Obstetrics & Gynecology

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Obstetrics & Gynecology:
doi: 10.1097/01.AOG.0000143826.38439.af
Original Research

Hormone Therapy Prescribing Patterns in the United States

Buist, Diana S. M. PhD*†; Newton, Katherine M. PhD*†; Miglioretti, Diana L. PhD*†; Beverly, Kevin MA*; Connelly, Maureen T. MD, MPH‡; Andrade, Susan ScD§; Hartsfield, Cynthia L. PhD¶; Wei, Feifei PhD∥; Chan, K Arnold MD, ScD**††; Kessler, Larry ScD‡‡

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Author Information

From the *Center for Health Studies, Group Health Cooperative, Seattle, Washington; †University of Washington, School of Public Health and Community Medicine, Seattle, Washington; ‡Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care; Harvard Medical School and Menopause Consultation Service and Harvard Vanguard Medical Associates, Boston, Massachusetts; §Meyers Primary Care Institute, Worcester, Massachusetts; ¶Kaiser Permanente, Denver, Colorado; ∥Health Partners Research Foundation, Minneapolis, Minnesota; **Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; ††Health Maintenance Organization Research Network Center for Education and Research on Therapeutics; and ‡‡Office of Science and Technology, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Rockville, Maryland.

Funded by a cooperative agreement from the National Cancer Institute (U19-CA-79689-05). Dr. Buist's time was supported in part by a grant from the American Cancer Society (CRTG-03–024–01-CCE).

Data collection for the Patient Safety Project was funded by a grant from the Agency for Healthcare Research and Quality (AH RQ U18HS11843-01).

The authors thank Parker Pettus and all of the programmers from participating sites who worked on the Health Maintenance Organization's Research Network Center for Education and Research on Therapeutics Patient Safety Project (Julia Hecht, phd, Group Health Cooperative; Doris Milan, Harvard Pilgrim; Jackie C. Fuller, Meyers Primary Care Institute; David L. McClure, ms, Kaiser Permanente Colorado; and Gerald Amundson, HealthPartners).

Address reprint requests to: Diana S. M. Buist, PhD, MPH, Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle, WA 98101; e-mail: buist.d@ghc.org.

Received May 19, 2004. Received in revised form July 16, 2004. Accepted July 28, 2004.

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OBJECTIVE: We sought to examine prescribing patterns (prevalence and rates of initiation and discontinuation) for estrogen plus progestin (hormone therapy [HT] and estrogen alone [ET]) in the United States in the 2 years before the published results of Women's Health Initiative's (WHI) HT trial's early termination and for 5 months after their release.

METHODS: We conducted an observational cohort study of 169,586 women aged 40–80 years who were enrolled in 5 health maintenance organizations in the United States to estimate the prevalence of HT and ET and discontinuation and initiation rates between September 1, 1999, to June 31, 2002 (baseline), and December 31, 2002 (follow-up). We used automated pharmacy data to identify all oral and transdermal estrogen and progestin dispensed during the study period.

RESULTS: The prevalence of HT declined 46% from baseline to follow-up (14.6% to 7.9%); ET use declined 28% during the same period (12.6% to 9.1%). The discontinuation of HT increased almost immediately, from 2.5% at baseline to 13.8% in October 2002. We saw an immediate decrease in HT and ET initiation rates, from 0.4% and 0.3% at baseline, respectively, to 0.2% for HT and ET at follow-up.

CONCLUSION: The diffusion of the WHI HT trial results had an immediate impact on the discontinuation of HT and ET and is likely responsible for the 46% and 28% decline in the initiation of these respective therapies. Further exploration of why women continue to use HT and identification of methods for addressing reasons for continued use are indicated.


Combined estrogen and progestin therapy (HT) and estrogen-only therapy (ET) have been used widely by peri- and postmenopausal women for more than 40 years to manage menopausal symptoms and, more recently, for the prevention of osteoporosis and coronary heart disease (CHD).1 The vast majority of observational evidence has suggested that HT and ET reduce the incidence of CHD,2–5 bone fractures,6,7 and colorectal cancer8,9 in postmenopausal women. In the mid-1990s, an estimated 38% of postmenopausal women in the United States used HT or ET.1

The Women's Health Initiative (WHI) was designed to examine the risks and benefits of HT, ET, and diet on heart disease, bone fractures, and breast and colorectal cancer in predominantly healthy postmenopausal women.10 On May 31, 2002, the Data and Safety Monitoring Board stopped the WHI HT randomized trial (HT versus placebo for women with an intact uterus) after an average of 5.2 years of follow-up (2.5 years early) because the risks of HT were found to outweigh the benefits.11 Women who were assigned randomly to HT experienced an excess risk of invasive breast cancer, CHD, stroke, venous thromboembolism, and pulmonary embolism compared with women who were assigned randomly to placebo. The use of HT was associated with a reduced risk of colorectal cancer11 and bone fractures.12 The HT trial early-termination results were released to the general public and scientific community on July 9, 2002.11 The trial of ET for women who had hysterectomies before study enrollment also ended early, on March 4, 2004, after nearly 7 years of follow-up because there was no overall benefit on disease outcomes among women assigned randomly to ET compared with placebo.13 The observational trial of low-fat diet and calcium and vitamin D supplementation is still ongoing.

