OBJECTIVE: To compare the risk of subsequent oophorectomy among women who underwent hysterectomy for benign indications and those who did not.
METHODS: Using Rochester Epidemiology Project resources, we compared the risk of oophorectomy through December 31, 2008, among 4,931 women in Olmsted County, Minnesota, who underwent ovary-sparing hysterectomy for benign indications (case group) between 1965 and 2002, with 4,931 age-matched women who did not undergo hysterectomy (referent group). The cumulative incidence of subsequent oophorectomy was estimated by the Kaplan-Meier method, and comparisons were evaluated by Cox proportional hazard models using age as the time scale to allow for complete age adjustment.
RESULTS: The median follow-up times for case group and referent group participants were 19.6 and 19.4 years, respectively. At 10, 20, and 30 years after hysterectomy, the respective cumulative incidences of subsequent oophorectomy were 3.5%, 6.2%, and 9.2% among case group participants and 1.9%, 4.8%, and 7.3% among referent group participants. The overall risk of subsequent oophorectomy among case group participants was significantly higher than among referent group participants (hazard ratio [HR] 1.20, 95% confidence interval [CI] 1.02–1.42; P=.03). Furthermore, among case group participants, the risk of subsequent oophorectomy was significantly higher (HR 2.15, 95% CI 1.51–3.07; P<.001) in women who had both ovaries preserved compared with those who initially had one ovary preserved.
CONCLUSION: The incidence of oophorectomy after hysterectomy is only 9.2% at 30-year follow-up and is only 1.9 percentage points higher than the incidence of oophorectomy in referent women with intact reproductive organs.
LEVEL OF EVIDENCE: II
Thirty years after hysterectomy for benign indications, the cumulative incidence of oophorectomy is low (9.2%), but it is higher than the incidence among women with intact uteri.
Division of Obstetrics and Gynecology, University of Texas Health Science Center, San Antonio, Texas; and the Divisions of Gynecologic Surgery, Gastroenterology and Hepatology, Biomedical Statistics and Informatics, and Epidemiology, Mayo Clinic, Rochester, Minnesota.
Corresponding author: John Gebhart, MD, MS, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55905; e-mail: email@example.com.
Supported in part by grant DK 78924, and made possible by the Rochester Epidemiology Project (AG 034676 from the National Institute on Aging), United States Public Health Service.
Financial Disclosure The authors did not report any potential conflicts of interest.
Presented in abstract form at the 37th Annual Society for Gynecologic Surgeons Meeting, April 11-13, 2011, San Antonio, Texas.
The authors thank Shunaha Kim-Fine, MD, for assistance in data collection. Editing, proofreading, and reference verification were provided by the Section of Scientific Publications, Mayo Clinic.
Ovarian cancer causes 14,000 deaths annually in the United States.1 Performing blood-based screening tests or ultrasonographic surveillance has failed to improve early detection or survival. Prophylactic oophorectomy at the time of benign hysterectomy prevents subsequent ovarian malignancy. However, in those at low risk for ovarian malignancy, the absolute risk of ovarian cancer among women after ovarian preservation during benign hysterectomy is low (0.03–1.96%).2,3 A 24-year follow-up of the Nurses' Health Study revealed that only 34 of 13,035 women (0.3%) who had ovarian preservation at the time of hysterectomy later died of ovarian cancer.4 Furthermore, a growing body of evidence suggests that prophylactic oophorectomy is associated with increased overall mortality, coronary heart disease, dementia, osteoporosis, and other cancer mortality.4–7
Women with ovarian preservation are at risk for future oophorectomy.8 This risk ranged from 2.9% to 7.7% in previous studies.5,9,10 However, this information was derived from studies with short follow-up that were not population-based and lacked a comparison group.10–12 Moreover, in some series, subsequent oophorectomy was prompted by additional screening tests (eg, pelvic ultrasonography) and thus may not reflect the true natural history of disease. An accurate appraisal of this question is necessary to refine our understanding of the risk-to-benefit ratio of prophylactic oophorectomy. We compared the risk of oophorectomy in a large community cohort of women who had hysterectomy for benign indications with age-matched referent women with intact uteri. In addition, the risk of pelvic reoperation was compared in women with one ovary compared with both ovaries preserved during hysterectomy.
