Obstetrics & Gynecology:
Comparison of Transverse and Vertical Skin Incision for Emergency Cesarean Delivery
Wylie, Blair J. MD, MPH; Gilbert, Sharon MS, MBA; Landon, Mark B. MD; Spong, Catherine Y. MD; Rouse, Dwight J. MD; Leveno, Kenneth J. MD; Varner, Michael W. MD; Caritis, Steve N. MD; Meis, Paul J. MD; Wapner, Ronald J. MD; Sorokin, Yoram MD; Miodovnik, Menachem MD; O'Sullivan, Mary J. MD; Sibai, Baha M. MD; Langer, Oded MD; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Maternal–Fetal Medicine Units Network (MFMU)
From the Departments of Obstetrics and Gynecology, Columbia University, New York, New York; The Ohio State University, Columbus, Ohio; the University of Alabama at Birmingham, Birmingham, Alabama; the University of Texas Southwestern Medical Center, Dallas, Texas; the University of Utah, Salt Lake City, Utah; the University of Pittsburgh, Pittsburgh, Pennsylvania; Wake Forest University Health Sciences, Winston-Salem, North Carolina; Thomas Jefferson University, Philadelphia, Pennsylvania; Wayne State University, Detroit, Michigan; the University of Cincinnati, Cincinnati, Ohio; the University of Miami, Miami, Florida; the University of Tennessee, Memphis, Tennessee; the University of Texas at San Antonio, San Antonio, Texas; and the George Washington University Biostatistics Center, Washington, DC; and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland.
*For a list of other members of the NICHD MFMU, see the Appendix online at http://links.lww.com/AOG/A177.
Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD21410, HD21414, HD27860, HD27861, HD27869, HD27905, HD27915, HD27917, HD34116, HD34122, HD34136, HD34208, HD34210, HD36801).
The authors thank Francee Johnson, BSN, for protocol development and coordination between clinical research centers; Elizabeth Thom, PhD, for protocol and data management and statistical analysis; and John C. Hauth, MD, for protocol development and oversight.
Presented at the 53rd Annual Scientific Meeting of the Society for Gynecologic Investigation, March 22–25, 2006, Toronto, Canada.
Dr. Spong, Associate Editor of Obstetrics & Gynecology, was not involved in the review or decision to publish this article.
Corresponding author: Blair J. Wylie, MD, MPH, Department of Obstetrics and Gynecology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114; e-mail: firstname.lastname@example.org.
Financial Disclosure Dr. Landon received honoraria for doing grand rounds at various institutions and travel and accommodation expenses covered or reimbursed for grand rounds. Dr. Leveno received royalties for the Williams Obstetrics textbook. Dr. Varner received grants or grants pending from the National Institute of Child Health and Human Development (NICHD) for research conducted with funding from the NICHD Maternal–Fetal Medicine Units Network. Dr. Miodovnik received a grant, NIH-NICHD HD-27905-05 (until 2003). Dr. O'Sullivan was reimbursed for travel expenses related to this study by the NICHD; participated in the data monitoring committee after no longer a member of the study group and the compensation for travel and hotel was reimbursed by the NICHD; received a grant or has grants pending from the National Heart, Lung and Blood Institute for The Women's Health Initiative (WHI; The National Children's Study, sponsored by the National Institutes of Health); travel and accommodation expenses were reimbursed by NHLBI for the WHI annual meeting. The other authors did not report any potential conflicts of interest.
OBJECTIVE: To compare incision-to-delivery intervals and related maternal and neonatal outcomes by skin incision in primary and repeat emergent cesarean deliveries.
METHODS: From 1999 to 2000, a prospective cohort study of all cesarean deliveries was conducted at 13 hospitals comprising the Eunice Kennedy Shriver National Institute of Child Health and Human Development's Maternal–Fetal Medicine Units Network. This secondary analysis was limited to emergent procedures, defined as those performed for cord prolapse, abruption, placenta previa with hemorrhage, nonreassuring fetal heart rate tracing, or uterine rupture. Incision-to-delivery intervals, incision-to-closure intervals, and maternal outcomes were compared by skin-incision type (transverse compared with vertical) after stratifying for primary compared with repeat singleton cesarean delivery. Neonatal outcomes were compared by skin-incision type.