In 1998, the Heart and Estrogen and Progestin Replacement Study randomized trial14 reported no protective effect of HT among women with a previous history of coronary disease and an excess risk of coronary disease among HT users during the first year of exposure. The findings of this trial and the early termination of the WHI HT trial have led experts to conclude that HT should be used only for short-term therapy for the relief of menopausal symptoms and for the prevention of bone fractures in selected women.15,16

Using national pharmacy sales data, Hersh et al17 estimated a 38% decline in HT and ET dispensing after the termination of the WHI HT trial. However, these data did not have woman-level information and, therefore, could not be used to estimate hormone discontinuation and initiation rates. Our current observational cohort study examined woman-level data from 5 health maintenance organizations in the United States to estimate overall and age-specific prevalence of HT and ET (proportion of women using hormones in the study population) and rates of discontinuation (rate of discontinuation of hormone use among hormone users) and initiation (rate of initiation of hormones among women who do not use hormones) in the 2 years before the published results of the WHI HT trial and for 5 months after their release.

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This study was conducted within the Cancer Research Network, a consortium of nonprofit health maintenance organizations. Our observational cohort study takes advantage of the Health Maintenance Organization's Research Network's Center for Education and Research on Therapeutics18 Patient Safety Cohort to examine patterns of HT and ET use before and after the release of the WHI HT trial results (July 2002). The Patient Safety Cohort consists of a random sample of approximately 200,000 men and women of any age who were enrolled at each of 10 participating health maintenance organizations. The study population was constructed to give equal weight to each health maintenance organization and to maintain confidentiality of the participating health maintenance organizations. Patients were eligible for inclusion if they had a pharmacy prescription benefit at any time during the study period (January 1, 1999, to June 20, 2001). This study was reviewed and approved by human subjects committees from each participating institution.

We extended the period of observation for the Patient Safety Cohort through December 31, 2002. From the original sample, we constructed a dynamic cohort of 169,586 women aged 40–80 years from 5 health maintenance organizations: Group Health Cooperative, Seattle, Washington; Harvard Pilgrim Health Care, Boston, Massachusetts; Fallon Community Health Plan, Worcester, Massachusetts; Kaiser Permanente Colorado, Denver, Colorado; and Health Partners, Minneapolis, Minnesota.

We used automated pharmacy dispensing data to estimate the prevalence of HT and ET and incidence of discontinuation and initiation. Two of the study researchers (K.M.N. and M.T.C.) reviewed a list of National Drug Codes of all oral or transdermal estrogen or progestin dispensings to identify hormones used in peri- and postmenopausal women. We did not include prescriptions for vaginal or compounded estrogens in these analyses.

Users of HT included women who received combination products or estrogen preparations with at least 1 dispensing for a progestin product. Users of ET included women who received estrogen preparations with no progestin dispensing. Progestin use was considered current for all estrogen prescriptions if there was any progestin-containing prescription dispensing during the study period, or if the prescription was for combination products.

We collected information on the highest daily conjugated equine estrogen dose dispensed in each month and organized these into the following categories: less than 0.625 mg, 0.625 mg, or more than 0.625 mg conjugated equine estrogen equivalents. We classified oral estradiol into conjugated equine estrogens as follows: less than 1.0 mg = less than 0.625 mg conjugated equine estrogen; 1.0 mg = 0.625 mg conjugated equine estrogen; and more than 1 mg = more than 0.625 mg conjugated equine estrogen.19,20 The relative equivalence was established for transdermal estradiol as follows: 0.05 mg = 0.625 mg conjugated equine estrogen; more than 0.05 mg = more than 0.625 mg conjugated equine estrogen; and less than 0.05 mg = less than 0.625 mg conjugated equine estrogen.19,20

The intended duration of each dispensing and, thus, the run-out date, was established using automated data on number of estrogen pills or patches dispensed. A woman was considered a user in any month she received at least one estrogen dispensing. We considered women to be continuous users as long as the hormone was dispensed within 60 days of the run-out date. A new run-out date was set with each successive dispensing rather than using cumulative number of pills from all dispensings.

We used automated membership data to track subjects’ enrollment in a health maintenance organization for each month. We considered women to be enrolled in the health plan until there was a lapse in membership of more than 2 months. We deleted (censored) women from the analyses at their date of disenrollment from the health maintenance organization; however, women rejoined the analysis if they reenrolled in a health maintenance organization during the study period.

We excluded the initial 7 months of data (at study start and/or after re-enrollment) for subjects to allow a sufficient run-in time for estimation of initiation rates. We examined plots of initiation and discontinuation over the course of time, and the trends were stable before June 2002 relative to the change after the release of WHI. Therefore, we pooled all the baseline data (September 1999 to June 2002) to increase the precision of the baseline estimates and generated mean monthly values. We examined ET and HT separately for all analyses.

We used log-binomial regression21 to model the incidence of initiation and discontinuation of HT and ET at baseline and for each month after June 2002, adjusting for age and health maintenance organization. We used a transition model,22 assuming a first-order Markov process, to account for the serial correlation within women that resulted from having repeated measurements on each woman. We modeled HT and ET use conditional on use/no use in the previous month, which is equivalent to modeling the incidence of initiation (use in 1 month given no use in the previous month) and discontinuation (no use in 1 month given use in the previous month). We report the relative risk and corresponding 95% confidence intervals comparing the incidence of initiation and discontinuation July 2002 through December 2002 to the baseline incidence. We also stratified the results by age group.

Age was calculated at each study month. Women contributed information for each age group they belonged to during the study period for the age-specific prevalence estimates. All analyses were conducted in SAS 8.2 (SAS Institute, Cary, NC).

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There was a 12% decrease (n = 19,979) in the study population during the 39-month study period (approximately 512 per month) as the result of women aging out of the cohort, disenrollment from their health maintenance organization, or death (Table 1). Individual health maintenance organizations contributed 17.8–21.3% of the study population (data not shown). Women aged 40–49 years comprised 38% of the cohort at baseline and 34% at follow-up. We observed a small increase between baseline and follow-up in the proportion of women aged 50–59 years (29–31%) and aged 70–79 years (15–17%). The overall prevalence of hormone use was 27.2% at baseline, or 14.6% HT and 12.6% ET (Table 2). We found a 45.9% and a 27.8% reduction in the prevalence of HT and ET, respectively, after July 2002. Nearly all estrogen users received 0.625 mg of conjugated equine estrogen or its equivalent. Just more than 80% of HT and ET users took 0.625 mg conjugated equine estrogen or the equivalent at baseline; this decreased to 73.1% after July 2002. We observed a 43.7% and 18.9% decrease in the prevalence of 0.625 mg and more than 0.625 mg conjugated equine estrogen or its equivalent after July 2002, respectively, and a 5.8% increase in less than 0.625 mg use.

