The aim of this study was to determine the predictors of health risk behaviors of adolescents. A cross-sectional and descriptive design was used. A convenience sample of 436 undergraduate students was recruited from departments and faculties of Atatürk University. The researcher visited university departments 5 working days each week to conduct interviews with the students. The students were asked to complete a questionnaire in their classrooms. The data analysis used multivariate testing to identify predictors of health risk behaviors. The mean score on the health risk behavior scale indicated that the participants sometimes engaged in risky behaviors concerning diet, anger, stress, and disease prevention. The adolescents frequently engaged in risky behavior concerning medical compliance and beliefs about masculinity. Demographically, age, gender, income, and education level of demographic characteristics of the adolescents and, in terms of health status, health behaviors and the experience of a serious disease were significant predictors of adolescent health risk behaviors. In this study, some demographic characteristics were predictors for health risk behaviors, in general, of adolescents.