Fifty percent of obese women (n=328) had a cesarean delivery (49% [n=160] electively and 51% [n=168] as an emergency), compared with 22% of comparison women (n=140) (adjusted OR 3.50; 95% CI 2.72–4.51). The most common indications for elective cesarean delivery were previous cesarean delivery (54%, n=86), abnormal fetal presentation (breech, transverse, or unstable lie [18%, n=28]), and maternal medical complications (9%, n=15). Obese women were six times more likely to have general anesthesia for delivery than comparison women (adjusted OR 6.35; 95% CI 2.63–15.3) and had significantly more problems with other anesthesia methods (Table 3). Seventy-three women (22% of those who underwent cesarean delivery) had a postoperative complication; the most frequent were wound infection (n=48, 66%) or wound dehiscence (n=10, 14%).
No women died in either group. Pregnancy outcomes are known for 652 of the 659 obese women with ongoing pregnancies in the third trimester. These women delivered a total of 671 infants, including 15 pairs of twins and 2 sets of triplets. Fifty-nine of 635 singleton infants (9%) born to obese women had birth weights of 4,500 g or more; 12 of 625 singleton infants of comparison women (2%) weighed 4,500 g or more at birth (OR 5.23; 95% CI 2.81–9.74). One quarter of the infants with birth weights of 4,500 g or more were born to extremely obese women with preexisting or gestational diabetes (14/59, 24%).
There were eight stillbirths and three early neonatal deaths among the infants born to obese women, representing a perinatal morbidity rate of 16 per 1,000 total births to extremely obese women (95% CI 8–29 per 1,000 total births). All the neonatal deaths occurred in infants born before 32 weeks of gestation; two of the stillbirths occurred in women with preexisting or gestational diabetes. There were five stillbirths and no early neonatal deaths among the infants born to comparison women, a perinatal mortality rate of 8 per 1,000 total births (95% CI 3–18 per 1,000 total births; OR 2.12; 95% CI 0.77–5.88).
This study of an estimated 764,387 women giving birth has revealed on a national basis the extent of the problem of extreme obesity in pregnancy in the United Kingdom. More than 1 of every 1,200 women giving birth in the United Kingdom has a BMI of 50 or greater. Given current trends,2 the number of extremely obese women in pregnancy is likely to increase, thus emphasizing the importance of surveillance and evidence to address primary prevention and guide appropriate management and service provision. Extremely obese women are at higher risk for almost all the pregnancy complications we examined. These increased risks are not explained by differences in age, ethnic group, socioeconomic group, smoking, or parity. More extremely obese women entered pregnancy with known medical factors relating to adverse outcomes, including 5% with preexisting diabetes and 6% with hypertension. The proportion of extremely obese women with preexisting diabetes is higher than reported in other studies of women with more moderate obesity. For example, 2.2% of women in Nova Scotia weighing 120 kg or more in pregnancy had preexisting diabetes5; 0.8% of women with a BMI of 30 or greater delivering in London had preexisting diabetes.6
More than one in five extremely obese women developed a hypertensive disorder in pregnancy; nearly one in ten developed preeclampsia, a more than four-fold increase in odds over the comparison group. Other recent studies of women with more moderate degrees of obesity have also reported an increased risk of hypertensive disorders, but generally with a lower absolute and relative risk.6,17 Gestational diabetes was diagnosed in 11% of extremely obese women, and nearly 70% of these women required insulin. The odds of gestational diabetes in extremely obese women were seven times higher than in the comparison group. These figures are compatible with other studies examining women with morbid obesity,4,5,18 and higher than in studies examining women with more moderate obesity. We noted an ethnic difference in the risk of gestational diabetes requiring insulin, such that the increase in risk was limited to white women. There were no ethnic differences in the risks of gestational diabetes per se, thus our results do not support the suggestion of underdiagnosis, but may reflect differences either in the way ethnic minority women are treated for gestational diabetes or alternatively between ethnic groups in the responsiveness of gestational diabetes to measures such as diet modification.