Table 1
Table 1
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Table 2
Table 2
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The discontinuation rates of HT increased from July 2002 to October 2002 and then stabilized or declined (Fig. 1; P < .001); this increase translated into a 5.52 higher risk of discontinuation (95% confidence interval 5.30–5.75) in October 2002 compared with baseline (P < .001; Table 3). The same trend was observed for the discontinuation of ET, although the rise in rates were not as marked (P = .001; Fig. 1). There was a significant decrease in initiation of HT and ET for all months compared with baseline (P < .001), but there was no clear trend by month. The decrease in initiation rates was greater among HT users than ET users.

Table 3
Table 3
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Fig. 1
Fig. 1
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The prevalence of HT was highest in women approximately 55 years of age and lowest at the extremes of younger and older age (Fig. 2). We saw a similar distribution of HT use by age during follow-up, but with a much lower prevalence across age groups. We noted a 27% decline in HT prevalence among women aged 40–44 years, a 40–50% decline in prevalence between women aged 45–65 years, and a 50–53% decline in prevalence among women aged 65–79 years.

Fig. 2
Fig. 2
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The distribution of ET prevalence was lowest at the youngest ages and highest between women aged 59–66 years (Fig. 3). Unlike HT, the higher rate of ET use was sustained well into a woman's 70s before and after July 2002. There was less variation in the decline of ET prevalence by age than HT, with decreases ranging from 21% among women aged 65–69 years to 29% among women aged 50–54 years.

Fig. 3
Fig. 3
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Less than 1% (0.38%) of women initiated HT per month at baseline, with the lowest proportion of initiation among women aged 40–44 years (0.09%) and the highest proportion among women aged 50–54 years (0.81%; rate data not shown). The proportion of women initiating HT was considerably lower in December 2002 (0.18% per month) than before July 2002 (P < .001), with the greatest proportion among women aged 55–59 years (0.41%; P < .001). The initiation of ET was lower than HT, with 0.28% of the cohort initiating per month before July 2002; this decreased to 0.23% after July 2002 (P < .001). Women aged 60–69 years were most likely to initiate ET before (0.44% per month) and after July 2002 (0.39%; P = .25).

Relative risks for the discontinuation of HT after July 2002 varied markedly by age; most discontinuation occurred in women aged 55–79 years, with a 5- to 6-fold increase in discontinuation rates compared with baseline rates (P < .001; Table 4). There was virtually no change in discontinuation in women aged 40–44 years (P = .90). We also observed an increase in ET discontinuation rates after July 2002 among women age 45 years or older (2- to 3-fold increase; P < .001). No linear trend in rates of ET (P = .75) or HT (P = .53) initiation by age was noted. However, we did observe twice the decline in HT initiation among the youngest and oldest women compared with women aged 55–59 years (P < .001).

Table 4
Table 4
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Geographic diversity existed in the prevalence of HT and ET use in our cohort. The ranges of HT prevalence among health maintenance organizations were 10.2–17.1% at baseline and 4.0–10.5% at follow-up (data not shown). The prevalence of ET among health maintenance organizations ranged from 7.7% to 21.0% at baseline and 4.6% to 17% at follow-up. The same health maintenance organizations were at the same ends of the ranges for ET and HT at baseline and follow-up. We found a decrease in the prevalence of HT and ET of 46% (range 38.6–60.8%) and 28% (range 21.0–43.2%), respectively, by December 2002.

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The evidence from the WHI HT trial has made it increasingly clear that the risks of using HT outweigh the benefits for women without menopausal symptoms. Our results showing an immediate reduction in HT and ET use after the termination of the WHI HT trial are supported by self-reported data from other cohorts23,24 and national pharmacy sales.17 Recent estimates of overall hormone cessation after July 2002 have ranged from 38%17 to 58%.24 There was a 37% overall decline in HT and ET use from baseline to December 2002 in our large, geographically diverse sample of women aged 40–80 years; HT prevalence declined 46% (14.6% to 7.9%) and ET declined 28% (12.6% to 9.1%). Our woman-level data most closely mirror estimates from national pharmaceutical sales data17 and reported rates of decline in Premarin (Wyeth, Philadelphia, PA) sales (Colata G. Rush to fill void in menopause-drug market. New York Times, September 1, 2002). The 2 studies reporting higher rates of discontinuation used a definition that likely overestimates true rates because they defined discontinuation as attempting to stop (stopping hormones for ≥ 1 week or reducing estrogen dosage).23,24

Other studies have found that additional information needs to be relayed to the lay public about the risks of continued HT use.23,24 In a recent study of 670 HT and ET users aged 50–69 years,23 nearly all women (93%) reported some awareness of the WHI HT trial findings, yet only 23% of women had correct knowledge of the findings. In that cohort, most of the HT users (69%) and some of the ET users (37%) attempted to stop using their hormones within the 6–8 months after July 2002.23 Among the women who attempted to stop, 74% were successful.25 We do not know whether improving knowledge of HT risks and benefits would further decrease the use of HT. Knowledge about HT was associated with successfully stopping hormones in bivariable models but was not identified as a strong predictor in multivariable models, most likely because having troublesome withdrawal symptoms was so strongly associated with women's ability to stop.25 A striking finding in our study and those cited previously is the high discontinuation rates among ET users despite the fact that the WHI ET trial was ongoing during the study period. Whether the discontinuation of ET reflects women and providers misunderstanding of the results of the trial, a generalization of the HT findings to ET, or another explanation entirely requires further investigation.

