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Impact of infliximab therapy after early endoscopic recurrence following ileocolonic resection of Crohn's disease: A prospective pilot study

Yamamoto, Takayuki MD, FACG1; Umegae, Satoru MD1; Matsumoto, Koichi MD1

Inflammatory Bowel Diseases:
doi: 10.1002/ibd.20915
Original Clinical Articles
Abstract

Background:: The efficacy of infliximab for endoscopic recurrence after resection of Crohn's disease (CD) has not yet been reported. The aim of this prospective study was to investigate the impact of infliximab on early endoscopic lesions after resection for CD.

Methods:: Twenty‐six patients maintaining clinical remission (CD activity index [CDAI] score <150) with mesalamine (3 g/day) after resection showed endoscopic recurrence in the neoterminal ileum at 6 months postoperatively (=baseline). Over the following 6 months, 10 patients were treated with continuous mesalamine (3 g/day), 8 patients were treated with azathioprine therapy (50 mg/day), and the other 8 patients were treated with infliximab therapy (5 mg/kg, every 8 weeks). During ileocolonoscopy at baseline and 6 months later, mucosal biopsies were taken for cytokine assays.

Results:: During 6‐month observation, no patients in the infliximab group, 3 (38%) in the azathioprine group, and 7 (70%) in the mesalamine group developed clinical recurrence (CDAI ≥150) (P = 0.01). At 6 months, endoscopic inflammation was improved in 75% of patients in the infliximab group, 38% in the azathioprine group, and 0% in the mesalamine group (P = 0.006). The mucosal interleukin (IL)‐1β, IL‐6, and tumor necrosis factor‐α levels significantly decreased in the infliximab group, while they significantly increased in the mesalamine group, and they did not change significantly in the azathioprine group.

Conclusions:: Infliximab therapy showed clear suppressive effects on clinical and endoscopic disease activity, and mucosal cytokine production in patients with early endoscopic lesions after resection. To confirm our conclusions, randomized controlled trials with a larger number of patients are necessary.

Author Information

1Inflammatory Bowel Disease Center & Department of Surgery, Yokkaichi Social Insurance Hospital, Yokkaichi, Mie, Japan

Reprints: Takayuki Yamamoto, MD, FACG, Inflammatory Bowel Disease Center & Department of Surgery, Yokkaichi Social Insurance Hospital, 10‐8 Hazuyamacho, Yokkaichi, Mie 510‐0016, Japan

E‐mail: nao‐taka@sannet.ne.jp

Received 7 January 2009; Accepted 29 January 2009

Published online in Wiley InterScience (www.interscience.wiley.com).

© Crohn's & Colitis Foundation of America, Inc.

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