Win et al. Family history and risk of endometrial cancer: a systematic review and meta-analysis
Why should you read about this topic?
Endometrial cancer is the most common gynecologic cancer in developed countries.
What were the authors trying to do?
Estimate the risk of endometrial cancer for women with a family history of cancer.
Who participated and in what setting?
Cases (N=37,381) and controls in 16 previously published case-control or cohort studies
What was the study design?
Systematic review and meta-analysis
What were the main outcome measures?
Relative risk for endometrial cancer
What were the results?
Relative risk for endometrial cancer in women with a first degree relative with endometrial cancer was 1.82 (95% CI 1.65, 1.98). Relative risk for endometrial cancer with a first degree relative with colorectal cancer was 1.17 (95% CI 1.03, 1.31). Women with a first degree relative with breast, ovarian, and cervical cancer had no increased risk.
What is the most interesting image in the paper?
What were the study strengths and weaknesses?
Strengths: stratified analyses and linear meta-regression modeling showed that the risk estimates are robust. Weaknesses: most of the studies used unverified diagnoses of cancer in relatives; exposure limited to first-degree relatives.
What does the study contribute for your practice?
Women with a first-degree relative with endometrial or colorectal cancer have an increased risk of endometrial cancer