Hersh et al17 were able to link prescription sales with physician office visit information to examine indications for hormone use. Control of menopausal symptoms was indicated by 90% of the physicians who prescribed hormones after July 2002; disease prevention was noted by 5% of physicians (4% for osteoporosis and 1% for cardiovascular disease).17 We did not have information on indication for use, which might contribute to continued use (eg, osteoporosis) or discontinuation (eg, history of coronary artery disease) among our cohort. However, we know that menopausal symptoms are a major reason for initiating ET and HT24,25 and also are the strongest predictor of not being able to stop.25 Approximately 15% of postmenopausal women have symptoms 7 years after menopause.26 We saw a decrease in use of the standard conjugated equine estrogen dose (0.625 mg) among our cohort, a finding that also was supported from national pharmacy sales data.17 Convincing data suggest that less than 0.625 mg of conjugated equine estrogen is adequate for most women to help manage menopausal symptoms.27 A shift toward reducing conjugated equine estrogen dose is not supported by the WHI HT trial results because WHI only evaluated a single dose of HT. Therefore, understanding why women and clinicians are adopting lower doses requires additional exploration. Given the hint of a plateau in discontinuation rates by the end of 2002, it is possible that further reduction in HT and ET use will only occur when effective and safe alternative therapies for controlling menopausal symptoms are available.

Collaborative agreements prevent us from providing site-specific estimates. We observed a greater range in ET prevalence estimates between sites at baseline and follow-up compared with HT, even after adjustment for age. Some of the variation in estimates might be attributed to different prescribing practices by health maintenance organization or, alternatively, to geographic variation in the prevalence of hysterectomies. Importantly, the differences we noted in the prevalence of HT and ET by region did not directly mirror previously published patterns.1 Geographic variation may account for some of the differences in our results compared with findings from New Zealand24 and Northern California.23

There are several strengths of this study. We were able to use woman-level data from a large representative sample of health maintenance organization enrollees between 40 and 80 years of age from 5 geographic sites in the United States. The reported prevalence estimates may be slight overestimates of hormone use in the United States because health maintenance organization members largely have prescription drug benefits and are believed to be wealthier and better educated than the general U.S. population. However, our findings should be generalizable to the approximately 1 in 4 U.S. residents (26.4%) enrolled in health maintenance organizations in the United States,28 if not to the larger U.S. population. We were able to estimate prevalence from pharmacy dispensings rather than from self-reported data or from written prescriptions that may not have been filled. We also were able to censor the first 7 months of data to ensure we had adequate information to estimate true incidence rates for initiation.

Despite the strengths of administrative pharmacy data, it is possible we have missed some HT and ET users. We were unable to capture hormone use in our data set if women did not fill their prescriptions at their health maintenance organization's pharmacies. However, at 1 of the participating health maintenance organizations, 95% of women aged 60 years or older reported filling all or almost all their prescriptions at their health maintenance organization's pharmacies.29 Women also may have switched from oral estrogens to vaginal or compound estrogens, which were not included in these analyses.

We are confident that women who received multiple dispensings of estrogen were using their prescription drugs. However, women with hormone dispensings may not necessarily have used the complete amount; therefore, estimates of exposure may be higher than actual use. Our previous work has found that some women fill hormone prescriptions erratically—it is unknown whether erratic use is to contain cost, decrease dose, or for some other reason. The best way to minimize misclassification of current hormone use is to allow a lag-time beyond the prescription run-out.30 We used a 60-day lag-time to ensure we captured users who were not taking their hormones exactly as prescribed. Our lag-time effectively captured women who may have been using different methods for tapering their medication. We may have underestimated true discontinuation rates during the first 2–3 months after July 2002 given the variability in actual dosing. Despite this, we still saw a rapid decline in use by study month with a peak in October 2002, only 2.5 months after the termination of the WHI HT trial.

More detailed articles have been published since the initial WHI HT trial findings.12,31–35 There may be an additional impact on use resulting from the release of the black box warnings on Prempro (Wyeth, Philadelphia, PA)36 and Premarin (Wyeth)37 in January 2003. Whether the subsequent WHI reports and new black-box labels have further contributed to declines in HT and ET use requires additional analyses beyond the scope of our data collection.

The diffusion of the WHI HT trial results had an immediate impact on HT and ET discontinuation and is likely responsible for the 46% and 28% decline, respectively, in initiation of these therapies. However, substantial HT use still exists among women who are likely not using HT for short-term therapy for the relief of menopausal symptoms. Long-term HT use has important public health consequences. There are an estimated 57.6 million women aged 40–80 years in the United States.38 Applying age-specific HT prevalence estimates from our cohort reveals that as many as 4.3 million women aged 40–80 years in the United States may still be using HT. If we apply our HT prevalence estimates to observed rates from the WHI HT trial,11 we could expect 8,167 additional adverse events per year attributable to HT use given the risks (CHD; stroke; pulmonary emboli; hip fracture; breast or endometrial cancer; or deaths) and benefits (colorectal cancer) of HT. Although admittedly crude, these estimates give a flavor for the potential magnitude of the effect of continued HT use in the United States. Further exploration of why women continue to use HT and identification of alternative methods for addressing those reasons for continued use are indicated.

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Canadian Journal of Information and Library Science-Revue Canadienne Des Sciences De L Information Et De Bibliotheconomie, 31(): 209-231.

