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Obstetrics & Gynecology:
doi: 10.1097/AOG.0b013e3181cbd482
Original Research

An Integrated Intervention to Reduce Intimate Partner Violence in Pregnancy: A Randomized Controlled Trial

Kiely, Michele DrPH; El-Mohandes, Ayman A. E. MD, MPH; El-Khorazaty, M Nabil PhD; Gantz, Marie G. PhD

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Author Information

From the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland; the College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska; and RTI International, Rockville, Maryland.

Supported by grants 3U18HD030445, 3U18HD030447, 5U18HD31206, 3U18HD03919, 5U18HD036104, Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Center on Minority Health and Health Disparities.

Corresponding author: Michele Kiely, Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, 6100 Executive Blvd, Rockville, MD 20852-7510; e-mail: kielym@nih.gov.

Financial Disclosure: The authors did not report any potential conflicts of interest.

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Abstract

OBJECTIVE: To estimate the efficacy of a psycho-behavioral intervention in reducing intimate partner violence recurrence during pregnancy and postpartum and in improving birth outcomes in African-American women.

METHODS: We conducted a randomized controlled trial for which 1,044 women were recruited. Women were randomly assigned to receive either intervention (n=521) or usual care (n=523). Individually tailored counseling sessions were adapted from evidence-based interventions for intimate partner violence and other risks. Logistic regression was used to model intimate partner violence victimization recurrence and to predict minor, severe, physical, and sexual intimate partner violence.

RESULTS: Women randomly assigned to the intervention group were less likely to have recurrent episodes of intimate partner violence victimization (odds ratio [OR] 0.48, 95% confidence interval [CI] 0.29–0.80). Women with minor intimate partner violence were significantly less likely to experience further episodes during pregnancy (OR 0.48, 95% CI 0.26–0.86, OR 0.53, 95% CI 0.28–0.99) and postpartum (OR 0.56, 95% CI 0.34–0.93). Numbers needed to treat were 17, 12, and 22, respectively, as compared with the usual care group. Women with severe intimate partner violence showed significantly reduced episodes postpartum (OR 0.39, 95% CI 0.18–0.82); the number needed to treat was 27. Women who experienced physical intimate partner violence showed significant reduction at the first follow-up (OR 0.49, 95% CI 0.27–0.91) and postpartum (OR 0.47, 95% CI 0.27–0.82); the numbers needed to treat were 18 and 20, respectively. Women in the intervention group had significantly fewer very preterm neonates (1.5% intervention group, 6.6% usual care group; P=.03) and an increased mean gestational age (38.2±3.3 intervention group, 36.9±5.9 usual care group; P=.016).

CONCLUSION: A relatively brief intervention during pregnancy had discernible effects on intimate partner violence and pregnancy outcomes. Screening for intimate partner violence as well as other psychosocial and behavioral risks and incorporating similar interventions in prenatal care is strongly recommended.

CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00381823.

LEVEL OF EVIDENCE: I

Intimate partner violence is defined as a pattern of assaultive and coercive behaviors that includes the threat or infliction of physical, sexual, or psychological abuse that is used by perpetrators for the purpose of intimidation and control over the victim.1–3 There is no agreement regarding what set of signs, symptoms, or illnesses are considered the standard International Classification of Diseases, 9th Revision, Clinical Modification constellation for a diagnosis of intimate partner violence.4,5

The Centers for Disease Control and Prevention reports that approximately 4.8 million episodes of intimate partner violence occur every year in the United States in women 18 years and older.6 The literature is inconsistent as to whether minorities are at increased risk, with some studies reporting significant differences7–10 and others finding no racial or ethnic differences.11,12 The most recent and largest nationally representative study found no differences in lifetime prevalence of intimate partner violence by race/ethnicity, whereas the rate for the 12 months preceding the survey was almost twice as high among African Americans.13 Although some authors link intimate partner violence to socioeconomically deprived communities, it is by no means limited to the economically disadvantaged. Families with conflicting priorities and stressors associated with limited psycho-social reserves may be at greatest risk.14 Factors including housing conditions, poverty, and street violence are associated with a higher prevalence of violence inside the home environment. Political disenfranchisement and cultural isolation also may be mediators for intimate partner violence. Women living under such conditions are more likely to be victimized as compared with women living in more stable and better organized communities.15–17

