Skip Navigation LinksHome > March 2013 - Volume 3 - Issue 1 > Penile intraepithelial neoplasia: management and outcomes
Human Andrology:
doi: 10.1097/01.XHA.0000423421.22785.86
Original articles

Penile intraepithelial neoplasia: management and outcomes

Zreik, Abdullah; Ismail, Mohammed; Nigam, Raj

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Background: Penile cancer is a rare malignancy that affects 1 in 100 000 men. Penile intraepithelial neoplasia (PeIN) is a premalignant lesion that can affect any part of the penile surface. PeIN shows different degrees of dysplasia and is therefore classified into PeIN 1, 2, and 3. PeIN 3 is also known as carcinoma in situ. PeIN is believed to have a close association with human papilloma virus infection. Treatment of PeIN can potentially prevent progression to penile cancer. This study aimed to report on the management and follow-up outcomes for patients diagnosed with PeIN.

Materials and methods: A total of 38 consecutive patients diagnosed with PeIN 3 were included in this review. Our institutional Penile Cancer database was used for data collection. We report on the demographics, risk factors, surgical management, recurrence rates, and follow-up outcomes.

Results: The median age of the patients was 63 years (range 24–86). Risk factors were present in 81.5% of patients. 81.6% of the patients had received surgical treatment with radical circumcision, wide local excision, and glans resurfacing. Topical treatment with 5-fluorouracil or imiquimod was used in 18.4% of patients. Five patients had recurrence of PeIN 3 and required further treatment. After a mean follow-up of 69 months (range 8–298), the cancer-free rate was 100%.

Conclusion: Surgical treatment of PeIN 3 leads to excellent outcomes and frequent follow-up is required.

© 2013 Human Andrology


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