Obstetrics & Gynecology:
The Relationship Between Female Genital Cutting and Obstetric Fistulae
Browning, Andrew MB, BS; Allsworth, Jenifer E. PhD; Wall, L. Lewis MD, DPhil
From the Barhirdar Hamlin Fistula Centre, Barhirdar, Ethiopia; and the Department of Obstetrics and Gynecology and the Department of Anthropology, Washington University, St. Louis, Missouri.
Dr. Allsworth was supported in part by Clinical and Translational Science Award UL1RR024992 and by grant KL2RR024994 from the National Center for Research Resources, a component of the National Institutes of Health, and National Institutes of Health Roadmap for Medical Research.
The authors thank Birhanu Menber for assisting with patient care and collecting data.
The contents of this article are solely the responsibility of the authors and do not necessarily represent the official view of the National Center for Research Resources or the National Institutes of Health.
Corresponding author: L. Lewis Wall, MD, DPhil, Department of Obstetrics and Gynecology, Washington University School of Medicine, Campus Box 8064, 660 South Euclid Avenue, St. Louis, MO 63110; e-mail: firstname.lastname@example.org.
Financial Disclosure The authors did not report any potential conflicts of interest.
OBJECTIVE: To evaluate any association between female genital cutting and vesicovaginal fistula formation during obstructed labor.
METHODS: A comparison was made between 255 fistula patients who had undergone type I or type II female genital cutting and 237 patients who had not undergone such cutting. Women were operated on at the Barhirdar Hamlin Fistula Centre in Ethiopia. Data points used in the analysis included age; parity; length of labor; labor outcome (stillbirth or not); type of fistula; site, size, and scarring of fistula; outcomes of surgery (fistula closed; persistent incontinence with closed fistula; urinary retention with overflow; site, size, and scarring of any rectovaginal fistula; and operation outcomes), and specific methods used during the operation (use of a graft or not, application of a pubococcygeal or similar autologous sling, vaginoplasty, catheterization of ureters, and flap reconstruction of vagina). Primary outcomes were site of genitourinary fistula and persistent incontinence despite successful fistula closure.
RESULTS: The only statistically significant differences between the two groups (P=.05) were a slightly greater need to place ureteral catheters at the time of surgery in women who had not undergone a genital cutting operation, a slightly higher use of a pubococcygeal sling at the time of fistula repair, and a slightly longer length of labor (by 0.3 day) in women who had undergone genital cutting.
CONCLUSION: Type I and type II female genital cutting are not independent causative factors in the development of obstetric fistulae from obstructed labor.
LEVEL OF EVIDENCE: II
Obstetric fistula is a catastrophic childbirth injury that currently afflicts as many as 3.5 million women in Africa and Asia, with up to 130,000 new cases occurring each year.1 In the vast majority of cases, obstetric fistulae are caused by ischemic necrosis of the tissues of the vesicovaginal septum that are trapped between the mother's bony pelvis and the presenting fetal part (usually the head). In parts of the world without prompt access to emergency obstetric care, women may remain in obstructed labor for 3 or 4 days (or longer) without delivery.2,3 After delivery (usually of a stillborn fetus), the necrotic tissue sloughs away to reveal the fistula.
Female genital cutting (also commonly referred to as either “female circumcision” or “female genital mutilation”) refers to “all procedures involving partial or total removal of the external female genitalia or other injury to the female genital organs for non-medical reasons.”4 Such practices are common in traditional cultures throughout much of sub-Saharan Africa. The World Health Organization (WHO) classifies these cutting procedures into four main groups.4 Type I genital cutting consists of partial or total removal of the clitoris or the prepuce (clitoridectomy) or both. Type II procedures involve partial or total removal of the clitoris and the labia minora, with or without excision of the labia majora (excision). The most extensive mutilation (type III or “infibulation”) narrows the vaginal orifice and creates a covering seal by cutting and appositioning the labia minora or labia majora or both, often involving excision of the clitoris as well. Type IV (miscellaneous operations) includes all other harmful genital procedures carried out for nonmedical purposes, such as pricking, piercing, incising, scraping, and cauterization.