Exposure to intimate partner violence is associated with a range of negative psycho-behavioral risks and health outcomes including increased risk of poor physical health, physical disability, psychological distress, mental illness, and heightened substance use including alcohol and illicit drugs.18 Sexual and physical intimate partner violence has been linked significantly with depression, suicidality, and posttraumatic stress disorder.19–22 Women who suffer from intimate partner violence are more likely to have sexually transmitted diseases, vaginal bleeding or infection, and urinary tract infections.23 Abuse during pregnancy has been shown to be associated with significantly higher rates of depression and suicide attempts as well as use of tobacco, alcohol, and illicit drugs.24–31 Intimate partner violence has been linked to both pregnancy complications (eg, inadequate weight gain, infections, and bleeding) and adverse pregnancy outcomes (low birth weight [LBW], preterm delivery, and neonatal death).32–34 Intimate partner violence among minority populations, already at higher risk for poor pregnancy outcomes, may be a significant contributor to the health disparities observed in reproductive outcomes among African-American women.

The objective of this study was to estimate the efficacy of a cognitive behavioral intervention administered as part of a randomized controlled trial (RCT) during prenatal care in reducing the recurrence of intimate partner violence during pregnancy and improving birth outcomes (LBW and preterm delivery) in a population of African-American residents of Washington, DC (DC).

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PARTICIPANTS AND METHODS

The NIH-DC Initiative to Reduce Infant Mortality in Minority Populations is a collaboration between Children's National Medical Center, Georgetown University, George Washington University Medical Center, Howard University, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the National Center on Minority Health and Health Disparities, and RTI International. As part of this collaboration, we conducted an RCT to evaluate the efficacy of an integrated behavioral intervention delivered during prenatal care in reducing cigarette smoking, environmental tobacco smoke exposure, depression, and intimate partner violence during pregnancy and in improving pregnancy outcome. This study was reviewed and approved by the institutional review boards of all participating institutions.

Women were screened at six community-based prenatal care sites serving mainly minority women in DC between July 2001 and October 2003. Women were demographically eligible if they self-identified as being a minority and were at least 18 years old, 28 weeks pregnant or less, a DC resident, and English speaking. Almost two thirds (63.4%) were recruited before 22 weeks of gestation, 16.9% were recruited between 22 and 25 weeks of gestation, and 19.7% were recruited between 26 and 28 weeks of gestation. The women who were demographically eligible went through a two-stage consent and enrollment process. After initial consent, participants were screened for the four risk factors (cigarette smoking, environmental tobacco smoke exposure, depression, and intimate partner violence) using an audio-computer assisted self-interview, which also confirmed their demographic eligibility. An average of 9 days after screening, a baseline interview took place during which more detailed information on socio-demographics, reproductive history, and behavioral risks was collected. After this interview, women were considered to have consented to participate. Follow-up data collection by telephone interviews occurred during the second and third trimesters of pregnancy (22–26 and 34–38 weeks of gestation, respectively) and 8–10 weeks postpartum. Intervention and follow-up activities continued until July 2004. Details are published in El-Khorazaty et al.35

A total of 2,913 women were screened, and 1,398 met the eligibility criteria (Fig. 1). Of these, 85% (n=1,191) consented to participate in a baseline telephone interview before randomization; 1,070 (89.9%) were reached and participated. Eligible women were randomly assigned to the intervention group or the usual care group. Of these women, 1,044 were African-American and still pregnant at the time of the baseline interview. Included in the analyses were 521 randomly assigned to the intervention group and 523 randomly assigned to the usual care group.

