Constipation may be the result of systemic disorders or drugs or may be idiopathic. There are two types of idiopathic constipation—normal and slow transit chronic constipation and functional pelvic floor dysfunction. Causes may be psychological factors, physical medical problems, or medications (Table 2). Those considered at increased risk for constipation are more likely to be female (three times more likely than men); they have lower socioeconomic and education levels, and there is an increase in frequency after age 65, especially in those taking five or more medications (McCrea et al., 2009). Also, scores for depression and anxiety are significantly higher in patients with functional constipation (Zhou et al., 2010) but may be due to frequently prescribed medications for treatment.
Chronic constipation is considered a symptom with varying intensity and presence, and may be subjective in nature. The term constipation has varied meanings for different people because the regularity of bowel movements varies among individuals. Therefore, diagnosis of constipation should not be based solely on the perception of the patient. Common associated complaints are anorexia, nausea and vomiting, bloating, and abdominal pain. In addition, if left untreated, hemorrhoids, fissures, tears, and rectal prolapse may occur.
Although usually temporary, constipation is caused by the colon absorbing too much water as a result of decreased motility of the large intestine. This may be due to fatigue and weakness, or pain, which eventually causes the loss of abdominal wall muscle tone, and decreased intra-abdominal pressure necessary to defecate, so relaxation of the external anal sphincter is necessary. Consistent voluntary suppression of the urge to empty the bowel is another cause of constipation (Leung et al., 2011).
Definition of Constipation
To define and standardize constipation, the Rome III Criteria was revised in 2006 by the American Gastroenterological Association (Longstreth et al., 2006). Although this is an established criterion, comparison with the history of the individual should be considered. For example, in some persons, a lifetime of less than 3 stools per week may be normal. In addition, assessment of stool type may be just as important as number of stools reported. A person is considered to be constipated if there are at least two of the following symptoms reported for at least 3 months with symptom onset at least 6 months prior to diagnosis:
- less than three stools per week,
- straining with at least 25% of stools,
- lumpy, hard stool at least 25% of the time,
- feeling of incomplete evacuation or sensation of blockage for at least 25% of stools,
- need to manually remove stool at least 25% of the time,
- loose stools are rarely present without the use of laxatives, or
- lack of sufficient criteria for irritable bowel syndrome.
Constipation with a weight loss of greater than 10 lb, family history of colon cancer, iron deficiency anemia, positive fecal occult blood testing, rectal bleeding, and acute onset in the elderly are considered “alarm symptoms” and may indicate a more serious condition, possibly cancer, and needs to be evaluated by the primary care provider (Gallefos-Orozco et al., 2012).
Detailed assessment includes in-depth questioning regarding: frequency, pain on defecation, straining, and stool characteristics. Difficulty in evacuating the rectum or feeling of bowel fullness and discomfort requires investigation and may indicate functional pelvic floor dysfunction. Also, lifestyle, diet, medication history, and assessment of laxative use are important (Leung et al., 2011).
Digital rectal exam may be necessary to assess for impaction and should be considered with caution in immunocompromised individuals due to increased risk of infection and bleeding. Diagnostic tests are not routinely recommended; however, labs for hypercalcemia, hypokalemia, and hypothyroidism may be considered, as these are risk factors for constipation (Jashed et al., 2011).
Prevention and Management
The aim of management of constipation should be comfortable passage of stool with a feeling of complete evacuation. Use of a daily stool diary may be helpful, as frequency of bowel movements is usually underestimated. An example of a stool diary is found at http://www.bowelcontrol.nih.gov/stool_diary_508.pdf. In addition to recording bowel movements, stool characteristics and associated abdominal discomfort may be helpful to determine the type of constipation and appropriate treatment options. An example of the Bristol Stool Form scale may be found at http://www.bowelcontrol.nih.gov/Bristol.aspx. Treatment should be customized for each individual.
An extremely effective method to prevent constipation is to eliminate medications that induce constipation. Careful assessment of the current medications the patient is taking need to be considered including over-the-counter, herbal, and other self-medicating regimens. It is thought that more than 100 commonly prescribed medications cause constipation in more than 3% of the patients taking them.