Over the past 20 years, female genital cutting has undergone increasingly critical scrutiny because of the adverse health consequences suffered by the affected women and the human rights implications entailed by the continuance of such practices.5,6 As a result of this increasing attention, the belief has arisen in some quarters that the eradication of female genital mutilation would also eliminate obstetric fistula.5,7 Only a small number of studies have looked at potential linkages between female genital cutting and women's reproductive health.8–17 Our study directly addresses the presumed association between female genital cutting and obstetric fistula formation. Our objective was to evaluate any association between female genital cutting and vesicovaginal fistula formation during obstructed labor.
It has long been taught that the level at which obstruction occurs during labor determines the site at which the fistula will subsequently develop.1,18 Thus, if labor becomes obstructed at the pelvic brim, the resulting ischemic necrosis will occur in this area and the vesicovaginal fistula that results should be high in the pelvis, perhaps in a juxtacervical location. In similar fashion, if labor becomes obstructed at the pelvic outlet, necrosis would occur lower in the reproductive tract and the fistula should appear closer to the urethra. Because female genital cutting types I through III involve the external genitalia, if scarring from these procedures is the cause of obstructed labor, passage of the fetus through the pelvis should be normal until it reaches the level of the pelvic outlet. Fistulae that result from external genital scarring should therefore be found extremely low in the pelvis, and a high proportion of these fistulae should involve the urethra. One would also expect to find more urethral damage in fistula patients who had been subjected to previous female genital cutting. The main predictor of persistent urinary incontinence after fistula closure has also been shown to be the presence of urethral injury.19–23 Thus, if female genital mutilation is a major cause of obstetric fistula formation, there should also be a higher proportion of women with persistent urinary incontinence among those who have been subjected to such cutting procedures. If the obstruction was caused by scarring of the outlet and introitus rather than by obstruction against the bones higher in the pelvis, examination of a large series of cases might show differences in the initial presentation of the fistulae as well as differences in subsequent surgical outcome when comparing patients who have and who have not undergone genital cutting procedures. This article examines numerous variables in patients with obstetric fistulae who presented for care at the Barhirdar Hamlin Fistula Centre in northern Ethiopia with respect to the presence or absence of a history of genital cutting.
MATERIALS AND METHODS
The hospital notes of 1,000 consecutive patients who had been operated on for an obstetric fistula at the Barhirdar Hamlin Fistula Centre in Ethiopia between July 2005 and July 2008 were reviewed. Barhirdar, the capital of the Amhara Region, is located 540 km north of Addis Ababa. The Barhirdar Hamlin Fistula Centre is a satellite of the Addis Ababa Fistula Hospital. There is no formal research ethics committee at this hospital; therefore, permission to conduct the case review was obtained from the Barhirdar medical director. Cases were included in the analysis only if there was a definite notation in the chart as to the presence or absence of a prior female genital cutting procedure and only if the fistula was attributable to prolonged obstructed labor. These procedures were classified clinically according to the WHO system. The charts of 492 patients had a definite notation as to whether or not they had undergone female genital cutting: in 255 cases, some type of female genital mutilation was present, and in 237 cases, it was specifically noted that these women had not undergone such a procedure. The prevalence of female genital cutting varies greatly throughout Ethiopia, from an absence of this practice in Gambella to an incidence of 94% in Afar. In Barhirdar, approximately 81% of women have been “circumcised.”24 In this region of Ethiopia, most forms of genital cutting present as intermediate between types I and II in the WHO classification system; that is, affected women commonly have had the labia minora removed but the clitoris is left intact. At other times, the visible mutilation was “typical” for either a type I or type II procedure. Because the extent of the scarring was similar in these cases, we compared fistula patients either with or without genital mutilation.