Fig. 1
Fig. 1
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Women randomly assigned to the intervention group received an integrated cognitive behavioral intervention, and women randomly assigned to the usual care group received their usual prenatal care as determined by the standard procedures at the prenatal care clinic. A total of 336 women reported intimate partner violence victimization in the past year during the baseline interview, and this group could be categorized further as having minor or severe intimate partner violence or both and physical or sexual intimate partner violence or both based on the Conflict Tactics Scale.36 A woman may experience multiple types of violence; thus, these categories are not mutually exclusive. Minor intimate partner violence was defined as the woman's partner slapping, grabbing, pushing, or shoving her, throwing something at her, twisting her arm or hair, or insisting, without using force, on anal sex, vaginal sex, or sex without using a condom. Major intimate partner violence was defined as the woman's partner kicking, biting, punching, beating up, hitting, choking, or slamming her, using a knife or gun, burning or scalding her on purpose, or using force or threats to have anal or vaginal sex. Physical intimate partner violence was defined as the woman's partner throwing something at her, pushing or shoving her, using a knife or gun, or hitting, choking, slamming, grabbing, burning, or kicking her. Sexual intimate partner violence was defined as the woman's partner forcing sex without using a condom, forcing her to have sex, or threatening or insisting on having sex (oral, anal, or vaginal) against her will.

The intervention used in this RCT was delivered during routine prenatal care visits at the clinics by interventionists (master's level social workers or psychologists) trained specifically to deliver this intervention. The intervention was evidence-based and specific to each of the designated psycho-behavioral risks.37 At each intervention session, the woman identified which of the four risks she was experiencing. The intervention was delivered by the interventionist and targeted to address all risks reported at each session, regardless of previously reported risks. The intervention for intimate partner violence emphasized safety behaviors and was based on the structured intervention developed by Parker and colleagues38 and based on Dutton's39 Empowerment Theory. This intervention provided information about the types of abuse (eg, emotional, physical, and sexual) and the cycle of violence (eg, escalating, intimate partner violence, honeymoon period), a danger assessment component to assess risks, and preventive options women might consider (eg, filing a protection order) as well as the development of a safety plan (eg, leaving important documents and papers with others). In addition, a list of community resources with addresses and phone numbers was provided. The interventions for smoking and environmental tobacco smoke exposure were combined and based on Smoking Cessation or Reduction in Program Treatment (Windsor RA. Counseling smokers in Medicaid maternity care: the SCRIPT project [abstract]. Tob Control 2009;9(suppl):162). This intervention was cognitive–behavioral and based on a woman's stage of readiness for behavioral change.40 The depression intervention was developed by Miranda and Munoz41 based on cognitive behavioral theory and focused on mood management, increasing pleasurable activities, and increasing positive social interactions.

The components of the intervention were designed for delivery in a minimum of four sessions, with eight prenatal sessions required for a complete intervention based on the highest number of sessions required for a specific risk. Fifty-one percent of the women randomly assigned to the intervention group received four or more sessions; one quarter of the women attended no intervention sessions. Individualized counseling sessions provided an integrated approach to multiple risks responsive to a woman's specific risk combination. Two additional postpartum booster sessions were provided to reinforce risk-specific intervention goals and support women through the postpartum period. Intervention sessions were conducted privately in a room proximate to or within the prenatal care clinics and occurred immediately before or after routine prenatal care. Intervention activities addressing all of the individually identified risks at each session lasted for an average of 35±15 minutes. Women in the intervention group received $10 for each intervention session and additional $15 and $25 gift certificates for the first and second postpartum intervention sessions, respectively.

During screening or follow-up, women reporting suicidal ideation were referred immediately to the mental health consultation team. Women were evaluated and referred as necessary. Those found to be potentially suicidal (n=10) were excluded from the study.

The sample size was powered to test the reduction in psycho-behavioral risk, with the theory that a reduction in risk would help improve pregnancy outcomes. Assuming a 5% level of significance, 80% power would allow the detection of 10–20% reductions in risk-specific factors among women in the intervention group from a prevalence of 100% at recruitment. A sample of 1,050 women needed to be retained at the end of the follow-up period (525 women each in the intervention and usual care groups). The anticipated number of women reporting intimate partner violence needed to detect significance in reducing risk was 337 split between the two care groups. This sample size also was sufficient to detect a 25% reduction in preterm birth and LBW combined in the intervention group compared with that for the usual care group (estimated at 20%). Based on a declining birth rate in DC, the recruitment period was extended 4 months to reach the required sample size.

Site- and risk-specific permuted block randomization to the intervention or usual care group was conducted. Both the investigators and the field workers were blinded to block size. A computer-generated randomization scheme was used to consider all the possible risk combinations within each of the recruitment sites. When a woman completed the baseline interview and was ready for randomization, the recruitment staff would call the data-coordinating center, where the participant's assignment was determined.

