Obstetrics & Gynecology:
Posttraumatic Stress Disorder and Pregnancy Complications
SENG, JULIA S. CNM, PhD; OAKLEY, DEBORAH J. PhD; SAMPSELLE, CAROLYN M. RNC, PhD; KILLION, CHERYL RN, PhD; GRAHAM-BERMANN, SANDRA PhD; LIBERZON, ISRAEL MD
School of Nursing, Department of Psychology, and School of Medicine, The University of Michigan, Ann Arbor, Ann Arbor, Michigan.
Address reprint requests to: Julia S. Seng, CNM, PhD, University of Iowa, College of Nursing, Iowa City, IA 52242-1121. E-mail: email@example.com
Supported by Individual National Research Service Award NRO7301 from the National Institute of Nursing Research, Bethesda, Maryland; by a dissertation grant (315-SAP/98) from the Blue Cross and Blue Shield of Michigan Foundation, Detroit, Michigan; and by a Regents' Fellowship from the University of Michigan, Ann Arbor, Michigan (Dr. Seng). The data for this study were made available by Health Management Associates, Inc., Lansing, Michigan.
Received April 3, 2000. Received in revised form July 25, 2000. Accepted September 21, 2000.
Objective: To assess the associations between specific pregnancy complications and posttraumatic stress disorder based on neurobiologic and behavioral characteristics, using Michigan Medicaid claims data from 1994–1996.
Methods: Two thousand, two hundred nineteen female recipients of Michigan Medicaid who were of childbearing age had posttraumatic stress disorder on the basis of International Classification of Diseases, 9th Revision (ICD-9) codes. Twenty percent (n = 455) of those recipients and 30% of randomly selected comparison women with no mental health diagnostic codes (n = 638; P < .001) had ICD-9 diagnostic codes for pregnancy complications. We used multiple logistic regression to investigate associations between specific pregnancy complications and posttraumatic stress disorder, controlling for demographic and psychosocial variables. Obstetric complications were hypothesized based on high-risk behaviors and neurobiologic alterations in stress axis function in posttraumatic stress disorder.
Results: After controlling for demographic and psychosocial factors, women with posttraumatic stress disorder had higher odds ratios (ORs) for ectopic pregnancy (OR 1.7, 95% confidence interval [CI] 1.1, 2.8), spontaneous abortion (OR 1.9, 95% CI 1.3, 2.9), hyperemesis (OR 3.9, 95% CI 2.0, 7.4), preterm contractions (OR 1.4, 95% CI 1.1, 1.9), and excessive fetal growth (OR 1.5, 95% CI 1.0, 2.2). Hypothesized labor differences were not confirmed and no differences were found for complications not thought to be related to traumatic stress.
Conclusions: Pregnant women with posttraumatic stress disorder might be at higher risk for certain conditions, and assessment and treatment for undiagnosed posttraumatic stress might be warranted for women with those obstetric complications. Prospective studies are needed to confirm present findings and to determine potential biologic mechanisms. Treatment of traumatic stress symptoms might improve pregnancy morbidity and maternal mental health.