Data points used in the analysis included age; parity; length of labor; labor outcome (stillbirth or not); type of fistula; site, size, and scarring of fistula as described by Goh's validated fistula classification system22,25,26; outcomes of surgery (fistula closed; persistent incontinence with closed fistula; urinary retention with overflow incontinence; site, size, and scarring of any rectovaginal fistula; operation outcomes), as well as specific methods used during the operation (use of a graft or not, application of a pubococcygeal or similar autologous sling, vaginoplasty, catheterization of ureters, and flap reconstruction of vagina). Four of the patients were excluded from this latter group, as they had no bladder remaining on which an operation could be performed: one from the non–female genital cutting group and three from the female genital cutting group.
We have used sling use as a surrogate marker for urethral involvement, as slings were used only for Goh type III and type IV fistulae. Similarly, vaginoplasty is used in this analysis as a surrogate marker for vaginal scarring, as this was only necessary in patients with moderate to severe vaginal scarring. Flap reconstruction of the vagina was used only when there was extensive vaginal loss and is also a surrogate marker for extensive vaginal loss. Ureteral catheterization (or not) reflects the position of the fistula in relation to the trigone/ureteric orifices. Catheterization was necessary only if the ureters were close to the edge of the fistula.
Our primary outcomes of interest, site of genitourinary fistula and persistent incontinence despite successful fistula closure, were used to determine the power for this analysis. For site of genitourinary fistula, we had 80% power; for persistent incontinence, our power was 86% to detect a difference of 5%, assuming an α value of 0.05. Power was estimated using nQuery Advisor version 7.0 (Statistical Solutions, Saugus, MA). Statistical analyses were conducted using SAS version 9.1 (SAS Institute Inc., Cary, NC). Continuous measures were compared using the Student t test. Categorical variables were initially compared using either the χ2 or the Fisher exact test. Relative risks associated with site of genitourinary fistula and persistent incontinence were estimated using Poisson regression with robust error variance. This analytic approach is appropriate in a cross-sectional study when a binary outcome is common.27
Detailed statistical comparisons are presented in Tables 1 through 4. In all measured parameters, the only significant differences between fistula patients with and without exposure to genital cutting was a slightly greater need to catheterize the ureters at the time of surgery in women who had not undergone genital cutting, and slightly higher use of a pubococcygeal sling at the time of fistula repair and a slightly longer (0.3 day) length of labor in patients who had undergone genital cutting. We also estimated relative risks for our primary outcomes, site of genitourinary fistula (relative risk 0.93, 95% confidence interval 0.85–1.02), and persistent incontinence (relative risk 0.92, 95% confidence interval 0.82–1.03). These results were essentially unchanged after adjustment for the potential confounding effects of age, parity, and days in labor.
There is a widespread belief that female genital cutting predisposes women to the development of obstetric fistulae,5–7 but little direct evidence substantiates this belief. Several authors have looked at obstetric outcomes among immigrant women in European countries who had undergone genital cutting procedures.8,14,16 Some of these studies have not found any differences in prolonged labor, need for forceps or cesarean delivery, fetal distress, or perinatal deaths when African immigrants are compared with noncut European women delivering at the same institutions.8,16 Although infibulated women (type III cutting) require anterior episiotomy/defibulation at the time of delivery, in one Swedish study, such women actually had shorter labors than did the noncut Swedish controls.16
Several studies from Africa show increases in obstetric complications—mainly perineal lacerations or stillbirths or both—among women who have undergone genital cutting operations.11,13 The WHO recently completed a prospective study of delivery outcomes among 28,393 women with singleton pregnancies presenting for delivery at 28 obstetric centers in Burkina Faso, Ghana, Kenya, Nigeria, Senegal, and Sudan, according to the presence or absence and type of genital cutting present.17 This study concluded that adverse outcomes increased according to the severity of the genital cutting, with significant increases in the risk for cesarean delivery, postpartum hemorrhage, episiotomy, extended maternal hospital stay, and the need for infant resuscitation at delivery. Female genital cutting appeared to lead to one or two additional perinatal deaths per 100 deliveries in these countries. Unfortunately, this study contained no data on obstetric fistulae.