Validated instruments were used for each of the data-collection time points. During screening, intimate partner violence was identified by the Abuse Assessment Screen, a measure designed and validated for use in pregnancy if a woman reported physical or sexual abuse by a partner in the previous year.42 During the baseline and follow-up interviews, the frequency of physical assault and sexual coercion (partner to self) was measured by the Conflict Tactics Scale.36 A more detailed description of instruments used for other risks is available in Katz et al.37

Telephone interviewers and their supervisors were blinded to the participants' randomization group. Research staff maintained confidentiality when communicating with participants outside the clinic setting. Addresses were collected to facilitate tracing efforts, but the women were informed that they would not receive mail from Project District of Columbia—Healthy Outcomes of Pregnancy. For women experiencing intimate partner violence, staff did not want to raise women's risk for abuse by having them receive mail from the study that might be regarded negatively by an abusive partner or would expose the pregnancy. Women also were asked whether or not telephone messages from project staff could be left on their telephone answering machines. If not, this was noted in the participant's computerized record, which was accessible by all project teams. As financial incentives, the women received $5 for the screening, a 30-minute telephone card for providing main study consent, and $15 for each telephone interview. At the time of recruitment, medical records were abstracted and, on delivery, data on neonatal and pregnancy outcomes were recorded.

To preserve the randomization, participant data were analyzed according to their care-group assignment, regardless of receipt of intervention, using an intent-to-treat approach. All statistical analyses were conducting using SAS 9.1.3 (SAS Institute, Cary, NC). Bivariate analyses were conducted to compare the baseline characteristics and pregnancy outcomes of women assigned to the intervention and usual care groups and to compare women who reported a recurrence of intimate partner violence during pregnancy or postpartum with those who did not. t tests compared groups based on continuous variables (using the TTEST procedure in SAS), and χ2 tests compared the groups with respect to categorical variables (using SAS's FREQ procedure). Logistic regression was used to model recurrence of intimate partner violence based on care-group assignment, controlling for relevant covariates (using the LOGISTIC procedure). Logistic models also were created to predict minor, severe, physical, and sexual intimate partner violence reported at each interview. Adjusted odd ratios were produced by models that included care group plus other covariates.

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RESULTS

Table 1 presents the sociodemographic characteristics and psycho-behavioral risks at baseline between women randomly assigned to the intervention group (n=521) or to the usual care group (n=523). There were no significant differences between these two groups. During the baseline interview, 336 women (32.2%) reported intimate partner violence in the previous year. Of these women, 169 were in the intervention group and 167 were in the usual care group (Fig. 1). In this subgroup, there were no significant differences between the women in the two randomization groups (Table 1). The mean age of the participants was 24.5 years. On average, participants initiated prenatal care at 13 weeks of gestation. Seventy-six percent were single, 68% had at least a high school education, and 79% were enrolled in Medicaid. In this population, 22% of the participants admitted to active smoking during pregnancy, 78% self-identified as being at risk for environmental tobacco smoke exposure, and 62% were depressed as measured by the Hopkins Scale. In addition, 32% admitted to using alcohol, and 17% admitted to illicit drug use during pregnancy.

Table 1
Table 1
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Of those women reporting intimate partner violence at baseline, 306 (91.1%) completed at least one of the follow-up or postpartum interviews. No significant differences were found between those with follow-up data (n=306) and those without (n=30), nor were the women randomly assigned to the intervention group (n=150) significantly different from those randomly assigned to the usual care group (n=156).

Women reporting continued intimate partner violence during pregnancy or postpartum (n=94) were significantly different from those who reported no further episodes of intimate partner violence (n=212) beyond baseline with respect to care group (P=.006), gestational age at baseline (P=.035), alcohol use during pregnancy (P=.014), and depression at baseline (P=.009).