Violence against women is an important risk factor that affects public health. Effects of violence on women's health might be mediated by biologic and psychosocial sequelae in the form of traumatic stress-related disorders. Large epidemiologic studies using random samples of nonclinical populations showed that the prevalence of lifetime posttraumatic stress disorder1 among women of all ages was between 10.4% and 12.3%, with rates of 25–50% among women exposed to abuse or assault trauma.2–4 An analysis of lifespan exposures to trauma5 found that rates of exposure to traumas, including assaults, peak between 16 and 20 years of age and decrease precipitously thereafter, suggesting that exposure and posttraumatic stress disorder occurred early enough in life to precede childbearing in many women.6,7
We hypothesized that posttraumatic stress disorder could affect childbearing by behavioral alterations8,9 (eg, disordered eating, high-risk sexuality, substance use) and neuroendocrine alterations10,11 (cortisol, vasopressin, and oxytocin) that are associated with posttraumatic stress disorder in women. We hypothesized that the following obstetric complications would be more frequent among women with posttraumatic stress disorder: problems with fertility, elective and spontaneous abortion, nausea, vomiting and hyperemesis, preterm contractions, postdate gestation, excessive fetal growth (caused by excessive maternal weight gain), dysfunctional labor contractions, failed lactation, postpartum mood disorders, and altered attachment. Low birth weight (LBW) and preterm birth have been associated with violence between intimate partners during pregnancy, an acute life event stress that might be superimposed on posttraumatic stress disorder.12 Each of those complications has a behavioral risk factor, a hormonal risk factor related to oxytocin-vasopressin dysregulation, or both (eg, ectopic pregnancy caused by prior infection and dysregulated smooth muscle function in the fallopian tube). The hypothesized complications were consistent with problems identified in the clinical literature about pregnant sexually abused women, a population with a high prevalence of posttraumatic stress disorder.8 We did not expect that women with posttraumatic stress disorder would have other obstetric complications, such as preeclampsia or gestational diabetes, because we did not see any posttraumatic stress disorder–related mechanism to increase their incidence, although we included them in the analysis as alternative explanations for fetal weight problems, labor induction, and cesarean delivery. Hypotheses about some of the specified complications (infertility, elective abortion, lactation problems, and postpartum mood and attachment disorders) could not be tested because of lack of codes for those conditions in the Medicaid database we used. Therefore, the aim of this preliminary analysis was to test the hypothesis that the following complications were associated with a posttraumatic stress disorder diagnosis: spontaneous abortion, ectopic pregnancy, sexually transmitted disease in pregnancy, hyperemesis, preterm contractions, concerns about fetal weight (inadequate or excessive), postdate gestation with and without oxytocin induction, and dysfunctional labor contractions (precipitous or hypotonic leading to oxytocin augmentation, cesarean birth, or postpartum hemorrhage).
Materials and Methods
We used a dataset with mental health and perinatal data, Michigan's Medicaid Eligibility and Paid Claims records, to test our hypothesis. The data included the completely processed fee-for-service records beginning January 1, 1994 and ending December 31, 1996 for 526,692 women born from 1950–1983. The data had been encrypted to protect confidentiality, and The University of Michigan institutional review board approved this secondary analysis. Variables for this analysis came from International Classification of Diseases, 9th Revision (ICD-9)13 diagnostic codes from hospital episodes and some procedure coding gathered by standardized billing forms and hospital chart reviews. Age, ethnicity, and program code variables came from eligibility information. Those data were converted from the multitable relational database to single-spreadsheet variables for analysis using SPSS version 7.5 (SPSS, Inc., Chicago, IL).
Cases of posttraumatic stress disorder were identified by presence of the ICD-9 diagnostic code 309.81. The American Psychiatric Association1 diagnostic criteria for this code require (A) presence of a qualifying trauma, and (B) one symptom of intrusive reexperiencing, (C) three symptoms of avoidance and numbing, and (D) two symptoms of arousal, with symptom duration longer than 1 month and significant functional impairment. Female recipients of Medicaid who had inpatient or outpatient ICD-9 code 309.81 were selected (n = 2219). An equal number of records were extracted by random-case selection process among female recipients who had no psychiatric diagnostic codes to form a comparison group. Among the 4438 women, 1093 had at least one diagnostic code relating to pregnancy (ICD-9 codes 630–676) and no code for multiple gestation because many of the hypothesized complications are associated with multiple gestation. Diagnostic bivariate and regression tests to assess the effect of including censored data showed no significant differences between groups.14 Given the cross-sectional nature of this preliminary study, in which no longitudinal analyses were planned, data from those cases were retained. Thus, the analysis included 455 women (41.6%) in the posttraumatic stress disorder group and 638 women (58.4%) in the comparison group.
Three categories of variables were developed. Demographic variables included ethnicity, age, and program code (ie, reason for eligibility) in effect at the last pregnancy-related service. Bivariate analysis showed that being eligible for Medicaid because of disability correlated strongly with posttraumatic stress disorder diagnosis (Table 1). We eliminated the disability demographic variable because it violated the noncorrelated independent variables assumption of regression analysis.15 From those data we could not tell whether the disabled women had posttraumatic stress disorder subsequent to a disabling injury or illness or whether the psychiatric disorder was the cause of disability. If the latter was true, those cases represent a level of severity of posttraumatic stress that might affect generalizability. Psychosocial screening variables included drug dependence complicating pregnancy (code 648.3), mental disorder complicating pregnancy (code 648.4), and a proxy variable for abuse and assault combining v-codes for emergency room observations after rape (code v71.5) or inflicted injury (code v71.6), and current domestic violence and counseling visits relating to abuse (codes v61.11 and v61.21). Obstetric variables show that diagnosis did or did not occur in the record.
