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Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940–2000

Loftus, Conor G. MD1; Loftus, Edward V. Jr. MD1*; Harmsen, Scott W. MS2; Zinsmeister, Alan R. PhD2; Tremaine, William J. MD1; Melton, Joseph L. III MD3; Sandborn, William J. MD1

doi: 10.1002/ibd.20029
Original Clinical Articles: Update on CD and UC in Olmsted County, MN: Original Article

Background We previously reported that the prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in Olmsted County, Minnesota, had risen significantly between 1940 and 1993. We sought to update the incidence and prevalence of these conditions in our region through 2000.

Methods The Rochester Epidemiology Project allows population-based studies of disease in county residents. CD and UC were defined by previously used criteria. County residents newly diagnosed between 1990 and 2000 were identified as incidence cases, and persons with these conditions alive and residing in the county on January 1, 2001, were identified as prevalence cases. All rates were adjusted to 2000 US Census figures for whites.

Results In 1990–2000 the adjusted annual incidence rates for UC and CD were 8.8 cases per 100,000 (95% confidence interval [CI], 7.2–10.5) and 7.9 per 100,000 (95% CI, 6.3–9.5), respectively, not significantly different from rates observed in 1970–1979. On January 1, 2001, there were 220 residents with CD, for an adjusted prevalence of 174 per 100,000 (95% CI, 151–197), and 269 residents with UC, for an adjusted prevalence of 214 per 100,000 (95% CI, 188–240).

Conclusion Although incidence rates of CD and UC increased after 1940, they have remained stable over the past 30 years. Since 1991 the prevalence of UC decreased by 7%, and the prevalence of CD increased about 31%. Extrapolating these figures to US Census data, there were ≈1.1 million people with inflammatory bowel disease in the US in 2000.

(Inflamm Bowel Dis 2007)

1Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota

2Inflammatory Bowel Disease Clinic, Division of Biostatics, Mayo Clinic College of Medicine, Rochester, Minnesota

3Inflammatory Bowel Disease Clinic, Division of Epidemiology, Mayo Clinic College of Medicine, Rochester, Minnesota

*Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905

E-mail: loftus.edward@mayo.edu

Received for publication 11 September 2006; Accepted 18 September 2006

Published online 19 December 2006 in Wiley InterScience (www.interscience.wiley.com).

Grant sponsor: Mayo Foundation for Medical Education and Research; Grant sponsor: National Institutes of Health; Grant Number: AR30582.

Presented in part at the 104th Annual Meeting of the American Gastroenterological Association, Orlando, Florida, May 17–22, 2003 (Gastroenterology 2003;124(4 Suppl 1):A36.)

© Crohn's & Colitis Foundation of America, Inc.
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