Fiber and Dietary Considerations
Fiber may be helpful in patients with normal or slow transit constipation, in those patients found to have constipation caused by fiber deficiency (Leung et al., 2011). Foods high in fiber include cereal fiber, which works by resisting digestion and retaining water. Fiber in citrus fruits and legumes stimulate the growth of colonic bacteria, which increases stool mass. Wheat bran is one of the more effective fibers, but may increase bloating and abdominal pain, which may lead to poor compliance. Fiber at 20 to 35 g/day is recommended, unless the person is debilitated, it is difficult to maintain hydration, or if bowel obstruction is suspected (Box 2). Bran was found in two controlled trials to reduce use of laxatives in a geriatric population (Sturtzel & Elmadfa, 2008; Sturtzel et al., 2009). Prunes were found to be effective in one trial with improved stool consistency (Box 3) (Attulauri et al., 2011). One example that combines prunes with bran is “Power Pudding” (Box 4).
Postmeal colonic motility is highest in the morning, so encourage patients to set aside time after the morning meal to defecate. Avoiding foods known to cause constipation may be helpful; these are ice cream, cheese, meat, and processed food.
There is no evidence that constipation can successfully be treated solely by increasing fluid intake unless the person is dehydrated. The recommendation for increasing fluids, especially in the elderly, has remained mostly out of tradition (Box 5). However, fluid combined with fiber has been demonstrated in at least one study, to improve constipation (Anti et al., 1998).
Nursing practice is based on the opinion of experts regarding the need to encourage physical activity to avoid constipation (Box 6). However, this practice has not been demonstrated with consistent evidence-based practice. In fact, two randomized controlled trials found no benefit from exercise in institutionalized elderly patients to improve constipation (Chin et al., 2006; Simmons & Schnelle, 2004).
Fiber, Increasing Hydration, and Exercise
There are many strongly held beliefs about constipation that are not evidence-based regarding these three factors—fiber, hydration, and exercise. Although frequently recommended, increasing dietary fiber with the exception of bran, fluid intake, and daily exercise to avoid constipation has not been substantiated in research studies, with Level 2C evidence at best (Leung et al., 2011). This rating is based on the Strength of Recommendations Taxonomy (SORT) (Box 7) (Ebell et al., 2004).
Case Study Conclusion
One of the most common symptoms in advanced disease is constipation. Cancer in older adults present significant challenges in palliative care, and care needs to be taken to find the right combination of medications that control pain, but minimize sedation, confusion, and constipation. The most frequent nonobstructive cause of constipation in older adults, especially at the end of life is medications (Rao & Go, 2010). In the case study presented, Mrs. P is taking several medications that can cause constipation including verapamil, amitriptyline, ferrous sulfate, and opioid pain medication. Following consultation with the team pharmacist, dietitian, and hospice physician, her verapamil was switched to a β-blocker for rate control of her atrial fibrillation; amitriptyline was changed to a selective serotonin reuptake inhibitor to help manage her depression, and ferrous sulfate was discontinued, as her lab values (H/H) were within normal limits. A bowel regimen was initiated as well for Mrs. P to prevent opioid-induced constipation with “power pudding” 2 tablespoons with each meal, and assistance to the restroom following breakfast and lunch meals. Fecal impactions were eliminated, and her fatigue and depression improved.
Nursing Implications for End-of-Life Care
Home healthcare nurses are in the best position to identify and alleviate constipation at the end of life, which is typical for these patients, and a significant impediment to achieving the goal of providing comfort. It is essential to determine if the person is, in fact, constipated. Much of the current recommendations for nonpharmacologic interventions may be based primarily on myths handed down from one generation to the next. Fiber with the exception of bran, increased fluids, and exercise, has limited evidence-based research support. Using a team approach, prevention of constipation may require careful consideration of underlying causes and medication management, including pharmacological interventions with over-the-counter or prescription medications to be started sooner rather than later.