Pharmacological Research
Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan (TM)) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells
Cosentino, M; Marino, F; Ferrari, M; Rasini, E; Bombelli, R; Luini, A; Legnaro, M; Delle Canne, MG; Luzzani, M; Crema, F; Paracchini, S; Lecchini, S
Pharmacological Research, 56(2): 140-147.
The medical management of menopause: A four-country comparison care in urban areas
Sievert, LL; Saliba, M; Reher, D; Sahel, A; Hoyer, D; Deeb, M; Obermeyer, CM
Maturitas, 59(1): 7-21.
Women & Health
Physicians' and Women's Views on Hormone Therapy and Breast Cancer Risk After the WHI: A Qualitative Study
Nekhlyudov, L; Bush, T; Bonomi, AE; Ludman, EJ; Newton, KM
Women & Health, 49(4): 280-293.
Estrogen replacement therapy after endometrial cancer: a survey of physicians' prescribing practice
Hancke, K; Foeldi, M; Zahradnik, HP; Gitsch, G; Gilbert, L; Denschlag, D
Climacteric, 13(3): 271-277.
Pharmacoepidemiology and Drug Safety
Hormone therapy and fatal breast cancer
Norman, SA; Weber, AL; Localio, AR; Marchbanks, PA; Ursin, G; Strom, BL; Weiss, LK; Burkman, RT; Bernstein, L; Deapen, DM; Folger, SG; Simon, MS; Nadel, MR
Pharmacoepidemiology and Drug Safety, 19(5): 440-447.
Cancer Epidemiology Biomarkers & Prevention
Changes in breast cancer incidence rates in the united states by histologic subtype and race/ethnicity, 1995 to 2004
Li, CI; Daling, JR
Cancer Epidemiology Biomarkers & Prevention, 16(): 2773-2780.
Bmc Public Health
Adverse childhood experiences and prescription drug use in a cohort study of adult HMO patients
Anda, RF; Brown, DW; Felitti, VJ; Dube, SR; Giles, WH
Bmc Public Health, 8(): -.
ARTN 198
Cancer Causes & Control
Screening mammography intervals among postmenopausal hormone therapy users and nonusers
Onega, T; MacKenzie, T; Weiss, J; Goodrich, M; Titus-Ernstoff, L
Cancer Causes & Control, 21(1): 147-152.
Journal of General Internal Medicine
Changes in newspaper coverage about hormone therapy with the release of new medical evidence
Haas, JS; Geller, B; Miglioretti, DL; Buist, DSM; Nelson, DE; Kerlikowske, K; Carney, PA; Breslau, ES; Dash, S; Canales, MK; Barbash, RB
Journal of General Internal Medicine, 21(4): 304-309.
Acta Obstetricia Et Gynecologica Scandinavica
Hormone replacement therapy and ovarian cancer risk - any news?
Riman, T
Acta Obstetricia Et Gynecologica Scandinavica, 86(9): 1032-1034.
Revue D Epidemiologie Et De Sante Publique
Did the decrease in use of menopausal hormone therapy induce a decrease in the incidence of breast cancer in France (and elsewhere)?
Ringa, V; Fournier, A
Revue D Epidemiologie Et De Sante Publique, 56(5): 297-301.
Neurodegenerative Diseases
Oophorectomy, Menopause, Estrogen, and Cognitive Aging: The Timing Hypothesis
Rocca, WA; Grossardt, BR; Shuster, LT
Neurodegenerative Diseases, 7(): 163-166.
Cancer Causes & Control
Interactions between body mass index and hormone therapy and postmenopausal breast cancer risk (United States)
Li, CI; Malone, KE; Daling, JR
Cancer Causes & Control, 17(5): 695-703.
Preventive Medicine
Women's use of hormone therapy before and after the Women's Health Initiative: A psychosocial model of stability and change
Gerend, MA; Aiken, LS; Erchull, MJ; Lapin, A
Preventive Medicine, 43(3): 158-164.
Archives of Gynecology and Obstetrics
Long-term impact of the women's health initiative on HRT
Parente, L; Uyehara, C; Larsen, W; Whitcomb, B; Farley, J
Archives of Gynecology and Obstetrics, 277(3): 219-224.
Journal of Managed Care Pharmacy
Evolving issues in the clinical and managed care settings on the management of menopause following the women's health initiative
Lukes, A
Journal of Managed Care Pharmacy, 14(3): S7-S13.