Bivariate comparisons are presented for descriptive purposes. Comparisons that were significant after Bonferroni correction for multiple comparisons16 are indicated. Given the exploratory nature of this analysis, focusing on variables that are significant by the stringent Bonferroni criterion (P < .002) would likely result in a type II error. Therefore, all potential variables were included in the initial regression analysis.
The logistic regression model constructed for this analysis estimated association of multiple demographic, psychosocial, and obstetric variables with the single, dichotomous grouping variable (diagnosed with posttraumatic stress disorder or not). That model (Table 2) resulted from backward elimination of nonsignificant obstetric variables from among conditions we hypothesized were associated with posttraumatic stress disorder and any potentially confounding factors, such as preeclampsia accounting for induction and gestational diabetes accounting for excessive fetal weight. The variables were entered in a forward stepwise progression15 so that differences between groups on the basis of obstetric conditions have already taken into account the women's demographic and psychosocial factors. Model efficacy was evaluated using lambda-p15 (cases incorrectly predicted subtracted from cases correctly predicted and divided by cases correctly predicted) to determine the proportion reduction in error of prediction from using this model compared with chance.
Among 526,629 female Medicaid recipients with fee-for-service data from 1994–1996, 104,287 (19.8%) had at least one mental health diagnostic code from among the ICD-9 codes 290–347. Among those women, 2219 (2.1%) had code 309.81 for posttraumatic stress disorder. That is a prevalence of 0.4%, which likely represents an underreporting of the disorder.2
Bivariate tests on demographic variables (Table 1) showed no group differences in age. There were more white women in the diagnosed group, although it cannot be ascertained from the data if that was caused by differences in exposure to trauma, vulnerability, or likelihood of clinician assigning the posttraumatic stress disorder diagnosis. In the posttraumatic stress disorder group, 18.9% of women were in a disability program, versus 1.6% in the comparison group. Among women with posttraumatic stress disorder diagnoses, 17.4% had hospital episodes in which posttraumatic stress disorder was the primary diagnosis, and 22% of them also had substance abuse diagnoses.
Groups differed significantly on all psychosocial proxies. Emergency room observations after alleged rape and inflicted injury, or counseling visits related to abuse had been recorded for 6.4% of the posttraumatic stress disorder group and 0.8% of the comparison group. Half of the 29 women with victim service codes had prior posttraumatic stress disorder codes. Maternity care providers noted that pregnancy was complicated by drug dependence (1.3% overall) or mental disorder (2.8% overall) more often among women in the posttraumatic stress disorder group, but relatively infrequently given the proportion of women in the analysis who had mental health diagnoses for posttraumatic stress disorder (41.6%) and substance abuse (22%) during the 3-year period.
In bivariate testing of the pregnancy variables (Table 3), diagnostic codes for hospital episodes of spontaneous abortion or excessive vomiting were significantly associated with posttraumatic stress disorder diagnosis and remained significant after Bonferroni correction (set at P < .002). At a marginal level of significance, ectopic pregnancy, preterm contractions, excessive fetal growth, and poor fetal growth all were more frequent in the posttraumatic stress disorder group. Pregnancy problems that were hypothesized to be unrelated to posttraumatic stress disorder, including gestational diabetes and preeclampsia, did not occur at significantly different rates between groups. There were no significant bivariate differences between groups for some conditions that were hypothesized to be related to oxytocin dysregulation, including postdate gestation and dysfunctional labor diagnostic and treatment codes, such as uterine inertia or cesarean delivery.
The logistic regression model (Table 2) found five of the hypothesized complications to be significantly associated with posttraumatic stress disorder, after controlling for demographic and psychosocial factors. Women who had excessive vomiting were most likely to have been diagnosed with posttraumatic stress disorder. Those who had ectopic pregnancies, hospital treatment for miscarriage, a code that indicated concern about macrosomia, or had hospital episodes for preterm contractions and eventually gave birth at term were also more likely to have been diagnosed with posttraumatic stress disorder.