Further research is needed. Well-designed prospective randomized trials evaluating the risks and benefits of hydration, diet, exercise, and physical activity on constipation are recommended for future research, as there is minimal or conflicting evidence.
Anti, M., Pignataro, G., Armuzzi, A., Valenti, A., Lascone, E., Marmo, R., ..., Gasbarrini, G. (1998). Water supplementation enhances the effect of high fiber diet on stool frequency and laxative consumption in adult patients with functional constipation. Hepatogastroenterology
Attulauri, A., Donahoe, R., Valestin, J., Brown, K., & Rao, S. (2011). Randomized clinical trial: Dried plums (prunes) versus psyllium for constipation. Alimentary Pharmacology and Therapeutics, 33
Chin, A., Paw, M. J., van Poppel, M. N., & van Meehelen, W. (2006). Effects of resistance and functional skills training on habitual activity and constipation among older adults living in long-term care facilities: A randomized controlled trial. BMC Geriatrics, 6
Ebell, M. H., Siwek, J., Weiss, B. D., Woolf, S. H., Susman, J., Ewigman, B., & Bowman, M. (2004). Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature. Journal of the American Board of Family Practice, 17
Gallefos-Orozco, J. F., Foxx-Orenstein, A. E., Sterler, S. M., & Stoa, J. M. (2012). Chronic constipation in the elderly. American Journal of Gastroenterology, 107
Higgins, P. D., & Johanson, J. F. (2004). Epidemiology of constipation in North America: A systemic review. American Journal of Gastroenterology, 99
Jashed, N., Lee, Z. E., & Olden, K. W. (2011). Diagnostic approach to chronic constipation in adults. American Family Physician, 84
Leung, L., Riutta, T., Kotecha, J., & Rosser, W. (2011). Chronic constipation: An evidence-based review. Journal of the American Board of Family Medicine, 24
Lindeman, R. D., Romero, L. J., Liang, H. C., Baumgartner, R. N., Koehler, K. M., & Garry, P. J. (2000). Do elderly persons need to be encouraged to drink more fluid? Journal of Gerontology Series A Biological Sciences and Medical Sciences, 55
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006). Functional bowel disorders. Gastroenterology, 130
McCrea, G. L., Miaskowski, C., Stotts, N. A., Macera, L., & Varma, M. G. (2009). A literature review on gender and age differences in the prevalence and characteristics of constipation in North America. Journal of Pain and Symptom Management, 37
Rao, S., & Go, J. (2010). Update on the management of constipation in the elderly: New treatment options. Clinical Interventions in Aging, 5
Simmons, S. F., & Schnelle, J. F. (2004). Effects of an exercise and scheduled-toileting intervention on appetite and constipation in nursing home residents. Journal of Nutrition, Health, and Aging, 8
Singh, G., Lingala, V., Wang, H., Vadhavkar, S., Kahler, K., Mithal, A., & Triadafilopoulos, G. (2007). Use of health resources and cost of care for adults with constipation. Clinical Gastroenterology and Hepatology, 5
Sturtzel, B., & Elmadfa, I. (2008). Intervention with dietary fiber to treat constipation and reduce laxative use in residents of nursing homes. Annals of Nutrition and Metabolism
(Suppl 1), 54–56.
Sturtzel, B., Mikulits, C., Gisinger, C., & Elmadfa, I. (2009). Use of fiber instead of laxative treatment in a geriatric hospital to improve the wellbeing of seniors. Journal of Nutrition, Health and Aging, 13
Sun, S. X., DiBonaventura, M., Purayidathil, F. W., Wagner, J. S., Dabbous, O., & Mody, R. (2011). Impact of chronic constipation on health related quality of life, work productivity and healthcare use: An analysis of the National Health and Wellness survey. Digestive Diseases and Sciences, 56
© 2012 Lippincott Williams & Wilkins, Inc.
Zhou, L., Lin, Z., Lin, L., Wang, M., & Zhang, H. (2010). Functional constipation: Implications for nursing interventions. Journal of Clinical Nursing, 19