BACKGROUND: Multiminicore disease is a congenital myopathy characterized by muscle weakness and respiratory impairment. Predilection for the development of malignant hyperthermia has been reported in select patients. Little is known about pregnancy outcomes, although patients with other neuromuscular disorders may experience a postpartum decline.
CASE: We report a case of pregnancy associated with autosomal-recessive multiminicore disease. Genetic implications of this condition were addressed. Orthopedic complications were managed through physical medicine and rehabilitation consultation. Under epidural anesthesia, a healthy full-term neonate was delivered through spontaneous vaginal delivery. There was no evidence of malignant hyperthermia or functional decline in the puerperium.
CONCLUSION: A successful pregnancy outcome was achieved in a patient with multiminicore myopathy by proactively addressing potential genetic, orthopedic, and anesthetic concerns associated with this condition.
Treatment of obstetric patients who have autosomal-recessive multiminicore myopathy should address genetic, anesthetic, and orthopedic concerns to prevent complications and progression of the disease.
Wayne State University School of Medicine and the Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan.
Corresponding author: Bernard Gonik, MD, 6071 West Outer Drive, Suite M541, Detroit, MI 48235; e-mail: firstname.lastname@example.org.
Financial Disclosure The authors did not report any potential conflicts of interest.