Nowadays burnout is a common issue in all health systems and therapeutic professions. Burnout is caused by job stressors and results in reduction in output, increase in absenteeism and health expenses, behavioral changes, and sometimes drugs abuse. Nonetheless, people who have hardy personalities experience less exhaustion. The present research aimed to present a causal model of antecedents with burnout to emphasize the intermediate role of hardy personality in the nurses working in the public hospitals of Shiraz, Iran. The study data were collected using the Nursing Burnout Scale questionnaire (Int J Nurs Stud. 2008;45(3):418-427). In addition, the structural equation method was used as a model in order to determine the relationship between the variables. The suggested pattern in this research was checked by Leasrel software, version 8.5. The study results showed that antecedents, such as incorrect supervision, responsibility, and workload, have a significant effect on burnout. However, mediated hardy personality had no effect on burnout. The results also showed that the people who had hardy personality could manage the stressful situations well and, consequently, rarely experience burnout. Overall, if the job stressors are existent in the job environment and the individuals cannot eradicate them, they will cause burnout outbreak.