MATERIALS AND METHODS
This study used the data resources of the Rochester Epidemiology Project, which links and indexes the medical records of virtually all medical providers who serve the population of Olmsted County, Minnesota, including Mayo Clinic and its affiliated hospitals (Rochester Methodist and Saint Marys), and the Olmsted Medical Center and its affiliated community hospital.13 Because these institutions provide nearly all medical care for the community, this resource results in a comprehensive source of both inpatient and outpatient information for population-based epidemiologic research.14 The Rochester Epidemiology Project captures information for virtually all individuals who have lived in Olmsted Country from 1966 onward. As of July 2009, the Rochester Epidemiology Project included information for 493,606 individuals and their respective medical records from 65 different health care providers.15 The majority of Olmsted County residents use the medical system, including 85% of women of all ages examined in the past 3 years and more than 90% of adults older than 70 years examined in the past year.16 According to statistics from 2000, the majority of Olmsted County residents are white (90.3%), which is similar to the remainder of Minnesota (89.4%) and higher than in the United States overall (75.1%). In 2000, Olmsted County had a 2.7% black population and 2.4% Hispanic population.17
After approval by the Institutional Review Boards of both Mayo Clinic and Olmsted Medical Center, Rochester Epidemiology Project resources were used to identify all Olmsted County residents who underwent hysterectomy between January 1, 1965 and December 31, 2002.18 The procedure type and indications were identified electronically, as were the route of hysterectomy, unilateral or bilateral ovarian preservation, the date of subsequent oophorectomy, and the date of last follow-up or death.18 As had been performed previously, we randomly selected 100 women and manually compared the procedure type in the electronic medical record system with the procedure type listed in the surgical note; these two sources agreed in 83% of cases.
Of the 9,893 women with hysterectomy in this original cohort, 876 women (8.8%) who had not authorized the use of their medical records for research were excluded.19 We also excluded 914 women who had hysterectomy for malignant disease and 3,172 women who had no intact ovaries at the completion of their hysterectomy. The remaining 4,931 women (case group) were included for further analysis. For each hysterectomy case, one matched woman (referent group) was randomly selected from all Olmsted County female residents born within 1 year of a case group participant and who had been examined at Mayo Clinic or Olmsted Medical Center in the same year that her matched case group participant underwent hysterectomy (index date). As of the index date, the referent group participant had not undergone hysterectomy and had at least one intact ovary. For each case participant and referent participant, the date of subsequent oophorectomy and date of last follow-up or death before December 31, 2008, were obtained electronically. For each referent group participant, the date of subsequent hysterectomy before December 31, 2008, also was obtained.
Analysis was performed using the Statistical Analysis System. The Kaplan-Meier method was used to estimate the cumulative incidence of oophorectomy (1 minus the probability of survival free of oophorectomy) after the index date. The duration of follow-up was calculated from the index date to the date of the subsequent oophorectomy; otherwise, the follow-up was censored at the date of last follow-up. The influence of hysterectomy (case compared with referent) on the risk of subsequent oophorectomy was evaluated based on fitting a Cox proportional hazards model using age as the time scale to allow for complete age adjustment. The association was summarized by calculating the hazard ratio (HR) and 95% confidence interval (CI) using the model-estimated coefficient and its standard error estimated by the model. As a secondary analysis, the follow-up for a referent woman was censored at the date of a subsequent hysterectomy if the hysterectomy preceded an oophorectomy or their last follow-up date.
Among the case group participants, influence of age and calendar year on the risk of subsequent oophorectomy was assessed on the basis of fitting standard Cox models using time since hysterectomy as the time scale. The HR for the association between ovarian preservation (unilateral compared with bilateral) and risk of subsequent oophorectomy was estimated from a Cox model, again using age as the time scale to allow for complete age adjustment.