Assessment of the final regression model's efficacy by lambda-p15 showed 11% improvement over chance when using the demographic and psychosocial screening variables alone to predict which group each case belonged in. When obstetric variables were added, proportional reduction in error of prediction improved to 19%.
Our findings suggest that women with posttraumatic stress disorder might be at higher risk for some physical pregnancy problems, which were predicted based on known behavioral and neuroendocrine sequelae of traumatic stress, including ectopic pregnancy, spontaneous abortion, hyperemesis, preterm contractions, and excessive fetal growth. Hypothesized labor differences were not confirmed in those data. No differences were found in complication rates that were not believed to be related to traumatic stress, such as preeclampsia or gestational diabetes.
A number of limitations of our study exist. First, results of this study cannot be generalized to insured women, although they might be relevant to the United States Medicaid population.17 Second, these existing service usage data appear to underreport posttraumatic stress disorder, which might cause underestimation of associations studied because undiagnosed women with posttraumatic stress disorder were included in the comparison group. It is also possible that only the most severely affected women were diagnosed. Third, service usage data provide no information about antecedent trauma. Women with such trauma exposures as car accidents or house fires might be less likely to be triggered by and become symptomatic during pregnancy, making it less likely that their childbearing would be disrupted by posttraumatic stress. Fourth, women with the posttraumatic stress disorder diagnostic code likely receive some treatment for the disorder that might decrease its effect on their pregnancies. Epidemiologic data suggest that it is likely that most disorder-diagnosed women were first exposed to abuse and affected by traumatic stress symptoms before pregnancy.3–7 However, given the 3-year time limit of those data, it is impossible to determine chronology with certainty. It is also possible that posttraumatic stress disorder developed in women subsequent to pregnancy. Generally, that source of error would introduce a conservative bias by diluting differences between groups because the disorder acquired after pregnancy could not logically cause complications. However, a condition such as ectopic pregnancy could be life-threatening and thus be a traumatic stressor causing a new incidence of the disorder. Post hoc determination of dates for posttraumatic stress disorder codes and ectopic pregnancy codes was done for the 45 women in the posttraumatic stress disorder group who had ectopic pregnancies. The posttraumatic stress disorder code predated the ectopic code for 32 women (71%). Posttraumatic stress disorder is a chronic recurrent condition,18 so it is likely that few, if any, of the remaining cases had new onset after ectopic pregnancy diagnoses, and thus are unlikely to significantly affect results. The question of whether traumatic stress results from some obstetric experiences is a separate question that also warrants study.
This preliminary study from existing data expands current thinking about the effect of stress in pregnancy by considering traumatic stress rather than life-event stressors, daily stress, or anxiety.19 It also differs from prior studies by considering specifically the complications that could be mediated by behavioral and neuroendocrine mechanisms among women with posttraumatic stress disorder, particularly those mediated by oxytocin.
Future research is needed to corroborate and extend our findings, examine causality, study biologic mechanisms, and identify posttraumatic stress disorder–related interventions. Prospective studies should measure trauma exposure and posttraumatic stress disorder with instruments validated for use with women.20,21 Posttraumatic stress disorder and childbearing are both complex phenomena with many likely mediating or moderating factors, such as current battering, socioeconomic stressors, life events, social support, and comorbid obstetric, medical, and psychiatric conditions. Additional moderators such as women's coping strategies, prior or current mental health care, and client-provider alliance in maternity care should also be considered.
The preliminary data presented here point toward potentially important clinical implications. Should women's health care providers screen for posttraumatic stress symptoms and the associated problems with eating, substance abuse, and high-risk sex, especially among women with histories of abuse or assault? There are treatments available for posttraumatic stress disorder.22 Treatment early enough to precede conception might lead to prevention of some risk behaviors and some childbearing morbidity. For gravidas with ideopathic hyperemesis or preterm contractions, posttraumatic stress disorder could be an additional differential diagnosis. Psychopharmacologic and psychologic interventions for posttraumatic stress might bring quick relief. For those women, an oxytocin antagonist might be the more effective tocolytic. Last but not least, getting mental health treatment for the mother before birth also might improve the well-being of her infant.
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