Controlling for these four variables in the logistic regression, only care group, alcohol use, and depression were significant in the reduced model. Logistic regression results for continued intimate partner violence at all interviews during pregnancy and postpartum (n=94) showed that women in the intervention group were less likely to have recurrent episodes of intimate partner violence (adjusted odds ratio [OR] 0.48, 95% confidence interval [CI] 0.29–0.80). Alcohol use during pregnancy measured at baseline and depression were associated with the chance of recurrent episodes of intimate partner violence (adjusted OR 1.85, 95% CI 1.09–3.12 and adjusted OR 1.90, 95% CI 1.11–3.25, respectively). Women in the intervention group were less likely to be victimized by their partners at the first or second follow-up interviews (second or third trimester) (Table 2). Although the trend remains, the difference does not reach significance in the postpartum period.

Table 2
Table 2
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Table 3 presents adjusted ORs and numbers needed to treat for the effect of the intervention on minor intimate partner violence, severe intimate partner violence, physical intimate partner violence, and sexual intimate partner violence at baseline and at each of the follow-up interviews. It should be noted that reported intimate partner violence at baseline refers to the 1 year preceding the interview, whereas, at each of the three subsequent interviews, the reference period was since the previous interview (on average 9–10 weeks during pregnancy and 14 weeks between the second follow-up and the postpartum interview). At baseline, no significant differences between groups were observed for any of these four categories. Women with minor intimate partner violence who were randomly assigned to the intervention group were significantly less likely to experience further episodes at all of the follow-up points. Women categorized with severe intimate partner violence in the intervention group showed a significantly reduced incidence of episodes postpartum compared with those in the usual care group. Women experiencing physical intimate partner violence in the intervention group were significantly less likely to experience episodes at first follow-up or at postpartum interviews compared with those in the usual care group. For women experiencing sexual intimate partner violence, the intervention did not significantly reduce their incidence of episodes at any follow-up visit during pregnancy or postpartum.

Table 3
Table 3
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For women experiencing intimate partner violence victimization throughout pregnancy and postpartum, Table 4 presents a comparison of women in the intervention and usual care groups with respect to various adverse pregnancy outcomes. The results indicate that rates of LBW (less than 2,500 g) were not different in the two groups (intervention: 12.8%, usual care: 18.5%, P=.204) and that rates of very low birth weight (VLBW) (less than 1,500 g) were lower among women in the intervention group (intervention: 0.8%, usual care: 4.6%, P=.052). In addition, rates of preterm births (37 weeks of gestation) were not statistically different in the two groups (13.0% compared with 19.7%, P=.135). However, the two groups of women were significantly different with respect to very preterm delivery (less than 33 weeks of gestation) (1.5% compared with 6.6%, P=.030). Also, the two groups were significantly different for mean gestational age at delivery (38.2 weeks compared with 36.9 weeks, P=.016).

Table 4
Table 4
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DISCUSSION

This study evaluates the efficacy of a psycho-behavioral intervention during prenatal and postpartum care on the reduction of intimate partner violence recurrence and improved pregnancy outcomes in African-American women reporting intimate partner violence victimization. We were able to recruit 336 women acknowledging intimate partner violence victimization within the past year during the baseline interview and who were willing to participate in the intervention. In addition, 91% of these women continued to participate in this randomized trial during pregnancy, postpartum, or both pregnancy and postpartum. This finding emphasizes the relative ease of recruitment of high-risk African-American women to intimate partner violence–reduction programs in the prenatal care setting. The recruitment staff were trained to be culturally sensitive, and the screening tool was both simple and administered confidentially. These women are also willing to maintain participation in a program that provided cognitive behavioral strategies relevant to psycho-behavioral problems they experienced during pregnancy.

The integrated intervention provided women with suggestions to deal with depression and tobacco exposure in addition to strategies aimed at reducing the risk of intimate partner violence. Alternative explanations for our findings were considered. For other services for which we queried the women, there were no differences between women experiencing intimate partner violence and those not. We also considered whether women's previous reproductive history might explain why the intervention group had significantly better outcomes. None of the factors (previous preterm delivery, previous miscarriage, previous stillbirth, number of previous voluntary interruptions of pregnancy) that might predict poor reproductive outcomes were different between the two care groups. Finally we considered whether medical conditions that might influence pregnancy outcomes (preconception and gestational diabetes, chronic and gestational hypertension, sexually transmitted infections) were significantly different between the two care groups. None of these medical conditions were significantly different between the two care groups.