Our study specifically examines the possible relationship between female genital cutting and obstetric fistula formation. We do not find any clear differences in the presentation, site, size, or degree of scarring in obstetric fistulae occurring in women who have undergone type I or type II genital cutting procedures compared with women with obstetric fistulae who have not been cut in this way. Although we found statistical significance (each with a value of P=.05) in the need for ureteral catheterization in women who had a fistula but who had not been cut and the need for a pubococcygeal sling at the time of fistula repair in women who had undergone a genital cutting procedure, we do not believe that either of these findings are of practical clinical significance. Geographic review of patient origins suggests that the slightly longer length of labor found in patients who had undergone genital cutting was attributable to their living in more remote locations, farther from medical help.
Surgical outcomes do not differ according to whether or not the woman has previously undergone female genital cutting, and physical examination gives the clear clinical impression that the amount of scarring left by type I and type II cutting procedures would not cause a prolonged obstructed labor. Both of these observations suggest that type I and type II genital cutting does not contribute to obstetric fistula formation during obstructed labor. Furthermore, statistical modeling using data from demographic and health surveys carried out in Malawi, Rwanda, Uganda, and Ethiopia have not found evidence that genital cutting contributes to fistula formation from obstructed labor.28
Our data are insufficient to show whether or not type III genital cutting (infibulation) contributes to obstructed labor and fistula formation, and further research on this topic is warranted. The common assumption is that increased scarring at the introitus produced by more radical forms of genital cutting could cause a delay in the second stage of labor which, in turn, might lead to an increased risk of fistula formation. Women who have undergone type III procedures usually require defibulation at the time of delivery,9,29 and data from Saudi Arabia on infibulated women suggest that they have a longer second stage during labor and an increased risk of postpartum hemorrhage; however, they do not appear to require cesarean delivery more often than noninfibulated women.9,29 Delivery data on infibulated immigrant Somali women now living in industrialized countries show higher rates of cesarean and operative vaginal delivery, as well as increased risks of perineal laceration and postpartum hemorrhage than do nonimmigrant women of the receiving countries.30–33 The reasons for these differences are unclear. Some authors suggest that poor communication and a lack of familiarity with special issues raised during the delivery of these women explains much of the increased perineal trauma and higher rates of cesarean delivery in these studies.33,34 In some patients, defibulation itself may create a fistula: at Barhirdar, two to three patients are seen each year who have undergone type III genital cutting and who present after labor with a fistula that has obviously been caused by a traditional birth attendant cutting open both the infibulated genitalia and the urinary tract at the time of delivery.
Although there is no clear mechanical association between type I and type II female genital cutting and obstetric fistula formation from obstructed labor, it is very clear that obstetric fistulae are prevalent in cultural areas where genital cutting practices are also common. Rather than being a cause of obstructed labor, we believe that female genital cutting is a marker for the presence of other important risk factors that combine to promote obstetric fistulae.1 Fistulae are found where the socioeconomic status of women is low, where early marriage is common and pregnancy occurs before pelvic growth is complete, where women's personal autonomy is highly restricted, where contraceptive choice is limited or nonexistent and fertility is high, where women are largely uneducated and have little political power, and where transportation is difficult and the medical infrastructure is inadequately developed so that timely access to emergency obstetric services is poor and those services are often of marginal quality. Together, these factors combine to produce high levels of maternal mortality and obstetric morbidity, of which the obstetric fistula is a common and tragic component. It should not be surprising that female genital cutting is commonly found within this same social milieu. Although the eradication of female genital cutting is desirable from the standpoints of both women's health and human rights, the elimination of these traditional genital operations will not eliminate the obstetric fistula as a complication of childbirth. Accomplishing this will require the presence of a trained attendant during every labor and timely, universal access to competent emergency obstetric services worldwide.