RESULTS: Of the 37,112 live singleton cesarean deliveries, 3,525 (9.5%) were performed for emergent indications of which 2,498 (70.9%) were performed by transverse and the remaining 1,027 (29.1%) by vertical incision. Vertical skin incision shortened median incision-to-delivery intervals by 1 minute (3 compared with 4 minutes, P<.001) in primary and 2 minutes (3 compared with 5 minutes, P<.001) in repeat cesarean deliveries. Total median operative time was longer after vertical skin incision by 3 minutes in primary (46 compared with 43 minutes, P<.001) and 4 minutes in repeat cesarean deliveries (56 compared with 52 minutes, P<.001). Neonates delivered through a vertical incision were more likely to have an umbilical artery pH of less than 7.0 (10% compared with 7%, P=.02), to be intubated in the delivery room (17% compared with 13%, P=.001), or to be diagnosed with hypoxic ischemic encephalopathy (3% compared with 1%, P<.001).
CONCLUSION: In emergency cesarean deliveries, neonatal delivery occurred more quickly after a vertical skin incision, but this was not associated with improved neonatal outcomes.
LEVEL OF EVIDENCE: II
Since its initial description in 1897 by Pfannenstiel,1 a transverse suprapubic incision has been used frequently in both obstetric and gynecologic surgeries. As initially described, the Pfannenstiel incision includes dissection of the rectus muscles from the overlying fascia and ligation of any perforating vessels encountered. In emergency situations, tradition has taught that abdominal entry at the time of cesarean delivery may be facilitated more rapidly through a midline vertical skin incision because rectus dissection is not required and perforating vessels are thus not encountered.2 The Pfannenstiel incision is cosmetically more attractive than a vertical incision, is familiar to the obstetric surgeon, and may be associated with less postoperative pain and a lower risk of hernia formation, leading many practitioners to choose this incision location even in emergencies.3
Randomized evaluations of skin incisions for cesarean delivery have been limited to comparisons between the Pfannenstiel and modifications of this transverse skin incision such as the muscle-splitting Maylard incision or the Joel-Cohen incision during which tissue layers are opened bluntly and dissection of the rectus muscles is not required. In these comparisons, the Joel-Cohen entry appears to offer certain advantages, including shorter incision-to-delivery intervals, less blood loss, shorter operating time, reduced time to oral intake, shorter duration of postoperative pain, and a shorter length of stay.4,5
The literature comparing transverse with vertical skin incisions for cesarean delivery is sparse. One study compared 619 cesarean deliveries performed by midline incision with 328 performed by Pfannenstiel skin incision and found no difference in postoperative complications such as wound healing or wound hematoma.6 The time required to deliver the neonate was not compared, and both elective and emergency deliveries were included.
The purported shorter incision time with a vertical incision has not been rigorously confirmed. Therefore, the purpose of this analysis was to compare incision-to-delivery intervals, total operative time, and maternal and neonatal outcomes by skin incision (transverse compared with vertical) in a large cohort of women undergoing emergency cesarean delivery at multiple hospitals throughout the United States.
MATERIALS AND METHODS
The cesarean registry, a prospective observational study conducted by 13 institutions in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network between 1999 and 2002, was designed to assess several specific contemporary issues.7 During the first 2 years of the cohort, information concerning all cesarean births within the Maternal–Fetal Medicine Units Network was ascertained. During the second 2 years, data were collected only for repeat cesareans and attempted vaginal births after prior cesarean. For the current study, only data collected during the first 2 years of the study were analyzed so that there would not be an imbalance in the type of cesarean deliveries. Each participating network center and the data coordinating center received Institutional Review Board approval for this study.
Detailed information regarding maternal demographic characteristics, medical and obstetrical history, intrapartum course, postpartum complications diagnosed before hospital discharge, and neonatal outcome was abstracted directly from maternal and neonatal charts by specially trained and certified research nurses. Longer-term maternal outcomes such as chronic pain, hernia formation, and cosmetic satisfaction were not available from the registry.
This analysis was limited to singleton emergency cesarean deliveries defined as those indicated to be emergent on individual record review that were performed for a diagnosis of umbilical cord prolapse, abruption, placenta previa with hemorrhage, nonreassuring fetal heart rate tracing, or uterine rupture. Stillbirths (n=27) were excluded because this could potentially influence the swiftness of delivery. Skin incisions were coded as either transverse or vertical. Skin incision, neonatal delivery, and skin closure times were ascertained from intraoperative records and used to calculate incision-to-delivery and incision-to-closure intervals in minutes.
