrary.com).
Supported, in part, by grants from the National Institutes of Health (NIH), grants T32 DK007634, 5‐KL2‐RR025746‐02, P30 DK034987, and a Cancer Development award from the Crohn's and Colitis Foundation of America.