Annals of Pharmacotherapy
Use of Hormone Replacement Therapy, 1998-2007: Sustained Impact of the Women's Health Initiative Findings
Silverman, BG; Kokia, ES
Annals of Pharmacotherapy, 43(2): 251-258.
Use of hormone replacement therapy in the Hong Kong public health sector after the Women's Health Initiative trial
Leung, KY; Ling, M; Tang, GWK
Maturitas, 52(): 277-285.
The influence of published studies and position papers on the prescription of peri- and post-menopausal hormone therapy
Heitmann, C; Janhsen, K; Glaeske, G
Gesundheitswesen, 69(7): 379-384.
Changes of menopausal hormone therapy use pattern since 2000: results of the Berlin Spandau Longitudinal Health Study
Du, Y; Scheidt-Nave, C; Rosario, AS; Ellert, U; Doren, M; Knopf, H
Climacteric, 12(4): 329-340.
Changes in women's attitudes towards and use of hormone therapy after HERS and WHI
Hoffmann, M; Hammar, M; Kjellgren, KI; Lindh-Astrand, L; Brynhildsen, J
Maturitas, 52(1): 11-17.
A midpoint assessment of the American Cancer Society challenge goal to halve the US cancer mortality rates between the years 1990 and 2015
Byers, T; Barrera, E; Fontham, ETH; Newman, LA; Runowicz, CD; Sener, SF; Thun, MJ; Winborn, S; Wender, RC
Cancer, 107(2): 396-405.
Cancer Epidemiology Biomarkers & Prevention
Physical activity and colon cancer risk among women in the california teachers study
Mai, PL; Sullivan-Halley, J; Ursin, G; Stram, DO; Deapen, D; Villaluna, D; Horn-Ross, PL; Clarke, CA; Reynolds, P; Ross, RK; West, DW; Anton-Culver, H; Ziogas, A; Bernstein, L
Cancer Epidemiology Biomarkers & Prevention, 16(3): 517-525.
Journal of the National Cancer Institute
Breast cancer trends: A marriage between clinical trial evidence and epidemiology
Berry, DA; Ravdin, PM
Journal of the National Cancer Institute, 99(): 1139-1141.
Breast Cancer Research
Recent breast cancer trends among Asian/Pacific Islander, Hispanic, and African-American women in the US: changes by tumor subtype
Hausauer, AK; Keegan, THM; Chang, ET; Clarke, CA
Breast Cancer Research, 9(6): -.
Ca-A Cancer Journal for Clinicians
A midpoint assessment of the American cancer soociety challenge goal to decrease cancer incidence by 25% between 1992 and 2015
Sedio, RL; Byers, T; Barrera, E; Cohen, C; Fontham, ETH; Newinan, LA; Runowicz, CD; Thorson, AG; Thun, MJ; Ward, E; Wender, RC; Eyre, H
Ca-A Cancer Journal for Clinicians, 57(6): 326-340.
Breast Cancer Research and Treatment
Breast cancer recurrence risk in relation to antidepressant use after diagnosis
Chubak, J; Buist, DSM; Boudreau, DM; Rossing, MA; Lumley, T; Weiss, NS
Breast Cancer Research and Treatment, 112(1): 123-132.
Jognn-Journal of Obstetric Gynecologic and Neonatal Nursing
Complementary and Alternative Medicine Use for Vasomotor Symptoms Among Women Who Have Discontinued Hormone Therapy
Kupferer, EM; Dormire, SL; Becker, H
Jognn-Journal of Obstetric Gynecologic and Neonatal Nursing, 38(1): 50-59.
Current patient perceptions on the menopause: a South African perspective
Smith, AJ; Hall, DR; Grove, D
Climacteric, 8(4): 327-332.
Pharmacoepidemiology and Drug Safety
Reliability of Group Health Cooperative automated pharmacy data by drug benefit status
Boudreau, DM; Doescher, MP; Saver, BG; Jackson, JE; Fishman, PA
Pharmacoepidemiology and Drug Safety, 14(): 877-884.
Continuation of hormone replacement therapy in Slovenia: A prospective, randomized, controlled trial - 1-year follow-up
Franic, D; Verdenik, I; Meden-Vrtovec, H; Svab, I
Maturitas, 54(2): 110-118.
Mayo Clinic Proceedings
Historical perspectives in postmenopausal hormone therapy: Defining the right dose and duration
Warren, MP
Mayo Clinic Proceedings, 82(2): 219-226.

New England Journal of Medicine
The decrease in breast-cancer incidence in 2003 in the United States
Ravdin, PM; Cronin, KA; Howlader, N; Berg, CD; Chlebowski, RT; Feuer, EJ; Edwards, BK; Berry, DA
New England Journal of Medicine, 356(): 1670-1674.

Breast Cancer Research and Treatment
Diffusion of aromatase inhibitors for breast cancer therapy between 1996 and 2003 in the Cancer Research Network
Aiello, EJ; Buist, DSM; Wagner, EH; Tuzzio, L; Greene, SM; Lamerato, LE; Field, TS; Herrinton, LJ; Haque, R; Hart, G; Bischoff, KJ; Geiger, AM
Breast Cancer Research and Treatment, 107(3): 397-403.
Journal of Womens Health
Prevalence and opinions of hormone therapy prior to the Women's Health Initiative: A multinational survey on four continents
Heinemann, K; Rubig, A; Strothmann, A; Nahum, GG; Heinemann, LAJ
Journal of Womens Health, 17(7): 1151-1166.
International Journal of Epidemiology
Hormone therapy and the rise and perhaps fall of US breast cancer incidence rates: critical reflections
Krieger, N
International Journal of Epidemiology, 37(3): 627-637.
Annals of Internal Medicine
Short-Term Hormone Therapy Suspension and Mammography Recall A Randomized Trial
Buist, DSM; Anderson, ML; Reed, SD; Bowles, EJA; Fitzgibbons, ED; Gandara, JC; Seger, D; Newton, KM
Annals of Internal Medicine, 150(): 752-W135.

Trends in middle-aged women's reports of symptoms, use of hormone therapy and attitudes towards it
Ekstrom, H
Maturitas, 52(2): 154-164.
Journal of General Internal Medicine
Average household exposure to newspaper coverage about the harmful effects of hormone therapy and population-based declines in hormone therapy use
Haas, JS; Miglioretti, DL; Geller, B; Buist, DSM; Nelson, DE; Kerlikowske, K; Carney, PA; Dash, S; Breslau, ES; Ballard-Barbash, R
Journal of General Internal Medicine, 22(1): 68-73.
Motives for initiation, temporary discontinuation, and permanent discontinuation of hormone replacement therapy use among Norwegian women
Oren, A
Maturitas, 64(1): 33-37.
Journal of Epidemiology and Community Health
Hormone replacement therapy, cancer, controversies, and women's health: historical, epidemiological, biological, clinical, and advocacy perspectives
Krieger, N; Lowy, I; Aronowitz, R; Bigby, J; Dickersin, K; Garner, E; Gaudilliere, JP; Hinestrosa, C; Hubbard, R; Johnson, PA; Missmer, SA; Norsigian, J; Pearson, C; Rosenberg, CE; Rosenberg, L; Rosenkrantz, BG; Seaman, B; Sonnenschein, C; Soto, AM; Thornton, J; Weisz, G
Journal of Epidemiology and Community Health, 59(9): 740-748.
Response to commentaries on retention of the ovaries and long-term survival after hysterectomy
Parker, WH; Broder, MS; Liu, Z; Shoupe, D; Farquhar, C; Berek, JS
Climacteric, 9(5): 396-398.
Menopause characteristics of women with physical disabilities from poliomyelitis
Kalpakjian, CZ; Quint, EH; Tate, DG; Roller, S; Toussaint, LL
Maturitas, 56(2): 161-172.
Medical Science Monitor
Women gynecologists' attitude toward their own health
Weissmann-Brenner, A; Brenner, B; Sulkes, J; Kaplan, B
Medical Science Monitor, 16(4): PH35-PH39.