1. Wall LL. Obstetric vesicovaginal fistula as an international public health problem. Lancet 2006;368:1201–9.
2. Arrowsmith S, Hamlin EC, Wall LL. Obstructed labor injury complex: obstetric fistula formation and the multifaceted morbidity of maternal birth trauma in the developing world. Obstet Gynecol Surv 1996;51:568–74.
3. Wall LL, Karshima JA, Kirschner C, Arrowsmith SD. The obstetric vesicovaginal fistula: characteristics of 899 patients from Jos, Nigeria. Am J Obstet Gynecol 2004;190:1011–9.
4. World Health Organization. Eliminating female genital mutilation: an interagency statement UNAIDS, UNDP, UNECA, UNESCO, UNFPA, UNHCHR, UNHCR, UNICEF, UNIFEM, WHO. Geneva: World Health Organization; 2008.
5. Hosken FP. The Hosken report: genital and sexual mutilation of females. 4th ed. Lexington (MA): Women's International Network News; 1993.
6. Shell-Duncan B, Hernland Y, editors. Female “circumcision” in Africa: culture, controversy and change. Boulder (CO): Lynne Rienner Publishers; 2000.
7. Howson CP, Harrison PF, Hotra D, Law M, editors. In her lifetime: female morbidity and mortality in sub-Saharan Africa. Washington, DC: Board on International Health, Institute of Medicine, National Academy Press; 1996.
8. Berardi JC, Teillet JF, Godard J, Laloux V, Allane P, Franjou MH. Obstetrical consequences of female circumcision: study in 71 circumcised African women (in French). J Gynecol Obstet Biol Reprod (Paris) 1985;14:743–6.
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12. Morison L, Scherf C, Ekpo G, Pain K, West B, Coleman R, et al. The long-term reproductive health consequences of female genital cutting in rural Gambia: a community-based survey. Trop Med Int Health 2001;6:643–53.
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14. Essen B, Bodker B, Sjoberg NO, Gudmondsson S, Ostergren PO, Langhoff-Roose J. Is there an association between female circumcision and perinatal death? Bull World Health Organ 2002;80:629–32.
15. Slanger TE, Snow RC, Okonofua FE. The impact of female genital cutting on first delivery in southwest Nigeria. Stud Fam Plann 2002;33:173–84.
16. Essen B, Sjöberg NO, Gudmundsson S, Ostergren PO, Lindqvist PG. No association between female circumcision and prolonged labour: a case control study of immigrant women giving birth in Sweden. Eur J Obstet Gynecol Reprod Biol 2005;121:182–5.
17. WHO Study Group on Female Genital Mutilation and Obstetric Outcome. Female genital mutilation and obstetric outcome: WHO collaborative prospective study in six African countries. Lancet 2006;367:1835–41.
18. Elkins TE. Surgery for the obstetric vesicovaginal fistula: a review of 100 operations in 82 patients. Am J Obstet Gynecol 1994;170:1108–18.
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21. Browning A. The circumferential obstetric fistula: characteristics, management and outcomes. BJOG 2007;114:1172–6.
22. Goh JT, Browning A, Berhan B, Chang A. Predicting the risk of failure of closure of obstetric fistula and residual urinary incontinence using a classification system. Int Urogynecol J Pelvic Floor Dysfunct 2008;19:1659–62.
23. Nardos R, Browning A, Chen CC. Risk factors that predict failure after vaginal repair of obstetric vesicovaginal fistulae. Am J Obstet Gynecol 2009;200:578.e1–4.
24. Ethiopian Harmful Traditional Practices Association. Harmful practices in Ethiopia. Addis Ababa, Ethiopia: Ethiopian Harmful Traditional Practices Association; 2007.
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29. Rouzi AA, Aljhadali EA, Amarin ZO, Abduljabbar HS. The use of intrapartum defibulation in women with female genital mutilation. BJOG 2001;108:949–51.
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© 2010 The American College of Obstetricians and Gynecologists
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