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The Pathogenicity of Cytomegalovirus in Inflammatory Bowel Disease: A Systematic Review and Evidence-based Recommendations for Future Research

Hommes, Daniël W. MD, PhD*; Sterringa, Gerben MD*; van Deventer, Sander J. H. MD, PhD*; Tytgat, Guido N. J. MD, PhD*; Weel, Jan MD†

Inflammatory Bowel Diseases:
Original Contributions

During recent years, a clear association between complicated courses of ulcerative colitis and the presence of cytomegalovirus (CMV) has been established. The exact pathogenic role of CMV in these patients remains unclear despite a great number of published reports. Therefore, we undertook a systematic review to appraise critically all available evidence ìn the literature on the role of CMV during inflammatory bowel disease. We identified and analyzed more than 30 case reports and 9 case series. Based on these results, we propose a model for viral replication during inflammation and provide recommendations for future research.

Author Information

From the Departments of *Gastroenterology and Hepatology and †Clinical Virology, Academic Medical Centre, Amsterdam, The Netherlands.

Received for publication March 10, 2003; accepted August 25, 2003.

Reprints: Dr. D. W. Hommes, Department of Gastroenterology and Hepatology, Academic Medical Centre, C2-116, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands (e-mail:

© Crohn's & Colitis Foundation of America, Inc.

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