Obesity is a recognized risk factor for shoulder dystocia,19 yet shoulder dystocia was uncommon in this extremely obese cohort and not significantly different from the rate observed in the comparison group, despite nearly 1 in 10 of the infants of obese mothers weighing 4,500 g or more at birth. The most likely explanation for this is the extremely high rate of cesarean delivery in the obese group (50%). A higher rate of cesarean delivery in obese women has been identified in recent systematic reviews,9,20 with a pooled estimate of 38% in the morbidly obese group. Thus our results suggest that the risk of cesarean delivery is even higher in extremely obese women than in less obese women. Further work is required to explore whether this is due to obstetrician choice or due to other factors related to obesity such as inefficient uterine activity.
The outcomes for infants of extremely obese women were also generally poorer than for the comparison group. Infants were more likely to be born preterm and were more likely to weigh 4,500 g or greater at birth. Perinatal mortality was nonsignificantly increased in the infants of extremely obese women, primarily due to a higher number of neonatal deaths. Other studies consistently report an increase in risk of both stillbirth21 and neonatal death10,19,22,23 associated with maternal obesity, with an approximate doubling of the risk in obese mothers. In our study, all the neonatal deaths occurred in infants born preterm. The observed associations between maternal obesity and preterm birth are complex, with some studies reporting that obesity is protective,6,24,25 others reporting increased risk only in certain subgroups,11 and further studies suggesting an independent increase in risk associated with maternal obesity.26 In this cohort study of women with extreme obesity, we observed a significant increase in the risk of preterm birth at less than 37 weeks of gestation, independent of age, parity, socioeconomic status, smoking, or ethnicity. We did not find a significant increase in risk of delivery at less than 32 weeks of gestation, possibly because of a relatively small number of events and a consequent lack of study power. These findings would lead us to suggest that some of the conflicting results of other studies of obesity and preterm birth may be due to variable inclusion of extremely obese women. Subfertility or problems with conception were reported in almost 1 in every 10 extremely obese women, and the relatively high multiple pregnancy rate suggests that some women conceived using assisted reproductive techniques. It is important that the risks of pregnancy complications should be discussed before assisting extremely obese women to conceive.
This study shows the implications of the obesity epidemic for maternity services. Extremely obese pregnant women received care from a wider range of health professionals than comparison women; they had more complex pregnancies and more interventions, and were more likely to give birth to preterm and high birth weight infants, both groups susceptible to long-term health problems. Although we did not document any instances of lack of facilities contributing to poor outcomes for obese pregnant women, basic equipment to enable health professionals to care appropriately, and safely, for these women was not universally available. Adverse outcomes for women and staff, as well as a basic lack of comfort, are likely to result if equipment provision remains inadequate. Similar themes have been identified in recent qualitative studies27 and reviews.28 In the context of an increasing birth rate and rising levels of obesity,2,16 this is an area that needs addressing urgently.
For pragmatic reasons, and to maintain a link with the notification of extremely obese women, we identified the comparison group as women delivering immediately before the extremely obese women, provided their BMI was less than 50. This comparison group represents the general population of women giving birth in the United Kingdom, and hence has a BMI range between 16 and 48. Because a large proportion of extremely obese women underwent cesarean delivery, the comparison group was also more likely to have delivered during the daytime than the general population, and may thus be a higher-risk cohort. It should therefore be noted that the use of this comparison group may actually underestimate the risks associated with extreme obesity.
3. Bhattacharya S, Campbell DM, Liston WA, Bhattacharya S. Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health 2007;7:168.
4. Callaway LK, Prins JB, Chang AM, McIntyre HD. The prevalence and impact of overweight and obesity in an Australian obstetric population. Med J Aust 2006;184:56–9.
5. Robinson HE, O'Connell CM, Joseph KS, McLeod NL. Maternal outcomes in pregnancies complicated by obesity. Obstet Gynecol 2005;106:1357–64.
6. Sebire NJ, Jolly M, Harris JP, Wadsworth J, Joffe M, Beard RW, et al. Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London. Int J Obes Relat Metab Disord 2001;25:1175–82.
7. Usha Kiran TS, Hemmadi S, Bethel J, Evans J. Outcome of pregnancy in a woman with an increased body mass index. BJOG 2005;112:768–72.