Journal of Clinical Oncology
Low-dose tamoxifen for combination hormone replacement therapy users
Fabian, CJ
Journal of Clinical Oncology, 25(): 4162-4164.
Lancet Oncology
Survival patterns after oophorectomy in premenopausal women: a population-based cohort study
Rocca, WA; Grossardt, BR; de Andrade, M; D Malkasian, G; Melton, LJ
Lancet Oncology, 7(): 821-828.
Cancer Causes & Control
Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States)
Aiello, EJ; Buist, DSM; White, E
Cancer Causes & Control, 17(): 1227-1235.
Bmc Medical Research Methodology
Experiences of a long-term randomized controlled prevention trial in a maiden environment: Estonian Postmenopausal Hormone Therapy trial
Hovi, SL; Veerus, P; Rahu, M; Hemminki, E
Bmc Medical Research Methodology, 8(): -.
Journal of Womens Health
A review of drospirenone for safety and tolerability and effects on endometrial safety and lipid parameters contrasted with medroxyprogesterone acetate, levonorgestrel, and micronized progesterone
Shulman, LP
Journal of Womens Health, 15(5): 584-590.

Annual report to the nation on the status of cancer, 1975-2003, featuring cancer among US Hispanic/Latino populations
Howe, HL; Wu, XC; Ries, LAG; Cokkinides, V; Ahmed, F; Jemal, A; Miller, B; Williams, M; Ward, E; Wingo, PA; Ramirez, A; Edwards, BK
Cancer, 107(8): 1711-1742.
Journal of the National Cancer Institute
Declines in invasive breast cancer and use of postmenopausal hormone therapy in a screening mammography population
Kerlikowske, K; Miglioretti, DL; Buist, DSM; Walker, R; Carney, PA
Journal of the National Cancer Institute, 99(): 1335-1339.
Journal of Clinical Oncology
Predictors of tamoxifen discontinuation among older women with estrogen receptor-positive breast cancer
Owusu, C; Buist, DSM; Field, TS; Lash, TL; Thwin, SS; Geiger, AM; Quinn, VP; Frost, F; Prout, M; Yood, MU; Wei, F; Silliman, RA
Journal of Clinical Oncology, 26(4): 549-555.
American Journal of Surgery
The effects of hormone replacement therapy on postmenopausal breast cancer biology and survival
Sener, SF; Winchester, DJ; Winchester, DP; Du, HY; Barrera, E; Bilimoria, M; Krantz, S; Rabbitt, S
American Journal of Surgery, 197(3): 403-406.
Bmc Medicine
Recent trends in breast cancer incience in US white women by county-level urban/rural and poverty status
Hausauer, AK; Keegan, THM; Chang, ET; Glaser, SL; Howe, H; Clarke, CA
Bmc Medicine, 7(): -.
Adult weight gain and histopathologic characteristics of breast cancer among postmenopausal women
Feigelson, HS; Patel, AV; Teras, LR; Gansler, T; Thun, MJ; Calle, EE
Cancer, 107(1): 12-21.
Cancer Epidemiology Biomarkers & Prevention
Nonsteroidal anti-inflammatory drugs and change in mammographic density: A cohort study using pharmacy records on over 29,000 postmenopausal women
Terry, MB; Buist, DSM; Trentham-Dietz, A; James-Todd, TM; Liao, YY
Cancer Epidemiology Biomarkers & Prevention, 17(5): 1088-1095.
Cancer Causes & Control
The impact of changes in hormone therapy on breast cancer incidence in the US population
Coombs, NJ; Cronin, KA; Taylor, RJ; Freedman, AN; Boyages, J
Cancer Causes & Control, 21(1): 83-90.
Journal of General Internal Medicine
The impact of comorbidities on hormone use - After the 2002 release of the Women's Health Initiative
Newton, KM; Buist, DSM; Miglioretti, DL; Beverly, K; Hortsfield, CL; Chan, KA; Andrade, SE; Wei, FF; Connelly, M; Kessler, L
Journal of General Internal Medicine, 20(4): 350-356.
Journal of General Internal Medicine
How the women's health initiative (WHI) influenced physicians' practice and attitudes
Bush, TM; Bonomi, AE; Nekhlyudov, L; Ludman, EJ; Reed, SD; Connelly, MT; Grothaus, LC; LaCroix, AZ; Newton, KM
Journal of General Internal Medicine, 22(9): 1311-1316.
Increased risk of cognitive impairment or dementia in women who underwent oophorectomy before menopause
Rocca, WA; Bower, JH; Maraganore, DM; Ahlskog, JE; Grossardt, BR; de Andrade, M; Melton, LJ
Neurology, 69(): 1074-1083.