Our power calculations were completed based on reviewing past work with a similar cohort. We assumed that approximately 4,500 women would undergo hysterectomy with preservation of one or both ovaries. Because the reported frequency of reoperation after preservation of one or both ovaries during hysterectomy ranges from 3% to 7.6%,12 we anticipated that between 135 and 342 case group participants would have subsequent oophorectomy. Based on a sample size of 4,500 hysterectomy case group participants and 4,500 age-matched referents, the study was predetermined to have 80% power to detect HR more than 1.5 if a total of 200 women had subsequent oophorectomy, using sample size and power calculations for the two-sided log-rank test (with a type I error level of 5%), as proposed by Schoenfeld.20
Within this cohort of 4,931 hysterectomy case group participants and 4,931 age-matched referent group participants, both ovaries were intact at the index date in 79.5% of case group participants and 98.3% of referent group participants. The mean age at the index date was 42.9 years (standard deviation [SD] 11.7 years) in case group participants and 43.6 years (SD 12.1 years) in age-matched referent group participants (Table 1). Approximately 74% of case group participants had vaginal hysterectomy; myomatous uterus was the most common indication for surgery (29.5%). Among the hysterectomy case group participants, the median duration of follow-up was 19.6 years (interquartile range 9.6–29.0 years, range less than 0.1–43.5 years), during which time 315 women underwent oophorectomy. The referents had a median follow-up of 19.4 years (interquartile range 9.7–28.9 years, range less than 0.1–43.5 years), during which time 247 women had oophorectomy (89 oophorectomy only and 158 oophorectomy concurrent with hysterectomy). The cumulative incidence of subsequent oophorectomy was 3.5%, 6.2%, and 9.2%, respectively, among the case group participants and 1.9%, 4.8%, and 7.3%, respectively, among the referent group participants at 10, 20, and 30 years after the index date (Fig. 1). The overall risk of subsequent oophorectomy among the case group participants was higher than that in the referent group participants (HR 1.20, 95% CI 1.02–1.42; P=.03). In a secondary analysis, the follow-up for a referent woman was censored at the date of a subsequent hysterectomy. The result of the secondary analysis was similar to the primary analysis (HR 1.22, 95% CI 1.03–1.45; P=.02).
Among the case group participants, age at the time of hysterectomy was associated with the risk of subsequent oophorectomy (HR 1.62 per 10-year increase in age, 95% CI 1.50–1.75; P<.001). The risk of subsequent oophorectomy also was related to the calendar period when hysterectomy was performed; in other words, it was higher (HR 1.35, 95% CI 1.26–1.45 per 5-year increase in the calendar year; P<.001) for women who underwent hysterectomy more recently.
Either one ovary (1,015 women; mean age 40.7 years, SD 10.1 years) or both ovaries (3,916 women; mean age 43.5 years, SD 12 years) were preserved at hysterectomy. Among women with one preserved ovary, the cumulative incidence of subsequent oophorectomy was 1.2% at 2 years, 2.8% at 10 years, and 4.0% at both 20 and 30 years (Table 2). Among women with both ovaries intact, the cumulative incidence was 0.7% at 2 years, 3.7% at 10 years, 6.8% at 20 years, and 10.6% at 30 years. Hence, women in whom both ovaries were preserved at hysterectomy had an increased risk of reoperation (HR 2.15, 95% CI 1.51-3.07; P<.001) relative to women who did not have both preserved (ie, had only one ovary preserved).
Although the cumulative incidence of a subsequent oophorectomy was higher among the case group (3.5%, 6.2%, and 9.2%) than in the referent group (1.9%, 4.8%, and 7.3%) at 10, 20, and 30 years, respectively, the absolute risk showed a minimal difference (less than 2 percentage points at 20-year follow-up and 30-year follow-up). Moreover, the cumulative incidence of reoperation if both ovaries were preserved was only 10.6% at 30-year follow-up. Our estimates of reoperation at 30 years are higher than the previously reported range of 2.9% to 7.7%.10–12 However, these studies had a shorter follow-up period (average duration of 4 years) and lacked a comparison group.
We theorize that disruption of ovarian blood flow as a result of hysterectomy may alter ovarian function, which could lead to adnexal pathology. In fact, menopause has been shown to occur earlier in premenopausal women who have undergone ovary-sparing hysterectomy.21,22 Alternatively, patients who undergo hysterectomy may have underlying conditions (eg, chronic pelvic pain) that predispose to subsequent surgery.
Approximately 75% of hysterectomies in this study were vaginal, which is higher than the proportion (30–35%) reported elsewhere in the United States.23,24 In general, it is easier to perform an oophorectomy during abdominal than during vaginal hysterectomy. However, previous studies have shown that oophorectomy is feasible in 85% of attempted vaginal hysterectomies and that the likelihood of oophorectomy increases with surgical experience.25–27 Moreover, our concomitant oophorectomy rate of 39% (3,172 out of 8,103) is comparable with that of other studies with predominantly abdominal hysterectomy.28,29
Women in whom both ovaries were intact had a higher risk of subsequent oophorectomy. This difference was statistically significant even after adjusting for age. In contrast, an uncontrolled retrospective study using ultrasound surveillance reported a higher risk (7.6% compared with 3.5%) of subsequent oophorectomy in women with one intact ovary rather than both intact ovaries after hysterectomy.12 However, 78% of ovaries had normal histopathology, perhaps suggesting that the relationship between hysterectomy and reoperation was biased by surveillance procedures. Our study was not prone to this bias. The reason for this imbalance between unilateral and bilateral preservation may be related to the indication for hysterectomy during the index procedure. Unfortunately, a limitation of the current analysis is that we do not have full information regarding indications for the subsequent oophorectomy.
