This issue of JHTR features manuscripts addressing a variety of issues and sub-populations: Amantadine for irritability, menstrual phase and outcome, pre-injury coping style and post-injury quality of life, tinnitus and sexual functioning and fatigue, to name a few. For researchers there are articles on use of the Glasgow Coma Scale as well as a primer on issues confronted when analyzing dichotomous variables in longitudinal studies. Not to be missed is an article using an approach to comparative effectiveness research that has attracted some controversy––the article, a commentary and a response are included in this issue.
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