Cancer Epidemiology Biomarkers & Prevention
Relationship between menopausal hormone therapy and risk of ductal, lobular, and ductal-lobular breast carcinomas
Li, CI; Malone, KE; Porter, PL; Lawton, TJ; Voigt, LF; Cushing-Haugen, KL; Lin, MG; Yuan, XP; Daling, JR
Cancer Epidemiology Biomarkers & Prevention, 17(1): 43-50.
Current Oncology
Hormone replacement therapy and outcomes for women with non-small-cell lung cancer: can an association be confirmed?
Ayeni, O; Robinson, A
Current Oncology, 16(3): 162-166.

Beliefs about bioidentical hormone therapy: A cross-sectional survey of pharmacists
Siyam, T; Yuksel, N
Maturitas, 74(2): 196-202.
Breast Cancer Research and Treatment
Trends in breast cancer incidence and mortality in the United States: implications for prevention
Toriola, AT; Colditz, GA
Breast Cancer Research and Treatment, 138(3): 665-673.
Journal of Clinical Oncology
Ovarian Cancer Incidence Trends in Relation to Changing Patterns of Menopausal Hormone Therapy Use in the United States
Yang, HP; Anderson, WF; Rosenberg, PS; Trabert, B; Gierach, GL; Wentzensen, N; Cronin, KA; Sherman, ME
Journal of Clinical Oncology, 31(): 2146-U135.
Jama-Journal of the American Medical Association
The Women's Health Initiative-A Victory for Women and Their Health
Nabel, EG
Jama-Journal of the American Medical Association, 310(): 1349-1350.

Journal of Womens Health
Challenging and Complex Decisions in the Management of the BRCA Mutation Carrier
Stan, DL; Shuster, LT; Wick, MJ; Swanson, CL; Pruthi, S; Bakkum-Gamez, JN
Journal of Womens Health, 22(): 825-834.
Journal of Midwifery & Womens Health
The History of Hormone Therapy Use and Recent Controversy Related to Heart Disease and Breast Cancer Arising from Prevention Trial Outcomes
Alexander, IM
Journal of Midwifery & Womens Health, 57(6): 547-557.
Periodontology 2000
Endocrinology of menopause
Edwards, BJ; Li, J
Periodontology 2000, 61(): 177-194.
Clinical Obstetrics and Gynecology
Ovarian Conservation at the Time of Hysterectomy for Benign Disease
Clinical Obstetrics and Gynecology, 50(2): 354-361.
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Current Opinion in Obstetrics and Gynecology
Elective oophorectomy in the gynecological patient: when is it desirable?
Parker, WH; Shoupe, D; Broder, MS; Liu, Z; Farquhar, C; Berek, JS
Current Opinion in Obstetrics and Gynecology, 19(4): 350-354.
PDF (96) | CrossRef
Obstetrics & Gynecology
Ovarian Conservation at the Time of Hysterectomy for Benign Disease
Parker, WH; Broder, MS; Liu, Z; Shoupe, D; Farquhar, C; Berek, JS
Obstetrics & Gynecology, 106(2): 219-226.
PDF (266) | CrossRef
Medical Care
Impact of Hormone Therapy on False-Positive Recall and Costs Among Women Undergoing Screening Mammography
Boudreau, DM; Buist, DS; Rutter, CM; Fishman, PA; Beverly, KR; Taplin, S
Medical Care, 44(1): 62-69.

PDF (294)
The impact of the Women's Health Initiative Randomized Controlled Trial 2002 on perceived risk communication and use of postmenopausal hormone therapy in Germany
Heitmann, C; Greiser, E; Dören, M
Menopause, 12(4): 405-411.

PDF (70)
When is it appropriate to prescribe postmenopausal hormone therapy?
Ettinger, B; Barrett-Connor, E; Hoq, LA; Vader, J; Dubois, RW
Menopause, 13(3): 404-410.
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Decline in use of hormone therapy among postmenopausal women in the United Kingdom
Menon, U; Burnell, M; Sharma, A; Gentry-Maharaj, A; Fraser, L; Ryan, A; Parmar, M; Hunter, M; Jacobs, I; for the UKCTOCS Group,
Menopause, 14(3): 462-467.
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Perspective on menopausal vasomotor symptoms, CAM, and the SWAN
Pinkerton, JV; Pastore, LM
Menopause, 14(4): 601-605.
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Women's awareness and knowledge of hormone therapy post-Women's Health Initiative
Rigby, AJ; Ma, J; Stafford, RS
Menopause, 14(5): 853-858.
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Elective oophorectomy for benign gynecological disorders
Shoupe, D; Parker, WH; Broder, MS; Liu, Z; Farquhar, C; Berek, JS
Menopause, 14(3): 580-585.
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Trends of determinants of hormone therapy use in Italian women attending menopause clinics, 1997-2003
Parazzini, F; and the Progetto Menopausa Italia Study Group,
Menopause, 15(1): 164-170.
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Hormone therapy initiation after the Women's Health Initiative
Newton, KM; Buist, DS; Yu, O; Hartsfield, CL; Andrade, SE; Wei, F; Connelly, MT; Chan, K
Menopause, 15(3): 487-493.
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Increased cardiovascular mortality after early bilateral oophorectomy
Rivera, CM; Grossardt, BR; Rhodes, DJ; Brown, RD; Roger, VL; Melton, L; Rocca, WA
Menopause, 16(1): 15-23.
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The Acupuncture on Hot Flushes Among Menopausal Women (ACUFLASH) study, a randomized controlled trial
Borud, EK; Alraek, T; White, A; Fonnebo, V; Eggen, AE; Hammar, M; Åstrand, LL; Theodorsson, E; Grimsgaard, S
Menopause, 16(3): 484-493.
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Short-term (1-2 mo) hormone therapy cessation before mammography
Newton, KM; Reed, SD; Buist, DS; Anderson, ML; Aiello Bowles, EJ; Fitzgibbons, D; Seger, D
Menopause, 16(6): 1125-1131.
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