Inflammatory Bowel Diseases

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Inflammatory Bowel Diseases:
doi: 10.1002/ibd.20991
Basic Science Review

Autophagy at the gut interface: Mucosal responses to stress and the consequences for inflammatory bowel diseases

Huett, Alan PhD1,2,*; Xavier, Ramnik J. MD1,2,3,*

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Abstract:: Autophagy is a conserved homeostatic process by which cells degrade and recycle cytoplasmic contents and organelles. Recently, autophagy has come to prominence as a factor in many disease states, including inflammatory bowel diseases. In this review we explore the recent discoveries in autophagy and how these relate to the special conditions experienced by the gut mucosa. We will pay particular attention to autophagy as an innate immune process and its role in the development and education of the adaptive immune system. (Inflamm Bowel Dis 2010;)

© Crohn's & Colitis Foundation of America, Inc.

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