Although prophylactic oophorectomy during hysterectomy reduces the risk of ovarian cancer,30 women may have an increased risk of cardiovascular disease, dementia, and osteoporosis, and higher all-cause and cancer-specific mortality.4–7 These risks are highest for women undergoing oophorectomy before the age of 45 years, and they decline thereafter until the early sixth decade.7 Furthermore, after a median follow-up of 15 years, there was a 54% increase in osteoporotic fractures among postmenopausal women who had oophorectomy at a median age of 62 years.31 Conversely, the incidence of ovarian cancer increases with age, peaking at age 70 years.1 Although there is an ongoing debate about the pros and cons of oophorectomy, it is our professional opinion that it would be prudent to offer prophylactic oophorectomy only to women older than 60 years who are undergoing benign hysterectomy. Women with known risk factors for ovarian cancer are in a different category and should be counseled concerning the benefits of prophylactic oophorectomy.9,32
The large sample size with a median follow-up of 19.5 years (interquartile range 9.6–28.9 years, range less than 0.1–43.5 years) allowed for accurate estimates of the incidence of subsequent oophorectomy, as well as sufficient power for comparisons. The use of a referent group allowed us to estimate the true effect of hysterectomy on the incidence of oophorectomy as opposed to other factors. In this study, the referent group (women who had not undergone hysterectomy) was chosen from the same community and matched by age to the hysterectomy patients; therefore, we cannot draw conclusions about the incidence of oophorectomy in the referent group as a whole, but only in comparison to the case group.
Between 2000 and 2004 in the United States, three million women underwent hysterectomy;23 therefore, the question of ovarian preservation is an important public health issue. Some gynecologists suggest that the ovaries should be removed at the time of hysterectomy to avoid the risk of future surgery. This appears to be an unfounded concern, and women can be reassured that the odds are low that they will require subsequent oophorectomy. Women of all age groups should be thoroughly counseled regarding the risks and benefits of ovarian preservation.
1. Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Clin Obstet Gynecol 2007;50:354–61.
2. Christ JE, Lotze EC. The residual ovary syndrome. Obstet Gynecol 1975;46:551–6.
3. Naylor AC. Hysterectomy: analysis of 2,901 personally performed procedures. S Afr Med J 1984;65:242–5.
4. Parker WH, Broder MS, Chang E, Feskanich D, Farquhar C, Liu Z, et al.. Ovarian conservation at the time of hysterectomy and long-term health outcomes in the Nurses' Health Study. Obstet Gynecol 2009;113:1027–37.
5. Rocca WA, Grossardt BR, de Andrade M, Malkasian GD, Melton LJ III. Survival patterns after oophorectomy in premenopausal women: a population-based cohort study. Lancet Oncol 2006;7:821–8.
6. Shuster LT, Gostout BS, Grossardt BR, Rocca WA. Prophylactic oophorectomy in premenopausal women and long-term health. Menopause Int 2008;14:111–6.
7. Parker WH, Broder MS, Liu Z, Shoupe D, Farquhar C, Berek JS. Ovarian conservation at the time of hysterectomy for benign disease. Obstet Gynecol 2005;106:219–26.
8. Berek JS, Chalas E, Edelson M, Moore DH, Burke WM, Cliby WA, et al.; Society of Gynecologic Oncologists Clinical Practice Committee. Prophylactic and risk-reducing bilateral salpingo-oophorectomy: recommendations based on risk of ovarian cancer. Obstet Gynecol 2010;116:733–43.
9. Elective and risk-reducing salpingo-oophorectomy. ACOG Practice Bulletin No. 89. American College of Obstetricians and Gynecologists. Obstet Gynecol 2008;111:231–41.
10. Dekel A, Efrat Z, Orvieto R, Levy T, Dicker D, Gal R, et al.. The residual ovary syndrome: a 20-year experience. Eur J Obstet Gynecol Reprod Biol 1996;68:159–64.