The American College of Obstetricians and Gynecologists identifies the response to domestic violence against women as a priority and recommends screening within primary care settings.43 They also recommend the Patient Health Questionnaire as a screening instrument for intimate partner violence, depression, and anxiety. This questionnaire recognizes the co-occurrence of these psycho-social risks, and it screens for substance exposure known to occur more frequently in victims of intimate partner violence.24–27,31 The findings of our study confirm the importance of emphasizing a more global approach to risk assessment and service provision in this population of high-risk African-American women.

Intimate partner violence has been associated with poor pregnancy outcomes in the literature.28,30,32–34,44–47 Our study found reductions in adverse pregnancy outcomes despite previous evidence of associations between intimate partner violence during pregnancy and LBW.28,30,32–34 The intervention model targeting multiple risk factors in African-American women suffering from intimate partner violence victimization shows promising results that could be translated into reduction of neonatal mortality within that population. The current literature agrees that very preterm neonates make up more than 90% of the overall infant mortality rate among preterm infants.48 The intervention affected multiple pregnancy outcomes, especially those with the highest level of neonatal risk—VLBW and very preterm delivery. The significant reduction of VLBW and very preterm delivery in our intervention group may have important implications for reducing the rates of poor pregnancy outcomes and infant mortality among African-Americans.

Whether or not our analyses were adjusted for alcohol use and depression, the intervention universally reduced minor intimate partner violence during pregnancy and postpartum. It is important to recognize that the classification of minor intimate partner violence on the Conflict Tactics Scale includes acts of assault such as slapping, grabbing, pushing, and shoving as well as twisting of the arm or hair. Although such actions may be considered minor on the Conflict Tactics Scale, they are significant acts of aggression and violence. The intervention was unable to affect more severe acts, described as using a knife or gun, choking, burning, scalding, or kicking. The lack of effect on sexual intimate partner violence could be attributed to the reluctance or discomfort of the study participants to divulge or discuss these topics. The intervention team was instructed to show sensitivity to the level of comfort of the study participants in this domain. The intervention as designed and implemented reduced only the recurrence of minor and physical intimate partner violence, but it could have reduced other associated risks.

The effect of intimate partner violence on pregnancy outcome is complicated by its co-occurrence with depression and alcohol use.47,49–51 The behavioral intervention for depression could have contributed significantly to our success. Among the women reporting intimate partner violence at baseline, 62% reported being depressed and 32% reported alcohol use during pregnancy. Addressing intimate partner violence and depression together may have helped women implement suggested strategies to assess risks, consider preventive options, and develop safety plans. We also detected a significant association between intimate partner violence and illicit drug use (16.7%) and active smoking (22%), both known to be risks for preterm delivery and LBW.52,53 In reduced logistical models, alcohol use during pregnancy and depression measured at baseline continued to exert a significant influence on perpetuating intimate partner violence during pregnancy and postpartum. This describes a cycle where co-occurring risk factors are immutably entangled.

A limitation of the study was that it was not powered to test the efficacy of the intervention with respect to adverse pregnancy outcomes but rather resolution of the psycho-behavioral risks. Women were invested only modestly in participating in the intervention. Despite the fact that we were able to deliver the minimum number of intervention sessions to 59% of participants with intimate partner violence, women randomly assigned to the intervention group were successful in risk reduction. These rates of participation may be a reflection of difficult life circumstances among poor urban women. These women encountered other behavioral challenges during pregnancy, such as alcohol and drug use, that were not addressed by the intervention. Had we addressed these, we might have been even more successful. The intervention effect(s) we found may apply only to high-risk minority pregnant women. It would be important to test this intervention in other racial or sociodemographic groups to confirm generalizability. Larger studies testing the effectiveness of implementing such interventions in community-based clinics providing prenatal care could have important health-policy implications.

There is evidence that this intervention for pregnant African-American women reduced intimate partner violence victimization during pregnancy and improved pregnancy outcome. If generalizable, our results should encourage health care providers and third party payers to go beyond screening for psycho-social and behavioral risks to providing services during prenatal care to address such risks. The potential cost savings associated with reduction of births within the highest risk category may be substantial.

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Figure. No caption availble.


© 2010 by The American College of Obstetricians and Gynecologists.

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