Baseline variables and maternal delivery characteristics were compared by skin-incision type. Categorical variables were compared using the Pearson's chi-square or the Fisher exact test. Continuous variables were compared by the Wilcoxon rank sum test. Time intervals were analyzed by transverse compared with vertical skin-incision type after stratifying by primary compared with repeat cesarean delivery. Analysis of covariance was conducted after stratifying by primary and repeat cesarean deliveries to compare the mean differences in time intervals between the skin incision groups adjusting for body mass index at delivery.8 Analysis was confirmed using rank analysis of covariance because the data violated the normality assumption of the residuals by the Kolmogorov-Smirnov test. In addition, a subgroup analysis of incision-to-delivery intervals by indication for emergent delivery was performed. For maternal outcomes, the cohort was compared by type of skin incision after stratifying by primary compared with repeat cesarean delivery. Neonatal outcomes were compared by type of skin incision. Nominal two-sided probability values are reported with statistical significance defined as P<.05. No adjustments were made for multiple comparisons. Statistical analyses were performed using SAS software (SAS Institute, Inc, Cary, NC).
During 1999 and 2000, a total of 184,387 women delivered in Maternal–Fetal Medicine Units Network hospitals and 39,283 (21.3%) of these women underwent cesarean delivery. As shown in Figure 1, 3,525 (9.5%) emergency cesarean deliveries of singleton live births were available for analysis. A transverse incision was performed in 2,498 (70.9%) of these deliveries and vertical skin incisions performed in the remaining 1,027 (29.1%). Vertical incisions were more commonly performed during emergent cesarean deliveries than during nonemergent cesarean deliveries (29.1% compared with 20.4%, P<.001). The proportion of women undergoing vertical incisions did not differ by indication for emergent delivery (P=.34).
Women delivered by a transverse skin incision had a lower body mass index at delivery and were more likely to be nulliparous and white (Table 1). Women with a transverse skin incision were more likely to be undergoing a primary cesarean delivery compared with those in the vertical group (84% compared with 81%, P=.01) (Table 2). There were no other differences in assessed delivery characteristics.
In primary emergency cesarean deliveries, the median incision-to-delivery interval was 1 minute longer in women with a transverse skin incision when compared with those having vertical incisions (median 4, interquartile range 2–7 compared with median 3, interquartile range 2–4, P<.001) (Table 3). Among women undergoing repeat emergency cesarean deliveries, the median incision-to-delivery was 2 minutes longer with a transverse incision (median 5, interquartile range 3–9 compared with median 3, interquartile range 2–6, P<.001) (Table 3). Even after adjusting for body mass index at delivery using analysis of covariance, both primary and repeat cesarean deliveries had longer mean incision-to-delivery intervals with transverse incisions. For primary cesareans, the adjusted mean difference was 2.0 minutes (95% confidence interval 1.5 to 2.4, P<.001). For repeat cesareans, the adjusted mean difference was 1.6 minutes (95% confidence interval 0.6 to 2.6, P=.002). Despite longer incision-to-delivery intervals, the median total operative time was shorter by 3 minutes in primary cesarean deliveries and by 4 minutes in repeat cesarean deliveries for surgeries performed through a transverse skin incision (Table 3).
Longer incision-to-delivery intervals by transverse incision occurred both among centers that performed the majority of their emergency cesarean deliveries by transverse skin incision as well as among those primarily performing vertical incisions (data not shown). In subgroup analysis by indication for emergent cesarean delivery, a longer incision-to-delivery interval was again evident for transverse incisions performed for nonreassuring fetal tracings, abruptions, or cord prolapse. The longer intervals did not reach statistical significance in the previa with hemorrhage or uterine rupture subgroup perhaps secondary to a small sample size (Table 4).
Table 5 demonstrates selected maternal outcomes. There were no differences identified in the risk of intraoperative injury (broad ligament hematoma, cystotomy, bowel injury, ureteral injury) or postoperative ileus by type of skin incision. The frequency of wound infections and wound hematomas was similar between the two skin incision groups. Among women with vertical skin incisions, postpartum transfusions were more common both after primary (7% compared with 5%, P=.01) and repeat cesarean delivery (14% compared with 8%, P=.02). Among primary emergency cesarean deliveries, there was an increased incidence of postpartum endometritis in women delivered by vertical skin incisions (15% compared with 11%, P=.006). Length of stay after discharge was similar in both groups.
Despite shorter incision-to-delivery intervals, neonates delivered through a vertical incision were more likely to be intubated in the delivery room, to have an umbilical artery pH less than 7.0, or to be diagnosed with hypoxic ischemic encephalopathy (Table 6). There were no differences in neonatal outcomes by skin-incision type after cord prolapse, the subgroup that was delivered the swiftest (data not shown).
