Silver, et al. Antiphospholipid antibodies in stillbirth
Why should you read about this topic?
Explaining causes of stillbirth opens the door to effective prevention.
What were the authors trying to do?
Compare the prevalence of antiphospholipid antibodies in deliveries with and without stillbirth
Who participated and in what setting?
Women (stillbirth N=582; live birth N=1547) enrolled at delivery in the Stillbirth Collaborative Research Network between 2006-8
What was the study design?
Multi-center, population-based case-control
What were the main outcome measures?
Maternal serum anticardiolipin antibodies (IgG and IgM) and anti-β2-glycoprotein-I antibodies (IgG and IgM)
What were the results?
Stillbirth was associated with three-fold increased odds of elevated levels of anticardiolipin and anti-β2-glycoprotein-I IgG antibodies
What is the most interesting image in the paper?
What were the study strengths and weaknesses?
Strengths: population-based; large number of stillbirths; diverse population; extensive evaluation for causes of stillbirth. Weaknesses: no follow-up antibody testing; no lupus anticoagulant testing
What does the study contribute for your practice?
In cases of unexplained stillbirth, check for maternal antiphospholipid antibodies