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Eighth Warren K. Sinclair Keynote Address: Heavy Ions in Therapy and Space: Benefits and Risks

Durante, Marco*

doi: 10.1097/HP.0b013e318264b4b6
Warren K. Sinclair Keynote Address

Abstract: Heavy charged particles produce biological damage that is different from that normally produced by sparsely ionizing radiation, such as x- or gamma-rays, which are a large component of the natural radiation background. In fact, as a result of the different spatial distribution of the energy deposited along the core and penumbra of the track, DNA lesions are exquisitely complex and difficult to repair. Relative biological effectiveness (RBE) factors are normally used to scale from x-rays to heavy ion damage, but it should be kept in mind that RBE depends on several factors (dose, dose rate, endpoint, particle energy, and charge, etc.), and sometimes heavy ions produce special damages that just cannot be scaled by x-ray damage alone. These special characteristics of heavy ions can be used to treat tumors efficiently, as it is currently done in Japan and Germany, but they represent a threat for human space exploration.

*GSI Helmholtz Center for Heavy Ion Research and Darmstadt University of Technology, Planckstrasse 1, 64291 Darmstadt, Germany.

The author declares no conflict of interest.

For correspondence contact the author at GSI Helmholtz Center for Heavy Ion Research and Darmstadt University of Technology, Planckstrasse 1, 64291 Darmstadt, Germany, or email at m.durante@gsi.de.

(Manuscript accepted 14 June 2012)

©2012Health Physics Society