8. Catalano PM, Ehrenberg HM. The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG 2006;113:1126–33.
9. Poobalan AS, Aucott LS, Gurung T, Smith WC, Bhattacharya S. Obesity as an independent risk factor for elective and emergency caesarean delivery in nulliparous women: systematic review and meta-analysis of cohort studies. Obes Rev 2009;10:28–35.
10. Kristensen J, Vestergaard M, Wisborg K, Kesmodel U, Secher NJ. Pre-pregnancy weight and the risk of stillbirth and neonatal death. BJOG 2005;112:403–8.
11. Smith GC, Shah I, Pell JP, Crossley JA, Dobbie R. Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort study. Am J Public Health 2007;97:157–62.
12. Kleiser C, Schaffrath Rosario A, Mensink GB, Prinz-Langenohl R, Kurth BM. Potential determinants of obesity among children and adolescents in Germany: results from the cross-sectional KiGGS Study. BMC Public Health 2009;9:46.
13. Lewis G, editor. Why mothers die 2000–2002. Confidential Enquiries into Maternal Deaths in the United Kingdom. London (UK): Royal College of Obstetricians and Gynaecologists; 2004.
14. Lewis GE, editor. The Confidential Enquiry into Maternal and Child Health (CEMACH). Saving mothers lives: reviewing maternal deaths to make childhood safer: 2003–2005. London (UK): CEMACH; 2007.
15. Knight M, Kurinczuk JJ, Tuffnell D, Brocklehurst P. The UK Obstetric Surveillance System for rare disorders of pregnancy. BJOG 2005;112:263–5.
16. Office for National Statistics. Key Population and Vital Statistics 2007. Newport (UK): Office for National Statistics, 2009.
17. Leung TY, Leung TN, Sahota DS, Chan OK, Chan LW, Fung TY, et al. Trends in maternal obesity and associated risks of adverse pregnancy outcomes in a population of Chinese women. BJOG 2008;115:1529–37.
18. Chu SY, Callaghan WM, Kim SY, Schmid CH, Lau J, England LJ, et al. Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care 2007;30:2070–6.
19. Cedergren MI. Maternal morbid obesity and the risk of adverse pregnancy outcome. Obstet Gynecol 2004;103:219–24.
20. Chu SY, Kim SY, Schmid CH, Dietz PM, Callaghan WM, Lau J, et al. Maternal obesity and risk of cesarean delivery: a meta-analysis. Obes Rev 2007;8:385–94.
21. Chu SY, Kim SY, Lau J, Schmid CH, Dietz PM, Callaghan WM, et al. Maternal obesity and risk of stillbirth: a metaanalysis. Am J Obstet Gynecol 2007;197:223–8.
22. Chen A, Feresu SA, Fernandez C, Rogan WJ. Maternal obesity and the risk of infant death in the United States. Epidemiology 2009;20:74–81.
23. Nohr EA, Vaeth M, Bech BH, Henriksen TB, Cnattingius S, Olsen J. Maternal obesity and neonatal mortality according to subtypes of preterm birth. Obstet Gynecol 2007;110:1083–90.
24. Hendler I, Goldenberg RL, Mercer BM, Iams JD, Meis PJ, Moawad AH, et al. The Preterm Prediction Study: association between maternal body mass index and spontaneous and indicated preterm birth. Am J Obstet Gynecol 2005;192:882–6.
25. Schieve LA, Cogswell ME, Scanlon KS, Perry G, Ferre C, Blackmore-Prince C, et al. Prepregnancy body mass index and pregnancy weight gain: associations with preterm delivery. The NMIHS Collaborative Study Group. Obstet Gynecol 2000;96:194–200.
26. Nohr EA, Bech BH, Vaeth M, Rasmussen KM, Henriksen TB, Olsen J. Obesity, gestational weight gain and preterm birth: a study within the Danish National Birth Cohort. Paediatr Perinat Epidemiol 2007;21:5–14.
27. Heslehurst N, Lang R, Rankin J, Wilkinson JR, Summerbell CD. Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services. BJOG 2007;114:334–42.
© 2010 by The American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.
28. Heslehurst N, Simpson H, Ells LJ, Rankin J, Wilkinson J, Lang R, et al. The impact of maternal BMI status on pregnancy outcomes with immediate short-term obstetric resource implications: a meta-analysis. Obes Rev 2008;9: 635–83.