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QuantiFERON TB gold testing for tuberculosis screening in an inflammatory bowel disease cohort in the United States

Qumseya, Bashar J. MD1; Ananthakrishnan, Ashwin N. MD, MPH2; Skaros, Sue PA-C2; Bonner, Michael MD1; Issa, Mazen MD2; Zadvornova, Yelena MD2; Naik, Amar MD2; Perera, Lilani MD2; Binion, David G. MD, AGAF3

doi: 10.1002/ibd.21329
Original Clinical Articles

Background: Reactivation of latent Mycobacterium tuberculosis (TB) is a rare, yet devastating infectious complication associated with anti-tumor necrosis factor alpha (TNF-α) therapy. We evaluated the performance of the QuantiFERON TB Gold test (QFT-G) for TB screening in a cohort of inflammatory bowel disease (IBD) patients in the United States.

Methods: We performed a retrospective, observational study of patients initiated and/or maintained on an anti-TNF-α agent in a single IBD referral center and recorded the frequency and the test results of QFT-G testing and the rate of TB reactivation.

Results: 512 QFT-G tests were done in 340 patients. Five patients (1.5%) had a positive, nine (2.7%) indeterminate, and 326 patients (95.8%) had a negative QFT-G. After a mean follow-up of 17 months there was one case of TB reactivation (0.3%). The use of immunosuppressive therapy or anti-TNF therapy at the time of testing did not affect the results of the QFT-G testing. Test–retest had substantial concordance (κ = 0.72). 25% of patients (n = 85) had TST testing. Concordance between the TST and QFT-G was found to be moderate (κ = 0.4152, P = 0.0041).

Conclusions: Most patients with negative QFT-G tolerated anti-TNF therapy with no evidence of TB reactivation. Concomitant use of immunosuppressive therapy or anti-TNF did not seem to affect QFT-G results. One patient had an indeterminate QFT-G while on infliximab and later developed miliary TB. Concordance with TST is moderate. (Inflamm Bowel Dis 2011;)

1Department of Medicine, Medical College of Wisconsin, Milwaukee, Wisconsin

2Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, Wisconsin

3Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Reprints: University of Pittsburgh School of Medicine, Scaife Hall Room 859, 3550 Terrace Ave., Pittsburgh, PA 15261


Received 18 March 2010; Accepted 22 March 2010

© Crohn's & Colitis Foundation of America, Inc.
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