This secondary analysis of a large cohort of women undergoing emergency cesarean delivery sought to answer the question of whether the skin incision, transverse compared with vertical, is associated with a difference in the incision-to-delivery time, total operative time, maternal complications, or adverse neonatal outcomes. In this study, transverse skin incision lengthened the median incision-to-delivery interval by 1 minute for primary cesarean deliveries and by 2 minutes for repeat cesarean deliveries. Our sample size allowed for more than 80% power to detect a 0.25 standard deviation for the incision-to-delivery interval between the vertical and transverse incision groups in both primary and repeat cesarean deliveries.
We recognize that differences in speed of entry after the two incision locations may vary by institution or by individual surgeon. Nonetheless, in our cohort, newborn extraction was swifter after a vertical incision, even in centers that performed the majority of emergency deliveries by transverse incision.
It is difficult to codify the urgency of delivery. Our cohort, despite being limited to emergency cesarean deliveries, likely contains a range of urgency as demonstrated by the finding that neonates were delivered in less than 2 minutes in only 25% of our sample. The subgroup analysis by indication for delivery confirmed longer incision-to-delivery intervals among women delivered through transverse skin incisions in the situation of cord prolapse, considered to be perhaps more uniformly urgent than other indications with a more variable range of urgency.
Although this study validates traditional teaching that abdominal entry is quickest after vertical skin incision, at least in the setting of large teaching institutions, speed for speed's sake alone cannot be advocated without addressing whether the identified time difference is clinically significant in improving neonatal outcome without increasing significant maternal complications. Immediate intraoperative and postoperative maternal complications were similar between the groups with the primary exception of an increase in postpartum transfusions for both primary and repeat cesarean deliveries after vertical skin incisions. The proportion of women undergoing emergent cesarean delivery for hemorrhagic situations (abruption, previa with hemorrhage) did not differ between the transverse and the vertical skin incision groups; nonetheless, there are a number of other variables that could affect the need for postpartum transfusion such as preoperative hemoglobin or intraoperative or postoperative uterine atony that were not assessed in this analysis. The identified differences in transfusion rates could be attributable, at least in part, to uncontrolled confounding factors rather than being a reflection of the skin-incision type. Postpartum endometritis was also more common after vertical skin incisions in primary cesarean deliveries, although it is difficult to hypothesize how the incision location might affect this. Again, this may reflect underlying confounding conditions not controlled for in the analysis linked with both incision and infection.
Despite a statistically significant difference in incision-to-delivery time by skin-incision type, neonatal outcomes were not improved among those delivered through a vertical skin incision. In fact, we found improved neonatal outcomes after delivery through a transverse incision. Our results must be interpreted with caution because our study was limited by its observational nature and the potential for confounding that would not have been present if this had been a randomized clinical trial. Women were not randomized to skin-incision type, and the rationale for why a physician chose a particular skin incision was not captured in the database. In repeat cesarean deliveries, for instance, we do not know the location of the prior skin incision and whether this influenced the current incision type.
Despite data being collected contemporaneously to the delivery, our analysis was unable to quantify the degree of urgency with which an emergency cesarean delivery was performed. Our data may simply demonstrate that the sickest fetuses were delivered the quickest. Although transverse incisions were used more frequently than vertical incisions in both emergent and nonemergent cases, in this cohort, the frequency of vertical incision use was increased among emergent cases. Perhaps vertical incisions were chosen in the most urgent situations, biasing the results toward an apparent time advantage and an apparent neonatal disadvantage with this approach. Individual surgeon experience was also not assessed and may have impacted incision choice, swiftness of the delivery interval, and outcome.
In a separate publication from this registry analyzing the effects of decision-to-incision intervals on neonatal outcomes in emergency cesarean delivery, adverse neonatal outcomes were not increased in emergency cesarean deliveries performed more than 30 minutes after the decision to operate.9 It is therefore not surprising that the additional 1 to 2 minutes saved by performing vertical skin incisions did not translate into improved newborn outcomes given the absence of a measurable negative effect with the much longer time intervals in the decision-to-incision analysis. Nonetheless, in certain emergent situations such as a cord prolapse without a detectable fetal heart rate or a profound prolonged bradycardia, the additional 1 to 2 minutes saved by a vertical skin incision could perhaps be significant.
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