11. Zalel Y, Lurie S, Beyth Y, Goldberger S, Tepper R. Is it necessary to perform a prophylactic oophorectomy during hysterectomy? Eur J Obstet Gynecol Reprod Biol 1997;73:67–70.
12. Plockinger B, Kolbl H. Development of ovarian pathology after hysterectomy without oophorectomy. J Am Coll Surg 1994;178:581–5.
13. Rocca WA, Yawn BP, St. Sauver JL, Grossardt BR, Melton LJ. History of the Rochester Epidemiology Project: half a century of medical records linkage in a US population. Mayo Clin Proc 2012;87:1202–13.
14. Melton LJ III. History of the Rochester Epidemiology Project. Mayo Clin Proc 1996;71:266–74.
16. St. Sauver JL, Grossardt BR, Yawn BP, Melton LJ III, Pankratz JJ, Brue SM, et al.. Data resource profile: the Rochester Epidemiology Project (REP) medical records linkage system. Int J Epidemiol 2012;41:1614–24.
17. St. Sauver JL, Grossardt BR, Leibson CL, Yawn BP, Melton LJ III, Rocca WA. Generalizability of epidemiological findings and public health decisions: an illustration from the Rochester Epidemiology Project. Mayo Clin Proc 2012;87:151–60.
18. Babalola EO, Bharucha AE, Schleck CD, Gebhart JB, Zinsmeister AR, Melton LJ III. Decreasing utilization of hysterectomy: a population-based study in Olmsted County, Minnesota, 1965-2002. Am J Obstet Gynecol 2007;196:214.e1–7.
19. Melton LJ III. The threat to medical-records research. N Engl J Med 1997;337:1466–70.
20. Schoenfeld DA. Sample-size formula for the proportional-hazards regression model. Biometrics 1983;39:499–503.
21. Farquhar CM, Sadler L, Harvey SA, Stewart AW. The association of hysterectomy and menopause: a prospective cohort study. BJOG 2005;112:956–62.
22. Moorman PG, Myers ER, Schildkraut JM, Iversen ES, Wang F, Warren N. Effect of hysterectomy with ovarian preservation on ovarian function. Obstet Gynecol 2011;118:1271–9.
23. Whiteman MK, Hillis SD, Jamieson DJ, Morrow B, Podgornik MN, Brett KM, et al.. Inpatient hysterectomy surveillance in the United States, 2000-2004. Am J Obstet Gynecol 2008;198:34.e1–7.
24. Keshavarz H, Hillis SD, Kieke BA, Marchbanks PA. Hysterectomy surveillance: United States, 1994-1999. MMWR Surveill Summ 2002;51:1–8.
25. Davies A, O’Connor H, Magos AL. A prospective study to evaluate oophorectomy at the time of vaginal hysterectomy. Br J Obstet Gynaecol 1996;103:915–20.
26. Sheth SS. Adnexectomy for benign pathology at vaginal hysterectomy without laparoscopic assistance. BJOG 2002;109:1401–5.
27. Gross CP, Nicholson W, Powe NR. Factors affecting prophylactic oophorectomy in postmenopausal women. Obstet Gynecol 1999;94:962–8.
28. Asante A, Whiteman MK, Kulkarni A, Cox S, Marchbanks PA, Jamieson DJ. Elective oophorectomy in the United States: trends and in-hospital complications, 1998-2006. Obstet Gynecol 2010;116:1088–95.
29. Lowder JL, Oliphant SS, Ghetti C, Burrows LJ, Meyn LA, Balk J. Prophylactic bilateral oophorectomy or removal of remaining ovary at the time of hysterectomy in the United States, 1979-2004. Am J Obstet Gynecol 2010;202:538.e1–9.
30. Sightler SE, Boike GM, Estape RE, Averette HE. Ovarian cancer in women with prior hysterectomy: a 14-year experience at the University of Miami. Obstet Gynecol 1991;78:681–4.
31. Melton LJ III, Khosla S, Malkasian GD, Achenbach SJ, Oberg AL, Riggs BL. Fracture risk after bilateral oophorectomy in elderly women. J Bone Miner Res 2003;18:900–5.
© 2013 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.
32. Finch A, Metcalfe KA, Chiang JK, Elit L, McLaughlin J, Springate C, et al.. The impact of prophylactic salpingo-oophorectomy on menopausal symptoms and sexual function in women who carry a BRCA mutation. Gynecol Oncol 2011;121:163–8.